SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j44'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 2j44 ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 11 GLY A  43
SER A  37
ASP A  86
ASN A  82
GLY A  26
 None
None
GLC  A1230 (-2.7A)
GLC  A1229 ( 4.6A)
None
 1.48A 2hmaA-2j44A:
undetectable		 2hmaA-2j44A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 2j44 ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 TRP A  40
LEU A  74
TRP A  30
ASN A  76
 GLC  A1229 (-3.4A)
None
GLC  A1230 ( 3.7A)
None
 1.10A 3k8mA-2j44A:
undetectable		 3k8mA-2j44A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 2j44 ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 7 TRP A 137
LEU A 178
TRP A 148
LYS A 188
ASN A 193
 GLC  A1228 (-3.8A)
None
GLC  A1227 (-3.7A)
GLC  A1227 (-2.5A)
GLC  A1228 (-2.7A)
 0.82A 3k8mA-2j44A:
undetectable		 3k8mA-2j44A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 2j44 ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 7 TRP A  40
LEU A  74
TRP A  30
ASN A  76
 GLC  A1229 (-3.4A)
None
GLC  A1230 ( 3.7A)
None
 1.09A 3k8mB-2j44A:
2.2		 3k8mB-2j44A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 2j44 ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		5 / 7 TRP A 137
LEU A 178
TRP A 148
LYS A 188
ASN A 193
 GLC  A1228 (-3.8A)
None
GLC  A1227 (-3.7A)
GLC  A1227 (-2.5A)
GLC  A1228 (-2.7A)
 0.80A 3k8mB-2j44A:
2.2		 3k8mB-2j44A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2j44 ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 GLU A  19
ASN A  21
ASN A  77
ILE A  75
 None
 1.22A 3kp6A-2j44A:
undetectable
3kp6B-2j44A:
undetectable		 3kp6A-2j44A:
21.30
3kp6B-2j44A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 2j44 ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 8 TYR A 163
ARG A 119
ASP A  53
GLU A  98
 None
 1.40A 4kr4C-2j44A:
undetectable		 4kr4C-2j44A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2j44 ALKALINE
AMYLOPULLULANASE
(Streptococcus
pneumoniae) 		4 / 6 LEU A 134
SER A 133
PHE A 154
ASP A 153
 None
None
None
ZN  A1226 (-2.4A)
 1.20A 5om3A-2j44A:
undetectable
5om3B-2j44A:
undetectable		 5om3A-2j44A:
15.84
5om3B-2j44A:
9.30