SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 6 VAL A 152
VAL A   8
ILE A 159
MET A  11
 None
 1.13A 1iepA-2iyoA:
undetectable		 1iepA-2iyoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 8 LEU A 228
GLU A 227
THR A 399
TYR A 402
 None
 1.14A 1qvtA-2iyoA:
undetectable		 1qvtA-2iyoA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 12 ILE A  70
ALA A 148
GLY A  94
LEU A  88
LEU A 115
 None
 1.11A 1rjdA-2iyoA:
3.7		 1rjdA-2iyoA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 7 LEU A 205
THR A 236
LEU A 211
SER A 212
 None
 0.88A 1tyrB-2iyoA:
undetectable		 1tyrB-2iyoA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 12 ALA A 359
ILE A 358
ILE A 376
ALA A 336
LEU A 279
 None
 1.04A 1uduB-2iyoA:
undetectable		 1uduB-2iyoA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 12 ARG A 401
ILE A 398
GLU A 227
ARG A 324
TYR A 402
 None
 1.38A 2f10A-2iyoA:
undetectable		 2f10A-2iyoA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 6 VAL A 152
VAL A   8
ILE A 159
MET A  11
 None
 1.14A 2hyyB-2iyoA:
undetectable		 2hyyB-2iyoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 8 LEU A  87
LEU A  97
ASP A  95
ASP A  92
 None
 1.09A 2j2pA-2iyoA:
undetectable
2j2pB-2iyoA:
undetectable		 2j2pA-2iyoA:
19.39
2j2pB-2iyoA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		3 / 3 PRO A 138
ASN A  21
ARG A  25
 None
 0.94A 2qeuB-2iyoA:
undetectable		 2qeuB-2iyoA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 7 ILE A  98
LEU A  97
GLY A   7
ARG A  69
 None
 0.76A 2wd9A-2iyoA:
2.7		 2wd9A-2iyoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 10 TRP A 362
PHE A 372
ARG A 363
LEU A 373
ALA A 370
 None
 1.35A 2wscB-2iyoA:
0.2		 2wscB-2iyoA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_B_PQNB1774_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 10 TRP A 362
PHE A 372
ARG A 363
LEU A 373
ALA A 370
 None
 1.34A 2wseB-2iyoA:
0.0		 2wseB-2iyoA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 11 ARG A 369
TRP A 362
LYS A 184
VAL A 183
GLU A 348
 None
None
6PG  A1471 (-2.6A)
None
None
 1.47A 3bf6H-2iyoA:
undetectable		 3bf6H-2iyoA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 4 GLY A 178
GLY A 143
GLY A 175
GLY A 180
 None
 0.63A 3bogC-2iyoA:
undetectable		 3bogC-2iyoA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 4 GLY A 178
GLY A 143
GLY A 175
GLY A 180
 None
 0.60A 3bogD-2iyoA:
undetectable		 3bogD-2iyoA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 12 GLY A  94
GLY A 119
SER A 118
LEU A  91
LEU A 151
 None
 0.86A 3cjtO-2iyoA:
8.7		 3cjtO-2iyoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 6 VAL A 152
VAL A   8
ILE A 159
MET A  11
 None
 1.14A 3k5vA-2iyoA:
undetectable		 3k5vA-2iyoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 6 VAL A 152
VAL A   8
ILE A 159
MET A  11
 None
 1.10A 3k5vB-2iyoA:
undetectable		 3k5vB-2iyoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 6 VAL A 152
VAL A   8
ILE A 159
MET A  11
 None
 1.11A 3ms9A-2iyoA:
undetectable		 3ms9A-2iyoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 7 VAL A 152
VAL A   8
ILE A 159
MET A  11
 None
 1.11A 3ms9B-2iyoA:
undetectable		 3ms9B-2iyoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 6 VAL A 152
VAL A   8
ILE A 159
MET A  11
 None
 1.14A 3mssC-2iyoA:
undetectable		 3mssC-2iyoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 6 ASP A 244
TYR A 250
ASP A 253
LYS A 254
 None
 1.26A 3pocB-2iyoA:
undetectable		 3pocB-2iyoA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 11 PHE A 312
GLU A 318
VAL A 319
ILE A 323
ILE A 420
 None
 1.26A 4drjA-2iyoA:
undetectable		 4drjA-2iyoA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 5 GLY A 338
LEU A 373
ILE A 358
LEU A 197
 None
 0.86A 4o8fA-2iyoA:
undetectable		 4o8fA-2iyoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 9 PHE A 156
ALA A 160
ALA A 161
LEU A 136
VAL A 127
 None
 1.27A 4or0A-2iyoA:
undetectable		 4or0A-2iyoA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 6 LEU A 205
THR A 236
LEU A 211
SER A 212
 None
 1.04A 4pwjA-2iyoA:
undetectable		 4pwjA-2iyoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 12 GLY A 180
ASN A 102
ILE A  98
THR A  80
ILE A  96
 None
6PG  A1471 (-2.9A)
None
None
None
 1.03A 4q5mA-2iyoA:
undetectable		 4q5mA-2iyoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 10 PHE A 312
GLU A 318
VAL A 319
ILE A 323
ILE A 420
 None
 1.22A 4qt2A-2iyoA:
undetectable		 4qt2A-2iyoA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 10 PHE A 312
GLU A 318
VAL A 319
ILE A 323
ILE A 420
 None
 1.28A 4qt3A-2iyoA:
undetectable		 4qt3A-2iyoA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		3 / 3 ARG A  69
ASP A  95
ARG A  68
 None
 0.62A 4wq4B-2iyoA:
2.6		 4wq4B-2iyoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 12 GLU A 191
GLY A 189
ILE A 190
SER A 334
GLN A 337
 6PG  A1471 (-2.7A)
None
None
None
None
 1.33A 4xudA-2iyoA:
6.8		 4xudA-2iyoA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 7 LEU A 205
THR A 236
LEU A 211
SER A 212
 None
 1.01A 5bojB-2iyoA:
undetectable		 5bojB-2iyoA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 7 GLY A  62
LEU A 115
PHE A 122
ASP A  92
 None
 0.82A 5hieB-2iyoA:
undetectable		 5hieB-2iyoA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 12 ALA A 172
MET A 174
GLY A 356
THR A 377
TYR A 335
 None
 1.11A 5igiA-2iyoA:
1.2		 5igiA-2iyoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 12 LYS A  38
GLY A  15
MET A  73
ASN A 102
LYS A 262
 None
None
None
6PG  A1471 (-2.9A)
6PG  A1471 ( 4.9A)
 1.46A 5kc0A-2iyoA:
1.4		 5kc0A-2iyoA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 8 SER A 330
THR A 422
ALA A 426
SER A 201
 None
 0.71A 5vw9A-2iyoA:
4.2		 5vw9A-2iyoA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 7 GLY A 101
GLY A 100
GLY A 124
GLY A 178
GLY A 180
 None
 1.07A 6ag0A-2iyoA:
undetectable		 6ag0A-2iyoA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 7 ILE A 208
VAL A 409
ILE A 420
THR A 424
 None
 0.96A 6cduF-2iyoA:
undetectable
6cduG-2iyoA:
undetectable		 6cduF-2iyoA:
22.58
6cduG-2iyoA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 8 ILE A 208
VAL A 409
ILE A 420
THR A 424
 None
 0.87A 6cduG-2iyoA:
undetectable
6cduH-2iyoA:
undetectable		 6cduG-2iyoA:
22.58
6cduH-2iyoA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 12 ASP A  99
GLY A 178
GLY A 124
ARG A 111
VAL A 183
 None
 1.23A 6clxA-2iyoA:
7.3		 6clxA-2iyoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		5 / 12 ARG A 401
ILE A 398
GLU A 227
ARG A 324
TYR A 402
 None
 1.32A 6ekuA-2iyoA:
undetectable		 6ekuA-2iyoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Lactococcus
lactis) 		4 / 5 GLY A 193
LEU A 197
SER A 334
TYR A 335
 None
 1.22A 6ji6A-2iyoA:
undetectable		 6ji6A-2iyoA:
19.79