SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j1o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		4 / 8 GLU A 198
ARG A 223
ARG A 219
GLU A 152
 GOL  A1305 (-2.8A)
GOL  A1305 (-4.3A)
None
None
 0.80A 1cmaA-2j1oA:
undetectable
1cmaB-2j1oA:
undetectable		 1cmaA-2j1oA:
14.89
1cmaB-2j1oA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		3 / 3 LEU A 133
LEU A 125
MET A  87
 None
 0.71A 2itzA-2j1oA:
undetectable		 2itzA-2j1oA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		5 / 8 VAL A 202
GLU A 160
GLY A 161
ALA A 156
GLU A 216
 None
 1.48A 3aruA-2j1oA:
undetectable		 3aruA-2j1oA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		5 / 11 VAL A  81
ILE A 207
GLY A 204
LEU A 133
ALA A 149
 None
 1.20A 3kw2B-2j1oA:
undetectable		 3kw2B-2j1oA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		4 / 6 GLU A  42
LYS A  39
PRO A  37
GLU A  36
 None
 1.41A 4a7tA-2j1oA:
undetectable		 4a7tA-2j1oA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		5 / 9 VAL A 146
VAL A 147
GLU A 152
ILE A 207
SER A 142
 None
 1.23A 4fwdA-2j1oA:
undetectable		 4fwdA-2j1oA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		4 / 5 LYS A 155
LEU A 153
GLU A 152
LEU A 203
 None
 1.32A 4k4yA-2j1oA:
1.5		 4k4yA-2j1oA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		4 / 5 LYS A 155
LEU A 153
GLU A 152
LEU A 203
 None
 1.33A 4k4yI-2j1oA:
1.5		 4k4yI-2j1oA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		5 / 8 ARG A 219
ALA A 199
GLY A 204
LEU A 203
LEU A 153
 None
 1.17A 4po0A-2j1oA:
3.3		 4po0A-2j1oA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		4 / 6 HIS A  85
GLY A  52
GLU A  82
ARG A  54
 None
 1.04A 4zbqA-2j1oA:
4.0		 4zbqA-2j1oA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		4 / 7 ILE A 215
LEU A 218
GLY A 204
GLY A 205
 None
 0.71A 5a06A-2j1oA:
undetectable		 5a06A-2j1oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		4 / 7 ILE A 215
LEU A 218
GLY A 204
GLY A 205
 None
 0.72A 5a06C-2j1oA:
undetectable		 5a06C-2j1oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		4 / 7 ILE A 215
LEU A 218
GLY A 204
GLY A 205
 None
 0.72A 5a06E-2j1oA:
undetectable		 5a06E-2j1oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		4 / 7 ILE A 215
LEU A 218
GLY A 204
GLY A 205
 None
 0.74A 5a06F-2j1oA:
undetectable		 5a06F-2j1oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		5 / 12 ALA A  74
GLY A 204
LEU A  66
ALA A 199
LEU A  59
 None
 0.92A 5c0oG-2j1oA:
undetectable		 5c0oG-2j1oA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		4 / 6 ARG A 270
PRO A 261
THR A 239
ILE A 235
 None
 1.44A 5ih0A-2j1oA:
undetectable		 5ih0A-2j1oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		5 / 12 LEU A  73
GLY A 208
GLY A 209
VAL A  67
CYH A  79
 None
 1.13A 5uc1A-2j1oA:
2.4		 5uc1A-2j1oA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		5 / 12 LEU A  73
GLY A 208
GLY A 209
VAL A  67
CYH A  79
 None
 1.14A 5uc1B-2j1oA:
3.5		 5uc1B-2j1oA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2j1o GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sinapis
alba) 		3 / 3 ILE A  17
ASN A  25
CYH A  79
 None
 0.62A 6bp4A-2j1oA:
undetectable		 6bp4A-2j1oA:
21.63