SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j3h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 6 LEU A 135
GLU A 313
ALA A 167
LEU A 171
 None
 1.17A 1etb2-2j3hA:
undetectable		 1etb2-2j3hA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		3 / 3 PHE A 299
LEU A 175
LEU A 171
 None
 0.65A 1mx1E-2j3hA:
1.7		 1mx1E-2j3hA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 8 MET A 138
SER A 287
TYR A 290
TYR A  81
 None
 1.15A 2bteA-2j3hA:
2.5		 2bteA-2j3hA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 8 MET A 138
SER A 287
TYR A 290
TYR A  81
 None
 1.08A 2bteD-2j3hA:
2.3		 2bteD-2j3hA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 5 GLN A  76
THR A  73
ALA A  71
ARG A  57
 None
 1.11A 2qhfA-2j3hA:
0.0		 2qhfA-2j3hA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 8 MET A 138
SER A 287
TYR A 290
TYR A  81
 None
 1.30A 2v0gA-2j3hA:
undetectable		 2v0gA-2j3hA:
17.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 7 TYR A 208
VAL A 233
GLY A 235
MET A 237
 None
 0.53A 2wekB-2j3hA:
36.2		 2wekB-2j3hA:
30.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 7 VAL A 233
GLY A 235
MET A 237
SER A 258
 None
 0.48A 2wekB-2j3hA:
36.2		 2wekB-2j3hA:
30.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		5 / 12 ASP A 204
VAL A 184
TYR A 182
THR A 158
ASN A 244
 None
 1.24A 2x0yA-2j3hA:
undetectable		 2x0yA-2j3hA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 7 TYR A 148
VAL A 172
CYH A 181
ILE A 228
 None
 1.27A 2xz5B-2j3hA:
undetectable
2xz5E-2j3hA:
undetectable		 2xz5B-2j3hA:
21.11
2xz5E-2j3hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 8 ILE A 228
TYR A 148
VAL A 172
CYH A 181
 None
 1.21A 2xz5A-2j3hA:
undetectable
2xz5C-2j3hA:
undetectable		 2xz5A-2j3hA:
21.11
2xz5C-2j3hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 8 ILE A 228
TYR A 148
VAL A 172
CYH A 181
 None
 1.25A 2xz5A-2j3hA:
undetectable
2xz5C-2j3hA:
undetectable		 2xz5A-2j3hA:
21.11
2xz5C-2j3hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 8 ILE A 228
TYR A 148
VAL A 172
CYH A 181
 None
 1.24A 2xz5C-2j3hA:
undetectable
2xz5D-2j3hA:
undetectable		 2xz5C-2j3hA:
21.11
2xz5D-2j3hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 8 ILE A 228
TYR A 148
VAL A 172
CYH A 181
 None
 1.26A 2xz5C-2j3hA:
undetectable
2xz5D-2j3hA:
undetectable		 2xz5C-2j3hA:
21.11
2xz5D-2j3hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 7 ILE A 228
TYR A 148
VAL A 172
CYH A 181
 None
 1.23A 2xz5D-2j3hA:
undetectable
2xz5E-2j3hA:
undetectable		 2xz5D-2j3hA:
21.11
2xz5E-2j3hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		3 / 3 PRO A 323
LEU A 326
ARG A  55
 None
 0.86A 3aqiA-2j3hA:
undetectable		 3aqiA-2j3hA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		3 / 3 SER A 162
GLY A 234
GLY A 255
 None
 0.56A 3bogA-2j3hA:
undetectable
3bogC-2j3hA:
undetectable		 3bogA-2j3hA:
undetectable
3bogC-2j3hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		3 / 3 PHE A 206
CYH A 221
PHE A 222
 None
 0.88A 3cr5X-2j3hA:
undetectable		 3cr5X-2j3hA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		5 / 10 THR A 133
TYR A 311
VAL A 168
GLY A 137
GLY A 140
 None
 1.32A 3ixlA-2j3hA:
undetectable		 3ixlA-2j3hA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 7 TYR A 131
LEU A 175
GLN A 174
PHE A 200
 None
 1.04A 3jwqC-2j3hA:
undetectable		 3jwqC-2j3hA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		3 / 3 VAL A 342
VAL A 104
SER A 110
 None
 0.68A 3n8xB-2j3hA:
undetectable		 3n8xB-2j3hA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		5 / 12 LEU A  48
ILE A 103
GLY A  82
SER A  84
LEU A 100
 None
 1.05A 3n8zB-2j3hA:
undetectable		 3n8zB-2j3hA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 6 VAL A 241
ASN A 270
TYR A 229
GLU A 231
 None
 1.19A 3q5sA-2j3hA:
undetectable		 3q5sA-2j3hA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 8 TYR A 148
VAL A 172
CYH A 181
ILE A 228
 None
 1.32A 4bqtC-2j3hA:
undetectable
4bqtD-2j3hA:
undetectable		 4bqtC-2j3hA:
21.11
4bqtD-2j3hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 7 GLY A 173
VAL A 161
TYR A 148
GLY A 146
 None
 0.85A 4forA-2j3hA:
undetectable		 4forA-2j3hA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 5 GLY A 336
ASP A 314
MET A  54
MET A  58
 None
 1.40A 5gwkA-2j3hA:
undetectable		 5gwkA-2j3hA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		3 / 3 GLY A 234
GLY A 235
GLN A 265
 None
 0.49A 5imsA-2j3hA:
2.5		 5imsA-2j3hA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 6 TYR A 290
TRP A 101
LEU A 136
LEU A 297
 None
 1.43A 5xooA-2j3hA:
undetectable		 5xooA-2j3hA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		3 / 3 VAL A  30
TYR A 109
GLU A  36
 None
 0.97A 5zmqD-2j3hA:
undetectable
5zmqE-2j3hA:
undetectable		 5zmqD-2j3hA:
20.40
5zmqE-2j3hA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		5 / 12 GLY A 235
GLY A 234
ASN A 232
CYH A 254
GLY A 255
 None
 1.15A 6gneA-2j3hA:
undetectable		 6gneA-2j3hA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 4 ASP A  22
ILE A  78
PRO A  77
LEU A  10
 None
 1.22A 6mkeB-2j3hA:
undetectable		 6mkeB-2j3hA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 4 ASP A  12
ILE A   9
PRO A  77
LEU A  10
 None
 0.97A 6mkeA-2j3hA:
undetectable		 6mkeA-2j3hA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1
(Arabidopsis
thaliana) 		4 / 4 ASP A  22
ILE A  78
PRO A  77
LEU A  10
 None
 1.28A 6mkeA-2j3hA:
undetectable		 6mkeA-2j3hA:
11.59