SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iy4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2iy4 NON-HEME
IRON-CONTAINING
FERRITIN
(Listeria
monocytogenes) 		3 / 3 LEU A 119
PHE A  12
ARG A 110
 None
 0.73A 1xdkB-2iy4A:
undetectable		 1xdkB-2iy4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2iy4 NON-HEME
IRON-CONTAINING
FERRITIN
(Listeria
monocytogenes) 		3 / 3 LEU A 119
PHE A  12
ARG A 110
 None
 0.73A 1xdkF-2iy4A:
undetectable		 1xdkF-2iy4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2iy4 NON-HEME
IRON-CONTAINING
FERRITIN
(Listeria
monocytogenes) 		4 / 7 LEU A 106
LEU A 102
PHE A  23
GLU A  52
 None
 0.90A 2vq5B-2iy4A:
undetectable		 2vq5B-2iy4A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2iy4 NON-HEME
IRON-CONTAINING
FERRITIN
(Listeria
monocytogenes) 		4 / 8 LEU A 102
ILE A 139
TYR A 113
GLN A  56
 None
 0.90A 2weyB-2iy4A:
2.4		 2weyB-2iy4A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 2iy4 NON-HEME
IRON-CONTAINING
FERRITIN
(Listeria
monocytogenes) 		5 / 12 MET A  46
ILE A  27
LYS A  93
MET A  95
VAL A  84
 None
 1.05A 3a51C-2iy4A:
undetectable		 3a51C-2iy4A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 2iy4 NON-HEME
IRON-CONTAINING
FERRITIN
(Listeria
monocytogenes) 		5 / 12 MET A  46
ILE A  27
LYS A  93
MET A  95
VAL A  84
 None
 0.88A 3a51D-2iy4A:
undetectable		 3a51D-2iy4A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 2iy4 NON-HEME
IRON-CONTAINING
FERRITIN
(Listeria
monocytogenes) 		5 / 12 MET A  46
ILE A  27
LYS A  93
MET A  95
VAL A  84
 None
 1.04A 3a51E-2iy4A:
2.4		 3a51E-2iy4A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2iy4 NON-HEME
IRON-CONTAINING
FERRITIN
(Listeria
monocytogenes) 		5 / 12 ASP A  58
GLU A  59
LEU A  65
MET A 131
PHE A 135
 None
 1.31A 4pfjB-2iy4A:
undetectable		 4pfjB-2iy4A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2iy4 NON-HEME
IRON-CONTAINING
FERRITIN
(Listeria
monocytogenes) 		5 / 12 ASP A  58
GLU A  59
LEU A  65
MET A 131
PHE A 135
 None
 1.28A 4pgfB-2iy4A:
undetectable		 4pgfB-2iy4A:
15.73