SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j2m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		3 / 3 TRP A 258
VAL A 218
PRO A 219
 None
 1.00A 1rh0A-2j2mA:
undetectable		 1rh0A-2j2mA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		5 / 12 VAL A 427
LEU A 331
ALA A 280
ASN A 175
MET A 176
 None
HEM  A 501 (-4.2A)
None
None
None
 1.07A 1sa1A-2j2mA:
undetectable
1sa1B-2j2mA:
undetectable		 1sa1A-2j2mA:
20.31
1sa1B-2j2mA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		5 / 12 VAL A 427
LEU A 331
ALA A 280
ASN A 175
MET A 176
 None
HEM  A 501 (-4.2A)
None
None
None
 1.11A 1sa1C-2j2mA:
undetectable
1sa1D-2j2mA:
undetectable		 1sa1C-2j2mA:
20.31
1sa1D-2j2mA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 5 LEU A 413
GLY A 411
HIS A 410
ILE A 409
 None
 0.82A 1xf1A-2j2mA:
undetectable		 1xf1A-2j2mA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 6 LEU A 413
GLY A 411
HIS A 410
ILE A 409
 None
 0.82A 1xf1B-2j2mA:
undetectable		 1xf1B-2j2mA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 7 LEU A 278
LEU A 265
ILE A 213
GLU A 328
 None
 1.01A 2qqdA-2j2mA:
undetectable
2qqdE-2j2mA:
undetectable		 2qqdA-2j2mA:
7.95
2qqdE-2j2mA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		5 / 12 LEU A 215
PHE A 117
VAL A  90
MET A  72
THR A  76
 None
 1.11A 3czhB-2j2mA:
undetectable		 3czhB-2j2mA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 4 GLU A  84
GLY A  85
THR A  86
GLU A  87
 None
 1.15A 3e9xA-2j2mA:
undetectable		 3e9xA-2j2mA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 4 ARG A 451
ASP A 152
ASP A 159
PRO A 160
 None
 1.45A 3fgrB-2j2mA:
undetectable		 3fgrB-2j2mA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 5 SER A 196
ARG A 194
ARG A 430
GLU A 426
 None
 1.34A 3k9fA-2j2mA:
undetectable
3k9fB-2j2mA:
undetectable
3k9fC-2j2mA:
undetectable		 3k9fA-2j2mA:
22.69
3k9fB-2j2mA:
22.69
3k9fC-2j2mA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		5 / 12 ASN A 209
GLY A 323
GLY A 208
LEU A  81
MET A 324
 None
 1.50A 3r24A-2j2mA:
undetectable		 3r24A-2j2mA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		3 / 3 SER A 114
PHE A  91
LYS A 116
 HEM  A 501 (-3.3A)
None
None
 0.99A 3u88A-2j2mA:
undetectable		 3u88A-2j2mA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		5 / 12 PHE A 113
GLY A 128
ALA A  62
GLY A  61
MET A 297
 None
HEM  A 501 (-3.7A)
None
None
None
 0.98A 3v3oA-2j2mA:
undetectable		 3v3oA-2j2mA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		5 / 12 PHE A 113
GLY A 128
ALA A  62
GLY A  61
MET A 297
 None
HEM  A 501 (-3.7A)
None
None
None
 1.06A 3v3oB-2j2mA:
undetectable		 3v3oB-2j2mA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 8 LEU A 260
VAL A  90
TRP A 203
LEU A 215
 None
 1.10A 3v81A-2j2mA:
undetectable		 3v81A-2j2mA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		5 / 11 PHE A 113
GLY A 128
ALA A  62
GLY A  61
MET A 297
 None
HEM  A 501 (-3.7A)
None
None
None
 1.12A 4a6nA-2j2mA:
undetectable		 4a6nA-2j2mA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 6 ALA A 188
ASN A 225
VAL A 223
GLU A 435
 None
 0.97A 4g24A-2j2mA:
1.9		 4g24A-2j2mA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 6 GLY A 128
ASP A 125
PRO A 317
ARG A 335
 HEM  A 501 (-3.7A)
None
None
HEM  A 501 (-3.5A)
 1.08A 4lajA-2j2mA:
undetectable
4lajB-2j2mA:
undetectable		 4lajA-2j2mA:
21.04
4lajB-2j2mA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 8 LEU A 260
VAL A  90
TRP A 203
LEU A 215
 None
 0.96A 4pwdA-2j2mA:
undetectable		 4pwdA-2j2mA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QOP_A_HQEA503_1
(CATALASE)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		8 / 9 ILE A  98
ASP A 109
PRO A 110
PHE A 135
LEU A 149
TYR A 163
PHE A 181
ASP A 446
 None
 0.25A 4qopA-2j2mA:
60.1		 4qopA-2j2mA:
63.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QOP_B_HQEB503_1
(CATALASE)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		8 / 9 ILE A  98
ASP A 109
PRO A 110
PHE A 135
LEU A 149
TYR A 163
PHE A 181
ASP A 446
 None
 0.26A 4qopB-2j2mA:
60.1		 4qopB-2j2mA:
63.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QOP_C_HQEC503_1
(CATALASE)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		7 / 8 ILE A  98
ASP A 109
PRO A 110
PHE A 135
LEU A 149
TYR A 163
PHE A 181
 None
 0.25A 4qopC-2j2mA:
60.1		 4qopC-2j2mA:
63.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QOP_D_HQED503_1
(CATALASE)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		8 / 9 ILE A  98
ASP A 109
PRO A 110
LEU A 149
GLN A 158
TYR A 163
PHE A 181
ASP A 446
 None
 0.22A 4qopD-2j2mA:
60.2		 4qopD-2j2mA:
63.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 8 GLU A 328
ASP A 329
SER A 200
TRP A 203
 None
 1.23A 4uhxA-2j2mA:
undetectable		 4uhxA-2j2mA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 8 GLU A 328
ASP A 329
SER A 200
TRP A 203
 None
 1.23A 4uhxA-2j2mA:
undetectable		 4uhxA-2j2mA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		3 / 3 MET A 431
GLU A 435
LEU A 439
 None
 0.75A 4v2oB-2j2mA:
undetectable		 4v2oB-2j2mA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_B_AZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		5 / 11 ASN A 175
HIS A 179
VAL A 427
LEU A 439
THR A 182
 None
 1.42A 4ygfB-2j2mA:
undetectable		 4ygfB-2j2mA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		5 / 11 ASN A 175
HIS A 179
VAL A 427
LEU A 439
THR A 182
 None
 1.43A 4ygfC-2j2mA:
undetectable		 4ygfC-2j2mA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		5 / 11 ASN A 175
HIS A 179
VAL A 427
LEU A 439
THR A 182
 None
 1.39A 4ygfD-2j2mA:
undetectable		 4ygfD-2j2mA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		5 / 12 ASN A 175
HIS A 179
VAL A 427
LEU A 439
THR A 182
 None
 1.45A 4ygfE-2j2mA:
undetectable		 4ygfE-2j2mA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_F_AZMF303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		5 / 9 ASN A 175
HIS A 179
VAL A 427
LEU A 439
THR A 182
 None
 1.43A 4ygfF-2j2mA:
undetectable		 4ygfF-2j2mA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		5 / 10 ASN A 175
HIS A 179
VAL A 427
LEU A 439
THR A 182
 None
 1.46A 4yhaH-2j2mA:
undetectable		 4yhaH-2j2mA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 7 MET A 193
HIS A  56
GLY A 128
ASN A 129
 None
HEM  A 501 (-3.3A)
HEM  A 501 (-3.7A)
HEM  A 501 (-3.6A)
 1.39A 5a5zC-2j2mA:
undetectable		 5a5zC-2j2mA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		3 / 3 LYS A 192
TRP A 258
SER A 189
 None
 1.30A 5nwwA-2j2mA:
undetectable		 5nwwA-2j2mA:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 8 TYR A 339
ASP A 329
VAL A 127
GLY A 128
 HEM  A 501 (-3.8A)
None
HEM  A 501 ( 4.8A)
HEM  A 501 (-3.7A)
 0.93A 5nzyA-2j2mA:
undetectable		 5nzyA-2j2mA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		5 / 11 PRO A 160
ILE A 180
ASP A 446
PHE A 135
THR A  96
 None
 1.48A 5tiyA-2j2mA:
undetectable		 5tiyA-2j2mA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 8 GLY A 122
GLN A 343
TYR A 351
ASP A 125
 None
HEM  A 501 (-3.9A)
None
None
 1.06A 5vlmB-2j2mA:
1.9		 5vlmB-2j2mA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 7 GLY A 122
GLN A 343
TYR A 351
ASP A 125
 None
HEM  A 501 (-3.9A)
None
None
 0.95A 5vlmE-2j2mA:
undetectable		 5vlmE-2j2mA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 2j2m CATALASE
(Exiguobacterium
oxidotolerans) 		4 / 7 GLY A 122
GLN A 343
TYR A 351
ASP A 125
 None
HEM  A 501 (-3.9A)
None
None
 1.05A 5vlmG-2j2mA:
undetectable		 5vlmG-2j2mA:
15.42