SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2j3s FILAMIN-A
(Homo
sapiens) 		4 / 5 SER A2180
THR A2179
GLU A2206
GLY A2208
 None
 1.30A 1icrA-2j3sA:
undetectable
1icrB-2j3sA:
undetectable		 1icrA-2j3sA:
20.89
1icrB-2j3sA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2j3s FILAMIN-A
(Homo
sapiens) 		4 / 5 GLU A2206
GLY A2208
SER A2180
THR A2179
 None
 1.30A 1icrA-2j3sA:
undetectable
1icrB-2j3sA:
undetectable		 1icrA-2j3sA:
20.89
1icrB-2j3sA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2j3s FILAMIN-A
(Homo
sapiens) 		4 / 5 SER A2180
THR A2179
GLU A2206
GLY A2208
 None
 1.32A 1icvC-2j3sA:
undetectable
1icvD-2j3sA:
undetectable		 1icvC-2j3sA:
20.89
1icvD-2j3sA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2j3s FILAMIN-A
(Homo
sapiens) 		4 / 5 GLU A2206
GLY A2208
SER A2180
THR A2179
 None
 1.29A 1icvC-2j3sA:
undetectable
1icvD-2j3sA:
undetectable		 1icvC-2j3sA:
20.89
1icvD-2j3sA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2j3s FILAMIN-A
(Homo
sapiens) 		4 / 5 GLU A2206
GLY A2208
SER A2180
THR A2179
 None
 1.30A 1kqbA-2j3sA:
undetectable
1kqbB-2j3sA:
undetectable		 1kqbA-2j3sA:
22.03
1kqbB-2j3sA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2j3s FILAMIN-A
(Homo
sapiens) 		5 / 12 LEU A2162
PRO A2181
GLY A2237
ALA A2266
GLY A2267
 None
 0.79A 3ku1A-2j3sA:
undetectable		 3ku1A-2j3sA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2j3s FILAMIN-A
(Homo
sapiens) 		5 / 12 LEU A2162
PRO A2181
GLY A2237
ALA A2266
GLY A2267
 None
 0.79A 3ku1C-2j3sA:
undetectable		 3ku1C-2j3sA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2j3s FILAMIN-A
(Homo
sapiens) 		5 / 12 LEU A2162
PRO A2181
GLY A2237
ALA A2266
GLY A2267
 None
 0.83A 3ku1G-2j3sA:
undetectable		 3ku1G-2j3sA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2j3s FILAMIN-A
(Homo
sapiens) 		3 / 3 VAL A2134
VAL A2090
SER A2088
 None
 0.63A 3n8xB-2j3sA:
undetectable		 3n8xB-2j3sA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 2j3s FILAMIN-A
(Homo
sapiens) 		4 / 5 GLY A2138
GLU A2110
GLY A2277
PRO A2111
 None
 0.93A 3onnA-2j3sA:
undetectable		 3onnA-2j3sA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 2j3s FILAMIN-A
(Homo
sapiens) 		4 / 8 THR A2263
ARG A2264
GLY A2236
PHE A2311
 DIO  A3331 ( 4.0A)
None
None
None
 0.98A 3tzfB-2j3sA:
undetectable		 3tzfB-2j3sA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2j3s FILAMIN-A
(Homo
sapiens) 		4 / 8 HIS A2315
PRO A2320
LYS A2310
ALA A2272
 None
 0.93A 4k0bB-2j3sA:
undetectable		 4k0bB-2j3sA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2j3s FILAMIN-A
(Homo
sapiens) 		4 / 8 HIS A2315
PRO A2320
LYS A2310
ALA A2272
 None
 0.95A 4l7iB-2j3sA:
undetectable		 4l7iB-2j3sA:
22.44