SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iy9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 2iy9 SUBA
(Escherichia
coli) 		4 / 6 VAL A 106
VAL A 218
ILE A 146
ASN A 148
 None
 0.92A 1e06A-2iy9A:
undetectable		 1e06A-2iy9A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2iy9 SUBA
(Escherichia
coli) 		4 / 8 SER A  49
ILE A 149
GLY A 151
GLY A  54
 None
 0.70A 1me7A-2iy9A:
undetectable		 1me7A-2iy9A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2iy9 SUBA
(Escherichia
coli) 		5 / 10 SER A  49
ASN A 148
ILE A 149
GLY A 151
GLY A  54
 None
 1.13A 1mehA-2iy9A:
undetectable		 1mehA-2iy9A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 2iy9 SUBA
(Escherichia
coli) 		5 / 12 PRO A 230
GLY A 253
SER A 269
ALA A 250
ALA A 219
 None
 1.31A 1nw5A-2iy9A:
undetectable		 1nw5A-2iy9A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1U_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 2iy9 SUBA
(Escherichia
coli) 		5 / 10 ILE A  30
VAL A 106
VAL A 278
GLY A 280
TRP A  25
 None
 1.25A 1s1uA-2iy9A:
1.5		 1s1uA-2iy9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2iy9 SUBA
(Escherichia
coli) 		5 / 12 ALA A 251
ILE A 249
ILE A 277
VAL A 281
ILE A 146
 None
 1.10A 1xozA-2iy9A:
undetectable		 1xozA-2iy9A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 2iy9 SUBA
(Escherichia
coli) 		5 / 12 GLN A 153
ASP A  52
GLY A  90
SER A 272
ALA A  85
 None
 1.25A 3d91A-2iy9A:
undetectable		 3d91A-2iy9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 2iy9 SUBA
(Escherichia
coli) 		5 / 12 GLY A  90
SER A 114
SER A 272
GLY A 151
SER A 150
 None
 1.02A 3g2oA-2iy9A:
2.5		 3g2oA-2iy9A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2iy9 SUBA
(Escherichia
coli) 		4 / 5 SER A 240
ARG A 319
GLY A 318
GLU A 317
 None
 1.31A 3k9fA-2iy9A:
undetectable
3k9fB-2iy9A:
undetectable
3k9fC-2iy9A:
undetectable		 3k9fA-2iy9A:
23.53
3k9fB-2iy9A:
23.53
3k9fC-2iy9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2iy9 SUBA
(Escherichia
coli) 		5 / 12 HIS A  89
LEU A  96
LEU A  61
SER A 272
GLY A 266
 None
 1.00A 3kk6B-2iy9A:
0.0		 3kk6B-2iy9A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 2iy9 SUBA
(Escherichia
coli) 		4 / 8 PRO A  79
SER A  53
GLY A  54
PRO A 261
 None
 0.87A 3lslA-2iy9A:
undetectable
3lslD-2iy9A:
1.4		 3lslA-2iy9A:
23.55
3lslD-2iy9A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2iy9 SUBA
(Escherichia
coli) 		5 / 10 VAL A 320
ALA A 326
VAL A 281
ILE A  30
ILE A 249
 None
 1.38A 3retA-2iy9A:
undetectable
3retB-2iy9A:
undetectable		 3retA-2iy9A:
14.20
3retB-2iy9A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 2iy9 SUBA
(Escherichia
coli) 		3 / 3 PHE A  78
LYS A  68
SER A 114
 None
 1.32A 3tyeB-2iy9A:
undetectable		 3tyeB-2iy9A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2iy9 SUBA
(Escherichia
coli) 		5 / 11 GLY A 239
ASP A 184
ALA A 186
GLY A 185
VAL A 181
 None
 1.40A 4c5lA-2iy9A:
4.1		 4c5lA-2iy9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2iy9 SUBA
(Escherichia
coli) 		5 / 9 GLY A 239
ASP A 184
ALA A 186
GLY A 185
VAL A 181
 None
 1.39A 4c5lB-2iy9A:
3.0		 4c5lB-2iy9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2iy9 SUBA
(Escherichia
coli) 		5 / 10 GLY A 239
ASP A 184
ALA A 186
GLY A 185
VAL A 181
 None
 1.39A 4c5lC-2iy9A:
3.6		 4c5lC-2iy9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2iy9 SUBA
(Escherichia
coli) 		5 / 10 GLY A 239
ASP A 184
ALA A 186
GLY A 185
VAL A 181
 None
 1.41A 4c5lD-2iy9A:
4.1		 4c5lD-2iy9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2iy9 SUBA
(Escherichia
coli) 		5 / 10 GLY A 239
ASP A 184
ALA A 186
GLY A 185
VAL A 181
 None
 1.37A 4c5nD-2iy9A:
4.0		 4c5nD-2iy9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2iy9 SUBA
(Escherichia
coli) 		5 / 11 ASP A 248
ALA A 250
VAL A 278
ILE A 177
ASP A 213
 None
 1.10A 4uuuA-2iy9A:
undetectable
4uuuB-2iy9A:
undetectable		 4uuuA-2iy9A:
17.10
4uuuB-2iy9A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2iy9 SUBA
(Escherichia
coli) 		4 / 6 ALA A 274
THR A 275
VAL A 278
VAL A 247
 None
 0.83A 5eclA-2iy9A:
undetectable		 5eclA-2iy9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2iy9 SUBA
(Escherichia
coli) 		4 / 6 ALA A 274
THR A 275
VAL A 278
VAL A 247
 None
 0.69A 5eclD-2iy9A:
undetectable		 5eclD-2iy9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2iy9 SUBA
(Escherichia
coli) 		5 / 10 PRO A 261
LEU A  61
ALA A 110
VAL A  50
PRO A  79
 None
 1.25A 5m0oA-2iy9A:
undetectable		 5m0oA-2iy9A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2iy9 SUBA
(Escherichia
coli) 		5 / 12 VAL A 320
ASP A 306
ALA A 251
GLY A  31
LEU A  32
 None
 1.20A 5m54E-2iy9A:
2.5		 5m54E-2iy9A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2iy9 SUBA
(Escherichia
coli) 		5 / 12 VAL A 320
ASP A 306
ALA A 251
GLY A  31
LEU A  32
 None
 1.10A 5m5cB-2iy9A:
2.4		 5m5cB-2iy9A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2iy9 SUBA
(Escherichia
coli) 		5 / 10 VAL A 320
ASP A 306
ALA A 251
GLY A  31
LEU A  32
 None
 1.11A 5m5cE-2iy9A:
2.6		 5m5cE-2iy9A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2iy9 SUBA
(Escherichia
coli) 		3 / 3 MET A 169
GLU A 144
ARG A 175
 None
 1.07A 5tjyA-2iy9A:
2.9		 5tjyA-2iy9A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2iy9 SUBA
(Escherichia
coli) 		3 / 3 MET A 169
GLU A 144
ARG A 175
 None
 1.12A 5tjzA-2iy9A:
2.9		 5tjzA-2iy9A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2iy9 SUBA
(Escherichia
coli) 		5 / 12 ASP A 184
ALA A 220
GLY A 182
VAL A 218
TRP A 246
 None
 1.26A 6clxA-2iy9A:
undetectable		 6clxA-2iy9A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2iy9 SUBA
(Escherichia
coli) 		4 / 8 GLY A 318
LEU A 311
VAL A 247
LEU A 221
 None
 0.74A 6czmD-2iy9A:
undetectable
6czmF-2iy9A:
undetectable		 6czmD-2iy9A:
23.28
6czmF-2iy9A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2iy9 SUBA
(Escherichia
coli) 		5 / 11 VAL A 218
ALA A 274
LEU A 301
ALA A 251
LEU A 221
 None
 1.32A 6dk1B-2iy9A:
undetectable		 6dk1B-2iy9A:
19.72