SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ixs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2ixs SDAI RESTRICTION
ENDONUCLEASE
(Streptomyces
diastaticus) 		4 / 7 ALA A 249
LEU A 234
VAL A 186
MET A 185
 None
 0.89A 1hk2A-2ixsA:
undetectable		 1hk2A-2ixsA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 2ixs SDAI RESTRICTION
ENDONUCLEASE
(Streptomyces
diastaticus) 		5 / 9 GLY A 274
ALA A 273
THR A 270
LEU A 223
PHE A 268
 None
 1.10A 1nr6A-2ixsA:
undetectable		 1nr6A-2ixsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2ixs SDAI RESTRICTION
ENDONUCLEASE
(Streptomyces
diastaticus) 		4 / 7 ALA A 273
PRO A 271
LEU A 275
LEU A 244
 None
 1.00A 4iomA-2ixsA:
undetectable		 4iomA-2ixsA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2ixs SDAI RESTRICTION
ENDONUCLEASE
(Streptomyces
diastaticus) 		4 / 8 ALA A 273
PRO A 271
LEU A 275
LEU A 244
 None
 0.95A 4jjkA-2ixsA:
undetectable		 4jjkA-2ixsA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 2ixs SDAI RESTRICTION
ENDONUCLEASE
(Streptomyces
diastaticus) 		4 / 7 SER A 128
TYR A 129
ARG A 157
PHE A  24
 None
EPE  A1329 (-4.6A)
EPE  A1329 ( 4.7A)
None
 1.29A 4xzkA-2ixsA:
undetectable		 4xzkA-2ixsA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 2ixs SDAI RESTRICTION
ENDONUCLEASE
(Streptomyces
diastaticus) 		5 / 12 THR A  88
THR A  38
LEU A  42
GLY A  96
ALA A 122
 None
 1.05A 4ypmA-2ixsA:
undetectable		 4ypmA-2ixsA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2ixs SDAI RESTRICTION
ENDONUCLEASE
(Streptomyces
diastaticus) 		4 / 6 ALA A  17
GLY A  44
ILE A  64
PHE A  84
 None
 0.89A 6f8cA-2ixsA:
undetectable		 6f8cA-2ixsA:
14.24