SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j0r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		4 / 6 VAL A 185
TRP A 189
PHE A 198
GLU A 188
 None
 1.28A 1p6mA-2j0rA:
0.0
1p6mB-2j0rA:
0.0		 1p6mA-2j0rA:
22.99
1p6mB-2j0rA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_2
(GLUCODEXTRANASE)		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		4 / 5 GLN A 316
GLU A 305
LEU A 201
TRP A 189
 None
 1.44A 1ulvA-2j0rA:
0.0		 1ulvA-2j0rA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		3 / 3 ARG A  39
TYR A   9
LYS A  13
 None
 0.92A 1uujB-2j0rA:
undetectable		 1uujB-2j0rA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		4 / 8 LEU A 338
ILE A 291
GLU A 327
ILE A 235
 None
 0.93A 2azxA-2j0rA:
undetectable		 2azxA-2j0rA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		5 / 12 THR A  36
LEU A 136
ILE A  67
VAL A  74
ALA A  21
 None
None
None
None
EDO  A1344 (-3.9A)
 1.18A 2g72B-2j0rA:
undetectable		 2g72B-2j0rA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		3 / 3 LEU A 105
ASN A  87
ARG A  52
 None
 0.79A 2qhfA-2j0rA:
undetectable		 2qhfA-2j0rA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		4 / 6 TRP A 189
PHE A 198
GLU A 188
VAL A 185
 None
 1.32A 3n5pA-2j0rA:
0.0
3n5pB-2j0rA:
0.0		 3n5pA-2j0rA:
21.89
3n5pB-2j0rA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLF_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		4 / 6 TRP A 189
PHE A 198
GLU A 188
VAL A 185
 None
 1.40A 3nlfA-2j0rA:
0.0
3nlfB-2j0rA:
0.0		 3nlfA-2j0rA:
21.89
3nlfB-2j0rA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		5 / 12 TYR A 222
ALA A 336
LEU A 338
LEU A 304
ILE A 243
 None
 1.15A 4g1bA-2j0rA:
undetectable		 4g1bA-2j0rA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		4 / 7 ARG A 276
VAL A 272
PHE A 256
GLU A  76
 None
None
None
12P  A1352 (-4.0A)
 1.49A 4jseA-2j0rA:
undetectable
4jseB-2j0rA:
undetectable		 4jseA-2j0rA:
20.82
4jseB-2j0rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		5 / 12 GLY A  79
GLU A  82
ASN A  95
ASP A 100
PHE A 256
 None
 0.93A 4u8yB-2j0rA:
undetectable		 4u8yB-2j0rA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		5 / 12 GLY A  79
GLU A  82
ASN A  95
ASP A 100
PHE A 256
 None
 0.93A 4u95B-2j0rA:
undetectable		 4u95B-2j0rA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		4 / 7 TRP A 189
PHE A 198
GLU A 188
VAL A 185
 None
 1.31A 5adeA-2j0rA:
undetectable
5adeB-2j0rA:
undetectable		 5adeA-2j0rA:
21.48
5adeB-2j0rA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		4 / 6 TRP A 189
PHE A 198
GLU A 188
VAL A 185
 None
 1.37A 5vvcC-2j0rA:
0.0
5vvcD-2j0rA:
0.0		 5vvcC-2j0rA:
20.39
5vvcD-2j0rA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		4 / 7 TRP A 189
PHE A 198
GLU A 188
VAL A 185
 None
 1.39A 5vvdA-2j0rA:
undetectable
5vvdB-2j0rA:
undetectable		 5vvdA-2j0rA:
20.39
5vvdB-2j0rA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		4 / 6 VAL A 185
TRP A 189
PHE A 198
GLU A 188
 None
 1.32A 5vvdC-2j0rA:
0.0
5vvdD-2j0rA:
0.0		 5vvdC-2j0rA:
20.39
5vvdD-2j0rA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2j0r HEMIN TRANSPORT
PROTEIN HEMS
(Yersinia
enterocolitica) 		4 / 6 VAL A 185
TRP A 189
PHE A 198
GLU A 188
 None
 1.32A 8nseA-2j0rA:
0.0
8nseB-2j0rA:
0.0		 8nseA-2j0rA:
21.89
8nseB-2j0rA:
21.89