SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iy0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2iy0 RAN
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 5 PHE C 473
PHE C 512
PHE C 507
VAL C 494
 None
 1.26A 2lh6A-2iy0C:
undetectable		 2lh6A-2iy0C:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2iy0 RAN
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASP C 495
THR C 463
THR C 461
ALA C 472
TYR C 550
 None
 1.38A 4dajB-2iy0C:
undetectable		 4dajB-2iy0C:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2iy0 RAN
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASP C 495
THR C 463
THR C 461
ALA C 472
TYR C 550
 None
 1.29A 4u15A-2iy0C:
undetectable		 4u15A-2iy0C:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2iy0 RAN
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASP C 495
THR C 463
THR C 461
ALA C 472
TYR C 550
 None
 1.26A 5dsgA-2iy0C:
undetectable		 5dsgA-2iy0C:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 2iy0 RAN
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 6 SER C 477
ALA C 472
THR C 461
ALA C 496
 None
 1.04A 6ma6A-2iy0C:
undetectable		 6ma6A-2iy0C:
16.77