SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2izv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TMX_A_BEZA881_0 (HYDROXYQUINOL 1,2-DIOXYGENASE)	2izv	SUPPRESSOR OF CYTOKINE SIGNALING 4 (Homo sapiens)	5 / 11	LEU A 310 GLY A 289 TYR A 422 ILE A 281 HIS A 391	None CL A1432 ( 4.0A) EDO A1431 ( 4.7A) None CL A1432 ( 3.8A)	1.37A	1tmxA-2izvA: undetectable	1tmxA-2izvA: 20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TMX_B_BEZB882_0 (HYDROXYQUINOL 1,2-DIOXYGENASE)	2izv	SUPPRESSOR OF CYTOKINE SIGNALING 4 (Homo sapiens)	5 / 12	LEU A 310 GLY A 289 TYR A 422 ILE A 281 HIS A 391	None CL A1432 ( 4.0A) EDO A1431 ( 4.7A) None CL A1432 ( 3.8A)	1.41A	1tmxB-2izvA: undetectable	1tmxB-2izvA: 20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C9W_A_VGHA1158_1 (7,8-DIHYDRO-8-OXOGUA NINE TRIPHOSPHATASE)	2izv	SUPPRESSOR OF CYTOKINE SIGNALING 4 (Homo sapiens)	5 / 12	LEU A 278 ASN A 282 PHE A 320 VAL A 275 ASP A 312	None None None None EDO A1431 (-3.7A)	1.14A	4c9wA-2izvA: 0.0	4c9wA-2izvA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWN_A_AQ4A602_0 (CYTOCHROME P450 1A1)	2izv	SUPPRESSOR OF CYTOKINE SIGNALING 4 (Homo sapiens)	5 / 12	SER A 323 ASN A 282 LEU A 278 GLY A 289 PHE A 387	None None None CL A1432 ( 4.0A) CL A1432 ( 4.6A)	1.35A	6dwnA-2izvA: undetectable	6dwnA-2izvA: 19.89

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1TMX_A_BEZA881_0","HYDROXYQUINOL 1,2-DIOXYGENASE","2izv","SUPPRESSOR OF CYTOKINE SIGNALING 4","Homo sapiens",5,"LEU A 310;GLY A 289;TYR A 422;ILE A 281;HIS A 391","None; CL A1432 ( 4.0A);EDO A1431 ( 4.7A);None; CL A1432 ( 3.8A)","1.37A","1tmxA-2izvA:undetectable","1tmxA-2izvA:20.60"],["1TMX_B_BEZB882_0","HYDROXYQUINOL 1,2-DIOXYGENASE","2izv","SUPPRESSOR OF CYTOKINE SIGNALING 4","Homo sapiens",5,"LEU A 310;GLY A 289;TYR A 422;ILE A 281;HIS A 391","None; CL A1432 ( 4.0A);EDO A1431 ( 4.7A);None; CL A1432 ( 3.8A)","1.41A","1tmxB-2izvA:undetectable","1tmxB-2izvA:20.60"],["4C9W_A_VGHA1158_1","7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE","2izv","SUPPRESSOR OF CYTOKINE SIGNALING 4","Homo sapiens",5,"LEU A 278;ASN A 282;PHE A 320;VAL A 275;ASP A 312","None;None;None;None;EDO A1431 (-3.7A)","1.14A","4c9wA-2izvA:0.0","4c9wA-2izvA:22.12"],["6DWN_A_AQ4A602_0","CYTOCHROME P450 1A1","2izv","SUPPRESSOR OF CYTOKINE SIGNALING 4","Homo sapiens",5,"SER A 323;ASN A 282;LEU A 278;GLY A 289;PHE A 387","None;None;None; CL A1432 ( 4.0A); CL A1432 ( 4.6A)","1.35A","6dwnA-2izvA:undetectable","6dwnA-2izvA:19.89"]]