SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j0w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		4 / 5 THR A 148
GLU A 156
HIS A 260
LEU A 207
 None
 1.17A 1d4fC-2j0wA:
undetectable		 1d4fC-2j0wA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		4 / 7 LEU A 319
SER A 321
PHE A 324
LEU A 325
 None
 0.66A 1j8uA-2j0wA:
undetectable		 1j8uA-2j0wA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		5 / 12 GLY A 200
ARG A 269
GLU A 210
ALA A 206
LEU A 207
 ASP  A 502 (-4.2A)
None
None
None
None
 1.15A 1mjqC-2j0wA:
undetectable
1mjqD-2j0wA:
undetectable		 1mjqC-2j0wA:
13.90
1mjqD-2j0wA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		5 / 12 GLY A 200
ARG A 269
GLU A 210
ALA A 206
LEU A 207
 ASP  A 502 (-4.2A)
None
None
None
None
 1.15A 1mjqI-2j0wA:
0.2
1mjqJ-2j0wA:
undetectable		 1mjqI-2j0wA:
13.90
1mjqJ-2j0wA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		4 / 6 LEU A 370
ARG A 379
THR A 312
LEU A 311
 None
 1.02A 2dysN-2j0wA:
1.8
2dysW-2j0wA:
undetectable		 2dysN-2j0wA:
23.71
2dysW-2j0wA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		5 / 11 ILE A 180
VAL A 127
LEU A 130
ARG A 131
VAL A 135
 None
 0.97A 2kawA-2j0wA:
undetectable		 2kawA-2j0wA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		4 / 8 ASP A 141
SER A 116
LEU A 120
HIS A 117
 None
 1.10A 2q0iA-2j0wA:
undetectable		 2q0iA-2j0wA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		6 / 12 ALA A  40
GLY A 183
ASP A 141
VAL A 142
ARG A 143
GLY A 200
 ASP  A 502 ( 4.7A)
None
None
None
None
ASP  A 502 (-4.2A)
 1.26A 2qe6A-2j0wA:
undetectable		 2qe6A-2j0wA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		4 / 6 ILE A 180
ILE A  44
LEU A 130
MET A  20
 None
 1.17A 3adsA-2j0wA:
undetectable		 3adsA-2j0wA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		3 / 3 PRO A 231
PHE A 448
LYS A 238
 None
 1.13A 3bjwG-2j0wA:
0.0		 3bjwG-2j0wA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		4 / 7 VAL A  33
PHE A   9
LEU A 130
ILE A 180
 None
 0.98A 3rfmA-2j0wA:
undetectable		 3rfmA-2j0wA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		4 / 8 ALA A 436
VAL A 439
LEU A 443
LEU A 388
 None
 0.84A 3roxA-2j0wA:
undetectable		 3roxA-2j0wA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		5 / 12 HIS A 260
GLY A 200
VAL A 258
SER A 338
ASP A 354
 None
ASP  A 502 (-4.2A)
ADP  A 820 (-3.7A)
None
None
 0.97A 3sudD-2j0wA:
undetectable		 3sudD-2j0wA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		4 / 7 TYR A 227
VAL A 258
ARG A 300
ALA A 301
 None
ADP  A 820 (-3.7A)
None
None
 0.93A 4lv9B-2j0wA:
undetectable		 4lv9B-2j0wA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		3 / 3 PRO A 296
ASN A 394
HIS A 425
 None
 1.03A 4ma3H-2j0wA:
undetectable
4ma3L-2j0wA:
undetectable		 4ma3H-2j0wA:
19.43
4ma3L-2j0wA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		5 / 12 PRO A 261
GLY A 197
GLY A 357
GLY A 199
GLY A 200
 None
None
None
ASP  A 502 (-3.1A)
ASP  A 502 (-4.2A)
 0.72A 4yvgA-2j0wA:
undetectable		 4yvgA-2j0wA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		4 / 5 ARG A 305
LEU A 388
PHE A 429
LEU A 341
 None
 1.21A 5iy5P-2j0wA:
undetectable
5iy5W-2j0wA:
undetectable		 5iy5P-2j0wA:
19.82
5iy5W-2j0wA:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		3 / 3 THR A 204
THR A 193
LEU A 120
 None
 0.68A 5m66D-2j0wA:
undetectable		 5m66D-2j0wA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		4 / 7 GLY A 199
SER A  39
ARG A 305
ASP A 202
 ASP  A 502 (-3.1A)
ASP  A 502 (-3.4A)
None
MG  A 900 (-3.9A)
 1.12A 5n5dB-2j0wA:
undetectable		 5n5dB-2j0wA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		5 / 12 PRO A 261
GLY A 197
GLY A 357
GLY A 199
GLY A 200
 None
None
None
ASP  A 502 (-3.1A)
ASP  A 502 (-4.2A)
 0.68A 5wyqA-2j0wA:
undetectable		 5wyqA-2j0wA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3
(Escherichia
coli) 		5 / 12 PRO A 261
GLY A 197
GLY A 357
GLY A 199
GLY A 200
 None
None
None
ASP  A 502 (-3.1A)
ASP  A 502 (-4.2A)
 0.68A 5zhmB-2j0wA:
undetectable		 5zhmB-2j0wA:
20.92