SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2izw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 2izw RYEGRASS MOTTLE
VIRUS COAT PROTEIN
(Ryegrass
mottle
virus) 		4 / 6 PRO A 180
LEU A 183
LYS A 110
ARG A 112
 None
 1.05A 2hs2B-2izwA:
undetectable		 2hs2B-2izwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 2izw RYEGRASS MOTTLE
VIRUS COAT PROTEIN
(Ryegrass
mottle
virus) 		6 / 12 ALA A 205
ILE A 217
GLY A 215
ILE A 123
THR A 166
PRO A 165
 None
 1.38A 2nmyA-2izwA:
undetectable		 2nmyA-2izwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2izw RYEGRASS MOTTLE
VIRUS COAT PROTEIN
(Ryegrass
mottle
virus) 		4 / 7 LEU A 209
VAL A 124
GLY A 215
THR A  75
 None
 0.76A 2wd9A-2izwA:
undetectable		 2wd9A-2izwA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2izw RYEGRASS MOTTLE
VIRUS COAT PROTEIN
(Ryegrass
mottle
virus) 		4 / 8 LEU A 209
VAL A 124
GLY A 215
THR A  75
 None
 0.76A 2wd9B-2izwA:
undetectable		 2wd9B-2izwA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2izw RYEGRASS MOTTLE
VIRUS COAT PROTEIN
(Ryegrass
mottle
virus) 		5 / 10 VAL A  88
PHE A  90
SER A 102
GLY A  69
ALA A 219
 None
 1.44A 2x2iB-2izwA:
undetectable		 2x2iB-2izwA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2izw RYEGRASS MOTTLE
VIRUS COAT PROTEIN
(Ryegrass
mottle
virus) 		5 / 8 LEU A 151
ALA A 202
MET A 136
GLY A 156
LEU A 170
 None
 1.28A 2yfxA-2izwA:
undetectable		 2yfxA-2izwA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 2izw RYEGRASS MOTTLE
VIRUS COAT PROTEIN
(Ryegrass
mottle
virus) 		3 / 3 PRO A 174
PHE A 199
ALA A 116
 None
 0.65A 3itaD-2izwA:
undetectable		 3itaD-2izwA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2izw RYEGRASS MOTTLE
VIRUS COAT PROTEIN
(Ryegrass
mottle
virus) 		4 / 5 PHE A  90
TYR A 115
LEU A 183
ARG A 112
 None
 1.30A 3sudD-2izwA:
0.0		 3sudD-2izwA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2izw RYEGRASS MOTTLE
VIRUS COAT PROTEIN
(Ryegrass
mottle
virus) 		3 / 3 TYR A 108
LEU A  89
ARG A  93
 None
 0.75A 3sufB-2izwA:
undetectable		 3sufB-2izwA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 2izw RYEGRASS MOTTLE
VIRUS COAT PROTEIN
(Ryegrass
mottle
virus) 		4 / 7 LEU A 209
SER A 207
ILE A 162
VAL A 132
 None
 1.11A 4tvtA-2izwA:
undetectable		 4tvtA-2izwA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2izw RYEGRASS MOTTLE
VIRUS COAT PROTEIN
(Ryegrass
mottle
virus) 		4 / 6 ALA A 202
LEU A 137
MET A 136
LEU A 170
 None
 1.19A 4xp3A-2izwA:
undetectable		 4xp3A-2izwA:
19.03