SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j3r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 2j3r ZGC 92866
(Danio
rerio) 		4 / 8 PHE B  98
PHE B  33
ALA B 141
LEU B 170
 None
 1.06A 1x8vA-2j3rB:
undetectable		 1x8vA-2j3rB:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2j3r ZGC 92866
(Danio
rerio) 		5 / 12 THR B 143
ILE B  89
VAL B  93
VAL B 147
LEU B  65
 None
 1.23A 1z9hD-2j3rB:
undetectable		 1z9hD-2j3rB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2j3r ZGC 92866
(Danio
rerio) 		5 / 12 ALA B 141
ALA B 140
LEU B 123
ILE B 124
LEU B  54
 None
NO3  B1177 (-3.1A)
NO3  B1177 (-4.0A)
NO3  B1177 (-4.2A)
None
 0.96A 2aclG-2j3rB:
undetectable		 2aclG-2j3rB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2j3r ZGC 92866
(Danio
rerio) 		3 / 3 ALA B 140
THR B 168
PHE B  33
 NO3  B1177 (-3.1A)
NO3  B1177 ( 3.7A)
None
 0.78A 2c6nB-2j3rB:
undetectable		 2c6nB-2j3rB:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 2j3r ZGC 92866
(Danio
rerio) 		5 / 9 LEU B  69
ILE B 150
ILE B  89
ALA B  96
LEU B  65
 None
 1.11A 2m9qA-2j3rB:
undetectable		 2m9qA-2j3rB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 2j3r ZGC 92866
(Danio
rerio) 		5 / 9 GLY B 144
THR B 143
ALA B 140
LEU B 137
THR B 168
 None
None
NO3  B1177 (-3.1A)
None
NO3  B1177 ( 3.7A)
 1.26A 2npnA-2j3rB:
undetectable		 2npnA-2j3rB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 2j3r ZGC 92866
(Danio
rerio) 		5 / 9 LEU B  86
VAL B  93
ILE B 146
GLY B 144
ILE B  89
 None
 1.11A 3ekqB-2j3rB:
undetectable		 3ekqB-2j3rB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2j3r ZGC 92866
(Danio
rerio) 		5 / 9 LEU B 105
VAL B  82
ILE B 172
LEU B 151
PHE B 174
 None
 1.42A 3fl9D-2j3rB:
undetectable		 3fl9D-2j3rB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2j3r ZGC 92866
(Danio
rerio) 		5 / 11 LEU B 170
GLY B 144
LEU B 137
ASN B 138
LEU B 123
 None
None
None
None
NO3  B1177 (-4.0A)
 1.06A 3ndvA-2j3rB:
undetectable
3ndvB-2j3rB:
undetectable		 3ndvA-2j3rB:
18.82
3ndvB-2j3rB:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2j3r ZGC 92866
(Danio
rerio) 		5 / 11 GLY B 144
LEU B 137
ASN B 138
LEU B 123
LEU B 170
 None
None
None
NO3  B1177 (-4.0A)
None
 1.08A 3ndvC-2j3rB:
undetectable
3ndvD-2j3rB:
undetectable		 3ndvC-2j3rB:
18.82
3ndvD-2j3rB:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2j3r ZGC 92866
(Danio
rerio) 		5 / 12 ILE B 172
LEU B 170
ALA B 149
THR B 152
VAL B 160
 None
 0.99A 3rukB-2j3rB:
undetectable		 3rukB-2j3rB:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2j3r ZGC 92866
(Danio
rerio) 		5 / 12 ALA B 141
ALA B 140
LEU B  54
ALA B  55
ILE B 128
 None
NO3  B1177 (-3.1A)
None
None
None
 1.05A 4nqaH-2j3rB:
undetectable		 4nqaH-2j3rB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2j3r ZGC 92866
(Danio
rerio) 		5 / 12 ALA B 141
GLY B 145
GLY B 144
PHE B  33
GLY B  58
 None
 0.92A 4o33A-2j3rB:
undetectable		 4o33A-2j3rB:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 2j3r ZGC 92866
(Danio
rerio) 		5 / 9 LEU B  86
VAL B  93
ILE B 146
GLY B 144
ILE B  89
 None
 1.11A 5kqxB-2j3rB:
undetectable		 5kqxB-2j3rB:
21.15