SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iye'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 2iye COPPER-TRANSPORTING
ATPASE
(Sulfolobus
solfataricus) 		5 / 10 ILE A 467
VAL A 457
ALA A 442
VAL A 470
VAL A 481
 None
 0.85A 2nnjA-2iyeA:
undetectable		 2nnjA-2iyeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2iye COPPER-TRANSPORTING
ATPASE
(Sulfolobus
solfataricus) 		3 / 3 THR A 420
SER A 541
LYS A 569
 None
SO4  A1636 ( 3.8A)
SO4  A1636 (-2.9A)
 1.14A 3aocC-2iyeA:
undetectable		 3aocC-2iyeA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 2iye COPPER-TRANSPORTING
ATPASE
(Sulfolobus
solfataricus) 		4 / 7 ASP A 416
SER A 562
GLU A 545
ASP A 546
 SO4  A1636 (-4.0A)
None
None
None
 1.34A 3bc9A-2iyeA:
undetectable		 3bc9A-2iyeA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_A_IMNA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2iye COPPER-TRANSPORTING
ATPASE
(Sulfolobus
solfataricus) 		5 / 10 VAL A 403
TYR A 404
VAL A 601
TYR A 388
LEU A 392
 None
 1.45A 4jq4A-2iyeA:
undetectable		 4jq4A-2iyeA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2iye COPPER-TRANSPORTING
ATPASE
(Sulfolobus
solfataricus) 		3 / 3 ASP A 546
ASN A 563
SER A 516
 None
 0.75A 4obwA-2iyeA:
3.3		 4obwA-2iyeA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2iye COPPER-TRANSPORTING
ATPASE
(Sulfolobus
solfataricus) 		3 / 3 LEU A 421
ASP A 517
ILE A 414
 None
 0.67A 4xi3D-2iyeA:
undetectable		 4xi3D-2iyeA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2iye COPPER-TRANSPORTING
ATPASE
(Sulfolobus
solfataricus) 		3 / 3 LYS A 417
ASP A 588
ILE A 538
 None
 0.84A 5kc4E-2iyeA:
undetectable		 5kc4E-2iyeA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2iye COPPER-TRANSPORTING
ATPASE
(Sulfolobus
solfataricus) 		5 / 10 TYR A 504
ILE A 490
ILE A 485
LEU A 468
ILE A 510
 None
 1.43A 5vkqA-2iyeA:
undetectable
5vkqD-2iyeA:
undetectable		 5vkqA-2iyeA:
9.93
5vkqD-2iyeA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2iye COPPER-TRANSPORTING
ATPASE
(Sulfolobus
solfataricus) 		5 / 10 ILE A 510
TYR A 504
ILE A 490
ILE A 485
LEU A 468
 None
 1.44A 5vkqA-2iyeA:
undetectable
5vkqB-2iyeA:
undetectable		 5vkqA-2iyeA:
9.93
5vkqB-2iyeA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2iye COPPER-TRANSPORTING
ATPASE
(Sulfolobus
solfataricus) 		5 / 10 ILE A 510
TYR A 504
ILE A 490
ILE A 485
LEU A 468
 None
 1.43A 5vkqC-2iyeA:
undetectable
5vkqD-2iyeA:
undetectable		 5vkqC-2iyeA:
9.93
5vkqD-2iyeA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2iye COPPER-TRANSPORTING
ATPASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 589
ASP A 588
ALA A 604
LEU A 596
ALA A 595
 None
 1.04A 6bq4B-2iyeA:
2.6		 6bq4B-2iyeA:
14.52