SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j1l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 2j1l RHO-RELATED
GTP-BINDING PROTEIN
RHOD
(Homo
sapiens) 		3 / 3 ASP A 132
ARG A 174
ASP A 136
 GDP  A1194 (-2.9A)
GDP  A1194 (-4.6A)
None
 0.92A 1vptA-2j1lA:
undetectable		 1vptA-2j1lA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2j1l RHO-RELATED
GTP-BINDING PROTEIN
RHOD
(Homo
sapiens) 		4 / 5 PHE A  37
LEU A  93
VAL A  20
VAL A  60
 None
 1.20A 2m56A-2j1lA:
undetectable		 2m56A-2j1lA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2j1l RHO-RELATED
GTP-BINDING PROTEIN
RHOD
(Homo
sapiens) 		3 / 3 GLY A  27
GLY A  29
THR A  31
 GDP  A1194 (-3.3A)
GDP  A1194 (-3.2A)
MG  A1195 ( 3.4A)
 0.43A 3si7B-2j1lA:
undetectable		 3si7B-2j1lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2j1l RHO-RELATED
GTP-BINDING PROTEIN
RHOD
(Homo
sapiens) 		5 / 9 VAL A  20
VAL A  21
VAL A 127
ILE A 125
ALA A 190
 None
 1.04A 4fwdA-2j1lA:
3.0		 4fwdA-2j1lA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2j1l RHO-RELATED
GTP-BINDING PROTEIN
RHOD
(Homo
sapiens) 		4 / 6 PHE A  37
LEU A  93
VAL A  20
VAL A  60
 None
 1.15A 4g3rB-2j1lA:
undetectable		 4g3rB-2j1lA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 2j1l RHO-RELATED
GTP-BINDING PROTEIN
RHOD
(Homo
sapiens) 		3 / 3 SER A 193
SER A 192
ALA A 167
 None
 0.72A 6dwnC-2j1lA:
undetectable		 6dwnC-2j1lA:
16.36