SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2j22 FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A  74
ALA A  36
TYR A  77
LEU A 115
TYR A 146
 None
 1.28A 1kt5A-2j22A:
undetectable		 1kt5A-2j22A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2j22 FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 8 ILE A  92
LEU A  74
ILE A  76
GLU A 142
ILE A 129
 None
None
None
CA  A1150 (-3.5A)
None
 1.26A 1linA-2j22A:
undetectable		 1linA-2j22A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 2j22 FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ARG A 128
SER A 130
TYR A  95
 None
 0.67A 2q2hA-2j22A:
undetectable
2q2hB-2j22A:
undetectable		 2q2hA-2j22A:
21.51
2q2hB-2j22A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 2j22 FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 LEU A 115
VAL A 143
ILE A  63
ILE A  93
ILE A  76
 None
 1.12A 3ekqB-2j22A:
undetectable		 3ekqB-2j22A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 2j22 FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 VAL A  37
LEU A 140
TYR A  95
VAL A 143
ILE A 129
 None
 1.25A 3frqA-2j22A:
undetectable		 3frqA-2j22A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 2j22 FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 115
VAL A 143
ILE A  63
ILE A  93
ILE A  76
 None
 1.15A 3mwsB-2j22A:
undetectable		 3mwsB-2j22A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2j22 FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 VAL A 143
ILE A 129
ARG A 128
ILE A  92
 None
 0.77A 4lv9A-2j22A:
undetectable		 4lv9A-2j22A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2j22 FUCOLECTIN-RELATED
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 VAL A 143
ILE A 129
ARG A 128
ILE A  92
 None
 0.78A 4lv9B-2j22A:
undetectable		 4lv9B-2j22A:
16.74