SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		5 / 12 ASP A 231
ILE A 203
PHE A 138
ILE A 238
PHE A 127
 None
 1.15A 1c9hA-2j0aA:
undetectable		 1c9hA-2j0aA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		5 / 12 ILE A 239
ILE A 203
TYR A 166
MET A 211
ALA A 215
 None
 1.49A 1ki7A-2j0aA:
undetectable		 1ki7A-2j0aA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		5 / 12 ILE A 203
SER A 120
MET A 123
GLY A 236
TYR A 166
 None
 1.09A 1kiaA-2j0aA:
undetectable		 1kiaA-2j0aA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		4 / 8 ILE A  56
LEU A 156
LYS A 169
GLY A 168
 None
 1.04A 1os6A-2j0aA:
undetectable		 1os6A-2j0aA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		4 / 4 ASP A 231
LEU A 226
LEU A 229
LEU A 119
 None
 1.34A 1u18A-2j0aA:
undetectable		 1u18A-2j0aA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		5 / 9 GLY A 198
SER A 255
SER A 275
ASP A 144
ASP A 142
 None
 1.43A 2j2pB-2j0aA:
undetectable
2j2pC-2j0aA:
undetectable		 2j2pB-2j0aA:
22.34
2j2pC-2j0aA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		5 / 12 GLN A 271
ALA A 151
GLY A 200
LEU A 252
SER A 250
 None
 1.11A 2nv4A-2j0aA:
undetectable		 2nv4A-2j0aA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		5 / 12 GLN A 271
ALA A 151
GLY A 200
LEU A 252
SER A 250
 None
 1.01A 2nv4B-2j0aA:
undetectable		 2nv4B-2j0aA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		5 / 12 ALA A 215
GLY A 217
SER A 218
LEU A 119
ALA A 208
 None
 1.22A 3ou6C-2j0aA:
undetectable		 3ou6C-2j0aA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		5 / 12 ALA A 215
GLY A 217
SER A 218
LEU A 119
ALA A 208
 None
 1.24A 3ou7C-2j0aA:
undetectable		 3ou7C-2j0aA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		4 / 7 LEU A 155
VAL A 272
VAL A 167
LEU A 263
 None
 0.96A 3rgfA-2j0aA:
undetectable		 3rgfA-2j0aA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		4 / 8 ILE A  56
LEU A 156
LYS A 169
GLY A 168
 None
 1.00A 3selX-2j0aA:
undetectable		 3selX-2j0aA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		4 / 4 PRO A 269
LEU A 268
ILE A 286
ARG A 300
 None
 1.22A 3w1wA-2j0aA:
2.3		 3w1wA-2j0aA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		3 / 3 ASP A  72
ARG A  96
ASP A 143
 None
 0.74A 4fp9C-2j0aA:
undetectable		 4fp9C-2j0aA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		4 / 7 ILE A  56
LEU A 156
LYS A 169
GLY A 168
 None
 1.05A 4hbfA-2j0aA:
undetectable		 4hbfA-2j0aA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		4 / 8 LEU A 156
THR A 273
LEU A 153
VAL A 147
 None
 0.93A 4iizB-2j0aA:
undetectable		 4iizB-2j0aA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		4 / 8 ASP A 142
GLU A 126
VAL A 147
THR A 273
 None
 1.07A 4lnwA-2j0aA:
undetectable		 4lnwA-2j0aA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		3 / 3 ASP A 232
GLY A 198
ASP A 142
 None
 0.66A 4xdtA-2j0aA:
undetectable		 4xdtA-2j0aA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		4 / 4 LEU A 288
ILE A 286
PRO A 269
LEU A 308
 None
 1.23A 5eb3A-2j0aA:
undetectable		 5eb3A-2j0aA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 2j0a BETA-1,3-N-ACETYLGLU
COSAMINYLTRANSFERASE
MANIC FRINGE
(Mus
musculus) 		5 / 12 ASP A 231
ILE A 203
PHE A 138
ILE A 238
PHE A 127
 None
 1.15A 5hkgA-2j0aA:
undetectable		 5hkgA-2j0aA:
16.73