SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j28'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 2j28 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		3 / 3 GLU C  81
ILE C  90
ARG C  62
 None
None
G  B1817 ( 2.6A)
 0.61A 1cd2A-2j28C:
undetectable		 1cd2A-2j28C:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 2j28 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		4 / 5 LEU C 191
GLU C 193
ALA C 189
LEU C 129
 None
 1.18A 1eta1-2j28C:
undetectable		 1eta1-2j28C:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 2j28 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		4 / 5 LEU C 191
GLU C 193
ALA C 189
LEU C 129
 None
 1.13A 1eta2-2j28C:
undetectable		 1eta2-2j28C:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 2j28 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		4 / 6 LEU C 191
LEU C 129
PRO C 130
MET C 131
 None
 1.35A 1hz4A-2j28C:
undetectable		 1hz4A-2j28C:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2j28 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		4 / 8 LEU C  80
SER C 156
GLY C 126
PRO C 125
 None
 0.98A 3hcrA-2j28C:
undetectable		 3hcrA-2j28C:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 2j28 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		5 / 12 ILE C  90
ALA C 105
ILE C 115
ALA C  75
GLU C  99
 None
None
None
None
G  B1491 ( 3.5A)
 0.99A 5vceA-2j28C:
undetectable		 5vceA-2j28C:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2j28 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		3 / 3 ARG C  62
PHE C  66
ARG C  86
 G  B1817 ( 2.6A)
None
G  B1817 ( 3.3A)
 0.90A 5y9yA-2j28C:
undetectable		 5y9yA-2j28C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2j28 50S RIBOSOMAL
PROTEIN L2
(Escherichia
coli) 		4 / 6 MET C 145
GLY C 150
ALA C 154
LEU C 153
 C  B1800 ( 4.1A)
None
U  B1818 ( 3.1A)
A  B1819 ( 3.5A)
 1.09A 6fosA-2j28C:
undetectable		 6fosA-2j28C:
19.55