SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iya'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 7 LEU A  36
ALA A 409
THR A 238
VAL A 235
 None
 0.97A 1dvxB-2iyaA:
undetectable		 1dvxB-2iyaA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 11 PHE A  18
LEU A 101
ALA A 104
VAL A  97
HIS A  14
 None
 1.30A 1qabE-2iyaA:
0.0		 1qabE-2iyaA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 7 PHE A 187
LEU A 190
LEU A 194
GLU A 147
 None
 0.95A 2jn3A-2iyaA:
undetectable		 2jn3A-2iyaA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 SER A 333
HIS A 368
ASP A 372
 UDP  A1424 (-2.7A)
None
None
 0.72A 2oxtA-2iyaA:
2.4		 2oxtA-2iyaA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 5 SER A 333
GLY A 263
HIS A 368
ASP A 372
 UDP  A1424 (-2.7A)
UDP  A1424 ( 3.9A)
None
None
 1.11A 2oxtB-2iyaA:
2.5		 2oxtB-2iyaA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 TRP A 312
GLN A 311
TRP A  79
 UDP  A1424 (-3.6A)
None
ZIO  A1425 (-3.8A)
 1.28A 2vqyA-2iyaA:
undetectable		 2vqyA-2iyaA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 12 ILE A 360
LEU A 365
LEU A 396
THR A 139
THR A 334
 None
None
None
ZIO  A1425 (-3.7A)
None
 1.17A 3dcjA-2iyaA:
6.1
3dcjB-2iyaA:
6.8		 3dcjA-2iyaA:
23.66
3dcjB-2iyaA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 GLU A 352
SER A 137
VAL A 215
 ZIO  A1425 (-3.8A)
None
None
 0.84A 3eeoA-2iyaA:
5.3		 3eeoA-2iyaA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 7 GLY A 407
GLY A 236
THR A 233
ALA A 411
 None
 0.81A 3fpjB-2iyaA:
4.7		 3fpjB-2iyaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 ASP A 317
LEU A 316
GLN A  34
 None
 0.63A 3g4lA-2iyaA:
undetectable		 3g4lA-2iyaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 10 ALA A 413
GLY A 418
ILE A 419
VAL A  43
LEU A  36
 None
 0.83A 3ogpA-2iyaA:
undetectable		 3ogpA-2iyaA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 7 LEU A  36
ALA A 409
THR A 238
VAL A 235
 None
 1.01A 3ozkB-2iyaA:
undetectable		 3ozkB-2iyaA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 LEU A 259
ARG A 293
ASN A  27
 None
None
UDP  A1424 (-4.0A)
 0.71A 3qxvD-2iyaA:
undetectable		 3qxvD-2iyaA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 11 ILE A 214
VAL A 114
VAL A 134
HIS A  41
ILE A  15
 None
 1.24A 3rf4A-2iyaA:
undetectable
3rf4C-2iyaA:
undetectable		 3rf4A-2iyaA:
13.79
3rf4C-2iyaA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 11 HIS A  41
ILE A  15
ILE A 214
VAL A 114
VAL A 134
 None
 1.25A 3rf4A-2iyaA:
undetectable
3rf4B-2iyaA:
undetectable		 3rf4A-2iyaA:
13.79
3rf4B-2iyaA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 11 HIS A  41
ILE A  15
ILE A 214
VAL A 114
VAL A 134
 None
 1.20A 3rf4B-2iyaA:
undetectable
3rf4C-2iyaA:
undetectable		 3rf4B-2iyaA:
13.79
3rf4C-2iyaA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 8 GLN A 315
PHE A 221
ILE A 403
VAL A 399
 UDP  A1424 (-3.4A)
None
None
None
 0.77A 4dx7B-2iyaA:
undetectable		 4dx7B-2iyaA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 5 GLY A 408
VAL A 235
PRO A 237
TYR A 239
 None
 1.08A 4grkA-2iyaA:
undetectable		 4grkA-2iyaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 THR A 139
GLU A 352
HIS A 328
 ZIO  A1425 (-3.7A)
ZIO  A1425 (-3.8A)
UDP  A1424 (-4.0A)
 0.90A 5xioA-2iyaA:
4.9		 5xioA-2iyaA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 THR A 139
GLU A 352
HIS A 328
 ZIO  A1425 (-3.7A)
ZIO  A1425 (-3.8A)
UDP  A1424 (-4.0A)
 0.91A 5xiqB-2iyaA:
3.9		 5xiqB-2iyaA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 THR A 139
GLU A 352
HIS A 328
 ZIO  A1425 (-3.7A)
ZIO  A1425 (-3.8A)
UDP  A1424 (-4.0A)
 0.89A 5xiqD-2iyaA:
3.1		 5xiqD-2iyaA:
23.83