SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j1q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		4 / 6 VAL A 252
VAL A 152
ILE A 230
ARG A 164
 None
 0.89A 1iepA-2j1qA:
undetectable		 1iepA-2j1qA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		4 / 7 VAL A  67
ILE A  65
GLU A  87
LEU A 331
 None
 0.98A 1j96B-2j1qA:
undetectable		 1j96B-2j1qA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		5 / 12 ILE A  86
TYR A  89
ILE A 279
ALA A 338
ASN A 327
 None
 1.07A 1jtxA-2j1qA:
undetectable		 1jtxA-2j1qA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		3 / 3 ARG A 124
VAL A 220
TRP A 221
 None
 0.89A 1qw6A-2j1qA:
undetectable		 1qw6A-2j1qA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		3 / 3 ARG A 124
VAL A 220
TRP A 221
 None
 0.85A 1qwcA-2j1qA:
undetectable		 1qwcA-2j1qA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		4 / 8 TRP A 221
ASP A 192
LEU A 195
GLY A 191
 None
 0.77A 1rtsA-2j1qA:
undetectable		 1rtsA-2j1qA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		3 / 3 ARG A 124
VAL A 220
TRP A 221
 None
 0.86A 1vagA-2j1qA:
undetectable		 1vagA-2j1qA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		5 / 12 ALA A 197
ASP A 192
SER A  56
ILE A  86
TYR A  75
 None
 1.29A 1xvaB-2j1qA:
0.0		 1xvaB-2j1qA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		3 / 3 ARG A 124
VAL A 220
TRP A 221
 None
 0.84A 1zviA-2j1qA:
undetectable		 1zviA-2j1qA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		4 / 6 VAL A 252
VAL A 152
ILE A 230
ARG A 164
 None
 0.94A 2hyyA-2j1qA:
undetectable		 2hyyA-2j1qA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		4 / 8 TRP A 221
ASP A 192
LEU A 195
GLY A 191
 None
 0.84A 2tsrB-2j1qA:
undetectable		 2tsrB-2j1qA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		4 / 5 ILE A  86
HIS A  90
TYR A  75
GLY A 276
 None
 1.12A 3b9mA-2j1qA:
undetectable		 3b9mA-2j1qA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		3 / 3 MET A 159
VAL A 152
GLU A 255
 None
 0.86A 3c6gA-2j1qA:
undetectable		 3c6gA-2j1qA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		5 / 9 GLN A  38
VAL A  35
ILE A  85
VAL A  67
VAL A  53
 None
 1.16A 3fi0D-2j1qA:
undetectable		 3fi0D-2j1qA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		5 / 9 GLN A  38
VAL A  35
ILE A  85
VAL A  67
VAL A  53
 None
 1.16A 3fi0F-2j1qA:
undetectable		 3fi0F-2j1qA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		5 / 9 GLN A  38
VAL A  35
ILE A  85
VAL A  67
VAL A  53
 None
 1.18A 3fi0J-2j1qA:
undetectable		 3fi0J-2j1qA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		5 / 9 GLN A  38
VAL A  35
ILE A  85
VAL A  67
VAL A  53
 None
 1.36A 3fi0R-2j1qA:
undetectable		 3fi0R-2j1qA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		3 / 3 ASN A 223
MET A 173
PHE A 188
 None
 1.11A 3g4lD-2j1qA:
undetectable		 3g4lD-2j1qA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		5 / 12 CYH A 271
THR A 269
LEU A  82
ILE A  65
HIS A  90
 None
 1.16A 3gwxA-2j1qA:
undetectable		 3gwxA-2j1qA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		4 / 6 ARG A 264
ASP A  88
TYR A  30
PRO A  95
 None
 1.32A 3jqaC-2j1qA:
undetectable		 3jqaC-2j1qA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 133
PHE A 259
LEU A 131
GLU A  73
ALA A  72
 None
 1.09A 3kkzA-2j1qA:
undetectable		 3kkzA-2j1qA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		4 / 7 VAL A 252
VAL A 152
ILE A 230
ARG A 164
 None
 0.86A 3mssB-2j1qA:
undetectable		 3mssB-2j1qA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		4 / 7 LEU A  82
MET A  51
LEU A  27
ILE A  86
 None
 0.97A 4okwA-2j1qA:
undetectable		 4okwA-2j1qA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		5 / 12 ASN A 274
GLY A 276
GLN A  99
LEU A 333
GLN A 307
 None
 1.38A 4p6xI-2j1qA:
undetectable		 4p6xI-2j1qA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		5 / 9 ALA A  69
GLN A  99
LEU A 331
LEU A 268
LEU A 275
 None
 1.31A 4x30A-2j1qA:
undetectable		 4x30A-2j1qA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		3 / 3 ARG A 124
VAL A 220
TRP A 221
 None
 0.82A 5fvoA-2j1qA:
undetectable		 5fvoA-2j1qA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		3 / 3 LYS A  91
LEU A 275
ILE A  85
 None
 0.69A 5kc4A-2j1qA:
undetectable		 5kc4A-2j1qA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 239
THR A 277
ILE A 279
LEU A 333
LEU A 306
 None
 1.29A 6ie8A-2j1qA:
undetectable		 6ie8A-2j1qA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 2j1q ARGININE KINASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 275
LEU A 268
SER A  74
ALA A  69
ASP A 226
 None
 1.32A 6n91A-2j1qA:
undetectable		 6n91A-2j1qA:
13.95