SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2izo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Sulfolobus
solfataricus) 		4 / 5 ASP A  24
VAL A  75
SER A  22
ASP A 172
 MG  A1349 ( 4.3A)
None
None
None
 0.98A 1n2xB-2izoA:
2.1		 1n2xB-2izoA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Sulfolobus
solfataricus) 		3 / 3 LEU A 213
ARG A 220
ILE A 218
 None
 0.67A 2xn5B-2izoA:
undetectable		 2xn5B-2izoA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Sulfolobus
solfataricus) 		5 / 9 ARG A 183
ILE A 224
GLY A 227
ILE A 230
ILE A 174
 None
 1.10A 3ekqB-2izoA:
undetectable		 3ekqB-2izoA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Sulfolobus
solfataricus) 		6 / 9 LEU A 181
ILE A 224
GLY A 227
ILE A 230
ALA A 173
ILE A 174
 None
 1.43A 3el0B-2izoA:
undetectable		 3el0B-2izoA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 223
THR A 232
ILE A 230
LEU A   3
LEU A 175
 None
 1.16A 3k2hA-2izoA:
undetectable		 3k2hA-2izoA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A 308
GLY A 140
ILE A 141
ILE A 307
ILE A 304
 None
 1.10A 3s56B-2izoA:
undetectable		 3s56B-2izoA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A  36
LEU A  66
ALA A  28
PHE A  32
LEU A 136
 None
 1.10A 3w67C-2izoA:
undetectable		 3w67C-2izoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Sulfolobus
solfataricus) 		5 / 10 ILE A  71
LYS A 334
PRO A 142
ILE A  73
ASP A 295
 None
 1.27A 4dtaA-2izoA:
undetectable		 4dtaA-2izoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Sulfolobus
solfataricus) 		4 / 8 ILE A 211
GLU A 210
LEU A 175
LEU A 181
 None
 0.92A 4r38B-2izoA:
undetectable		 4r38B-2izoA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Sulfolobus
solfataricus) 		5 / 12 PHE A  13
LEU A  11
PRO A 204
LEU A 206
ALA A 165
 None
 0.95A 4wcxC-2izoA:
undetectable		 4wcxC-2izoA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A 175
ILE A 230
ILE A 207
GLU A 210
GLU A 151
 None
None
None
None
MG  A1349 ( 4.5A)
 1.48A 5igzA-2izoA:
undetectable		 5igzA-2izoA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Sulfolobus
solfataricus) 		5 / 9 ARG A 183
ILE A 224
GLY A 227
ILE A 230
ILE A 174
 None
 1.06A 5kqxB-2izoA:
undetectable		 5kqxB-2izoA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Sulfolobus
solfataricus) 		5 / 11 ARG A 183
ILE A 224
GLY A 227
ILE A 230
ILE A 174
 None
 1.26A 5kr2B-2izoA:
undetectable		 5kr2B-2izoA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Sulfolobus
solfataricus) 		5 / 9 ARG A 183
ILE A 224
GLY A 227
ILE A 230
ILE A 174
 None
 1.07A 5kr2D-2izoA:
undetectable		 5kr2D-2izoA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Sulfolobus
solfataricus) 		4 / 7 VAL A  21
ILE A  23
VAL A 182
ALA A 167
 None
 0.70A 5ospA-2izoA:
undetectable		 5ospA-2izoA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Sulfolobus
solfataricus) 		4 / 6 ILE A 228
LEU A 229
ARG A 220
THR A 219
 None
 1.11A 6nmfN-2izoA:
undetectable
6nmfW-2izoA:
undetectable		 6nmfN-2izoA:
20.81
6nmfW-2izoA:
13.64