SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iyf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 9 ILE A  27
LEU A 108
GLU A 396
ALA A 390
VAL A  26
 None
 1.31A 1ctrA-2iyfA:
undetectable		 1ctrA-2iyfA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 7 LEU A 296
ALA A 299
VAL A 233
VAL A 265
 None
 0.87A 1epbA-2iyfA:
undetectable		 1epbA-2iyfA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 12 GLY A 307
ALA A 308
SER A 311
GLY A 314
LEU A 315
 UDP  A1401 ( 3.9A)
UDP  A1401 (-4.3A)
None
None
None
 0.63A 1fe2A-2iyfA:
undetectable		 1fe2A-2iyfA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 8 GLU A 379
ARG A 371
VAL A 342
LEU A 340
 None
 0.94A 1fiqC-2iyfA:
undetectable		 1fiqC-2iyfA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 ASN A 133
ALA A 308
ASN A 333
 ERY  A1400 (-3.6A)
UDP  A1401 (-4.3A)
None
 0.71A 1n4fA-2iyfA:
undetectable		 1n4fA-2iyfA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 5 ASP A  87
LEU A  63
ALA A  91
LEU A  95
 None
 1.02A 1nh8A-2iyfA:
undetectable		 1nh8A-2iyfA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 12 LEU A 264
LEU A 280
ILE A 268
ILE A 295
LEU A 235
 None
 1.21A 1tw4B-2iyfA:
undetectable		 1tw4B-2iyfA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 9 THR A 359
LEU A 363
HIS A 305
ALA A 323
LEU A 196
 None
None
UDP  A1401 (-4.0A)
None
None
 1.20A 2azqA-2iyfA:
undetectable		 2azqA-2iyfA:
23.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		11 / 11 HIS A  19
TRP A  73
ASN A  80
VAL A  81
PHE A  84
ILE A 111
TYR A 114
ASN A 133
ALA A 182
SER A 183
ASP A 329
 ERY  A1400 (-3.9A)
ERY  A1400 (-3.8A)
ERY  A1400 (-3.7A)
ERY  A1400 (-4.6A)
ERY  A1400 ( 3.8A)
ERY  A1400 ( 3.8A)
None
ERY  A1400 (-3.6A)
ERY  A1400 (-3.6A)
ERY  A1400 (-2.8A)
ERY  A1400 (-4.7A)
 0.02A 2iyfA-2iyfA:
63.9		 2iyfA-2iyfA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		11 / 12 TRP A  73
ASN A  80
VAL A  81
PHE A  84
ILE A 111
TYR A 114
ASN A 133
LEU A 134
TYR A 140
ALA A 182
SER A 183
 ERY  A1400 (-3.8A)
ERY  A1400 (-3.7A)
ERY  A1400 (-4.6A)
ERY  A1400 ( 3.8A)
ERY  A1400 ( 3.8A)
None
ERY  A1400 (-3.6A)
ERY  A1400 ( 4.8A)
ERY  A1400 ( 4.5A)
ERY  A1400 (-3.6A)
ERY  A1400 (-2.8A)
 0.27A 2iyfB-2iyfA:
58.7		 2iyfB-2iyfA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		11 / 12 TRP A  73
VAL A  81
PHE A  84
ILE A 111
TYR A 114
ASN A 133
LEU A 134
TYR A 140
ALA A 182
SER A 183
ASP A 329
 ERY  A1400 (-3.8A)
ERY  A1400 (-4.6A)
ERY  A1400 ( 3.8A)
ERY  A1400 ( 3.8A)
None
ERY  A1400 (-3.6A)
ERY  A1400 ( 4.8A)
ERY  A1400 ( 4.5A)
ERY  A1400 (-3.6A)
ERY  A1400 (-2.8A)
ERY  A1400 (-4.7A)
 0.77A 2iyfB-2iyfA:
58.7		 2iyfB-2iyfA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 8 GLU A 379
ARG A 371
VAL A 342
LEU A 340
 None
 0.95A 3ax7A-2iyfA:
undetectable		 3ax7A-2iyfA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 12 ALA A 334
GLY A 332
LEU A 196
SER A 311
GLY A 307
 None
None
None
None
UDP  A1401 ( 3.9A)
 1.01A 3g2oA-2iyfA:
undetectable		 3g2oA-2iyfA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 6 LEU A  78
GLU A  82
PRO A  83
ARG A 157
 None
 1.47A 3ltwA-2iyfA:
undetectable		 3ltwA-2iyfA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 8 PRO A 132
HIS A 109
SER A  13
ILE A  14
 None
 1.10A 3sfeB-2iyfA:
undetectable
3sfeC-2iyfA:
undetectable		 3sfeB-2iyfA:
19.71
3sfeC-2iyfA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 7 GLU A 379
ARG A 371
VAL A 342
LEU A 340
 None
 0.88A 3uniA-2iyfA:
undetectable		 3uniA-2iyfA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 8 GLU A 379
ARG A 371
VAL A 342
LEU A 340
 None
 0.84A 3uniB-2iyfA:
undetectable		 3uniB-2iyfA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 12 GLY A 307
ALA A 308
SER A 311
GLY A 314
LEU A 315
 UDP  A1401 ( 3.9A)
UDP  A1401 (-4.3A)
None
None
None
 0.47A 4e1gA-2iyfA:
undetectable		 4e1gA-2iyfA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 12 GLY A 307
ALA A 308
SER A 311
GLY A 314
LEU A 315
 UDP  A1401 ( 3.9A)
UDP  A1401 (-4.3A)
None
None
None
 0.49A 4e1gB-2iyfA:
undetectable		 4e1gB-2iyfA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		11 / 11 HIS A  19
TRP A  73
ASN A  80
VAL A  81
PHE A  84
ILE A 111
TYR A 114
ASN A 133
LEU A 134
ALA A 182
SER A 183
 ERY  A1400 (-3.9A)
ERY  A1400 (-3.8A)
ERY  A1400 (-3.7A)
ERY  A1400 (-4.6A)
ERY  A1400 ( 3.8A)
ERY  A1400 ( 3.8A)
None
ERY  A1400 (-3.6A)
ERY  A1400 ( 4.8A)
ERY  A1400 (-3.6A)
ERY  A1400 (-2.8A)
 0.05A 4m83A-2iyfA:
undetectable		 4m83A-2iyfA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		11 / 11 HIS A  19
TRP A  73
ASN A  80
VAL A  81
PHE A  84
ILE A 111
TYR A 114
ASN A 133
TYR A 140
ALA A 182
SER A 183
 ERY  A1400 (-3.9A)
ERY  A1400 (-3.8A)
ERY  A1400 (-3.7A)
ERY  A1400 (-4.6A)
ERY  A1400 ( 3.8A)
ERY  A1400 ( 3.8A)
None
ERY  A1400 (-3.6A)
ERY  A1400 ( 4.5A)
ERY  A1400 (-3.6A)
ERY  A1400 (-2.8A)
 0.34A 4m83B-2iyfA:
undetectable		 4m83B-2iyfA:
99.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 SER A  13
MET A  11
ASP A  47
 None
 0.82A 4mm4B-2iyfA:
undetectable		 4mm4B-2iyfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 ASP A 329
ASN A 133
SER A  75
 ERY  A1400 (-4.7A)
ERY  A1400 (-3.6A)
None
 0.85A 4obwA-2iyfA:
4.0		 4obwA-2iyfA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 7 GLU A 313
THR A 317
GLY A 314
THR A 319
 UDP  A1401 (-2.7A)
None
None
None
 0.93A 4qwpB-2iyfA:
undetectable		 4qwpB-2iyfA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 12 ASP A 102
TYR A  99
TRP A 123
ALA A 116
ALA A 120
 None
 1.43A 5cxvA-2iyfA:
undetectable		 5cxvA-2iyfA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 THR A 304
SER A 311
ASP A 329
 None
None
ERY  A1400 (-4.7A)
 0.76A 5kvaA-2iyfA:
undetectable		 5kvaA-2iyfA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 11 THR A 304
ALA A 241
GLY A 310
GLY A 309
ALA A 308
 None
UDP  A1401 (-4.3A)
UDP  A1401 (-3.6A)
UDP  A1401 (-3.5A)
UDP  A1401 (-4.3A)
 0.98A 5lf3K-2iyfA:
undetectable
5lf3L-2iyfA:
undetectable		 5lf3K-2iyfA:
20.77
5lf3L-2iyfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 11 THR A 304
ALA A 241
GLY A 310
GLY A 309
ALA A 308
 None
UDP  A1401 (-4.3A)
UDP  A1401 (-3.6A)
UDP  A1401 (-3.5A)
UDP  A1401 (-4.3A)
 0.98A 5lf3Y-2iyfA:
undetectable
5lf3Z-2iyfA:
undetectable		 5lf3Y-2iyfA:
20.77
5lf3Z-2iyfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 11 ASP A 110
SER A  13
VAL A  31
ILE A  27
ILE A   9
 None
 1.35A 5y80A-2iyfA:
undetectable		 5y80A-2iyfA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		4 / 6 ARG A 374
ALA A 370
LEU A 373
ALA A 318
 None
 1.20A 6fosB-2iyfA:
undetectable		 6fosB-2iyfA:
12.29