SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2izp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2izp PUTATIVE MEMBRANE
ANTIGEN
(Burkholderia
pseudomallei) 		3 / 3 ASP A1176
LYS A1178
ASP A1177
 None
 0.85A 4a7tA-2izpA:
undetectable		 4a7tA-2izpA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2izp PUTATIVE MEMBRANE
ANTIGEN
(Burkholderia
pseudomallei) 		3 / 3 LYS A1181
ASN A1258
ASP A1183
 None
 0.69A 4o1eA-2izpA:
undetectable		 4o1eA-2izpA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 2izp PUTATIVE MEMBRANE
ANTIGEN
(Burkholderia
pseudomallei) 		4 / 6 SER A1166
ASP A1163
TYR A1171
LEU A1168
 None
 0.90A 4wozA-2izpA:
undetectable
4wozB-2izpA:
undetectable		 4wozA-2izpA:
24.78
4wozB-2izpA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2izp PUTATIVE MEMBRANE
ANTIGEN
(Burkholderia
pseudomallei) 		5 / 12 VAL A1292
GLY A1295
ALA A1296
SER A1298
LEU A1300
 None
 1.00A 5jvzA-2izpA:
undetectable		 5jvzA-2izpA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2izp PUTATIVE MEMBRANE
ANTIGEN
(Burkholderia
pseudomallei) 		5 / 12 VAL A1292
GLY A1295
ALA A1296
SER A1298
LEU A1300
 None
 1.11A 5kirB-2izpA:
undetectable		 5kirB-2izpA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2izp PUTATIVE MEMBRANE
ANTIGEN
(Burkholderia
pseudomallei) 		4 / 8 TYR A1254
THR A1247
TRP A1257
LEU A1242
 None
 1.50A 5kxiA-2izpA:
6.7
5kxiB-2izpA:
5.9		 5kxiA-2izpA:
21.92
5kxiB-2izpA:
21.19