SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ixq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WG8_B_SAMB3141_0 (PREDICTED S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE)	2ixq	PROTEIN AFAD (Escherichia coli)	5 / 12	PRO A 86 GLY A 68 GLY A 69 GLY A 71 GLN A 44	PRO A 86 ( 1.0A) GLY A 68 ( 0.0A) GLY A 69 ( 0.0A) GLY A 71 ( 0.0A) GLN A 44 ( 0.6A)	1.04A	1wg8B-2ixqA: undetectable	1wg8B-2ixqA: 18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y05_A_RALA802_1 (PROSTAGLANDIN REDUCTASE 1)	2ixq	PROTEIN AFAD (Escherichia coli)	4 / 7	VAL A 113 GLY A 68 VAL A 65 ASP A 70	VAL A 113 ( 0.5A) GLY A 68 ( 0.0A) VAL A 65 ( 0.5A) ASP A 70 ( 0.4A)	0.85A	2y05A-2ixqA: undetectable 2y05B-2ixqA: undetectable	2y05A-2ixqA: 17.59 2y05B-2ixqA: 17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZBR_A_ACTA608_0 (SERUM ALBUMIN)	2ixq	PROTEIN AFAD (Escherichia coli)	3 / 3	LYS A 57 ARG A 60 HIS A 61	LYS A 57 ( 0.0A) ARG A 60 ( 0.6A) HIS A 61 ( 1.0A)	1.06A	4zbrA-2ixqA: undetectable	4zbrA-2ixqA: 12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TUD_D_ERMD1201_2 (5-HYDROXYTRYPTAMINE RECEPTOR 2B,SOLUBLE CYTOCHROME B562 CHIMERA)	2ixq	PROTEIN AFAD (Escherichia coli)	4 / 6	LEU A 16 THR A 142 LEU A 6 GLU A 42	LEU A 16 ( 0.4A) THR A 142 ( 0.2A) LEU A 6 ( 0.5A) GLU A 42 ( 0.5A)	0.96A	5tudD-2ixqA: undetectable	5tudD-2ixqA: 14.42

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1WG8_B_SAMB3141_0","PREDICTED S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","2ixq","PROTEIN AFAD","Escherichia coli",5,"PRO A  86;GLY A  68;GLY A  69;GLY A  71;GLN A  44","PRO A  86 ( 1.0A);GLY A  68 ( 0.0A);GLY A  69 ( 0.0A);GLY A  71 ( 0.0A);GLN A  44 ( 0.6A)","1.04A","1wg8B-2ixqA:undetectable","1wg8B-2ixqA:18.60"],["2Y05_A_RALA802_1","PROSTAGLANDIN REDUCTASE 1;PROSTAGLANDIN REDUCTASE 1","2ixq","PROTEIN AFAD","Escherichia coli",4,"VAL A 113;GLY A  68;VAL A  65;ASP A  70","VAL A 113 ( 0.5A);GLY A  68 ( 0.0A);VAL A  65 ( 0.5A);ASP A  70 ( 0.4A)","0.85A","2y05A-2ixqA:undetectable;2y05B-2ixqA:undetectable","2y05A-2ixqA:17.59;2y05B-2ixqA:17.59"],["4ZBR_A_ACTA608_0","SERUM ALBUMIN","2ixq","PROTEIN AFAD","Escherichia coli",3,"LYS A  57;ARG A  60;HIS A  61","LYS A  57 ( 0.0A);ARG A  60 ( 0.6A);HIS A  61 ( 1.0A)","1.06A","4zbrA-2ixqA:undetectable","4zbrA-2ixqA:12.52"],["5TUD_D_ERMD1201_2","5-HYDROXYTRYPTAMINE RECEPTOR 2B,SOLUBLE CYTOCHROME B562 CHIMERA","2ixq","PROTEIN AFAD","Escherichia coli",4,"LEU A  16;THR A 142;LEU A   6;GLU A  42","LEU A  16 ( 0.4A);THR A 142 ( 0.2A);LEU A   6 ( 0.5A);GLU A  42 ( 0.5A)","0.96A","5tudD-2ixqA:undetectable","5tudD-2ixqA:14.42"]]