SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2j0u ATP-DEPENDENT RNA
HELICASE DDX48
(Homo
sapiens) 		4 / 8 LEU A 331
ARG A 364
GLY A 309
MET A 311
 None
 0.96A 2po5B-2j0uA:
3.5		 2po5B-2j0uA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 2j0u ATP-DEPENDENT RNA
HELICASE DDX48
(Homo
sapiens) 		5 / 12 LEU A 184
LEU A 110
ALA A 161
ASP A 187
THR A  89
 None
 1.29A 3gwuA-2j0uA:
undetectable		 3gwuA-2j0uA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 2j0u ATP-DEPENDENT RNA
HELICASE DDX48
PROTEIN CASC3
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG A 206
HIS T 220
GLU T 219
ASP T 221
 None
 1.37A 4cevE-2j0uA:
1.8
4cevF-2j0uA:
1.8		 4cevE-2j0uA:
21.74
4cevF-2j0uA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2j0u ATP-DEPENDENT RNA
HELICASE DDX48
(Homo
sapiens) 		3 / 3 HIS A 138
VAL A  96
LEU A 126
 None
 0.61A 4m2vA-2j0uA:
undetectable		 4m2vA-2j0uA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 2j0u ATP-DEPENDENT RNA
HELICASE DDX48
(Homo
sapiens) 		3 / 3 GLY A 165
PRO A 164
ALA A 113
 None
 0.52A 4qn9B-2j0uA:
undetectable		 4qn9B-2j0uA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2j0u ATP-DEPENDENT RNA
HELICASE DDX48
(Homo
sapiens) 		3 / 3 THR A 212
HIS A 138
LEU A 176
 None
 0.81A 5axdC-2j0uA:
2.8		 5axdC-2j0uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 2j0u ATP-DEPENDENT RNA
HELICASE DDX48
(Homo
sapiens) 		4 / 5 ILE A 181
GLN A 213
THR A 212
LEU A 100
 None
 1.00A 6f3mD-2j0uA:
undetectable		 6f3mD-2j0uA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 2j0u ATP-DEPENDENT RNA
HELICASE DDX48
(Homo
sapiens) 		5 / 9 ILE A 237
ILE A  79
GLN A  71
GLU A 317
MET A 183
 None
 1.27A 6hloA-2j0uA:
undetectable		 6hloA-2j0uA:
21.16