SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 2iyk REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 ILE A 147
GLY A  37
GLY A  39
ILE A  18
ALA A 144
 None
None
None
ZN  A1163 ( 4.9A)
None
 1.07A 4kicB-2iykA:
undetectable		 4kicB-2iykA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2iyk REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		4 / 4 THR A  59
ARG A  79
GLU A  57
VAL A  70
 None
 1.29A 4odoC-2iykA:
undetectable		 4odoC-2iykA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2iyk REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 8 VAL A  81
ILE A 123
VAL A  25
HIS A  49
VAL A  58
 None
None
None
ZN  A1164 (-3.3A)
None
 1.38A 5l94A-2iykA:
undetectable		 5l94A-2iykA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2iyk REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		3 / 3 LEU A  84
ASN A  28
LEU A  50
 None
 0.75A 6exiD-2iykA:
undetectable		 6exiD-2iykA:
18.87