SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 2j49 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 212
GLU A 215
ALA A 234
HIS A 240
 None
 1.33A 1errA-2j49A:
undetectable
1errB-2j49A:
undetectable		 1errA-2j49A:
20.70
1errB-2j49A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 2j49 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 184
GLU A 215
PHE A 237
VAL A 222
 None
 0.91A 2fl5E-2j49A:
undetectable
2fl5F-2j49A:
undetectable		 2fl5E-2j49A:
19.27
2fl5F-2j49A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2j49 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 5
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 276
ILE A 181
LEU A 268
 None
 0.69A 2kceA-2j49A:
undetectable		 2kceA-2j49A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 2j49 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 5
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 207
PHE A 182
SER A 157
 None
 0.93A 3i5uB-2j49A:
undetectable		 3i5uB-2j49A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2j49 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 5
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 160
ASN A 261
ASP A 164
 None
 0.85A 4o1eA-2j49A:
undetectable		 4o1eA-2j49A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2j49 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 208
ILE A 216
LEU A 219
ILE A 181
 None
 0.83A 6b5vA-2j49A:
undetectable
6b5vC-2j49A:
0.1		 6b5vA-2j49A:
19.31
6b5vC-2j49A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2j49 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 208
ILE A 216
LEU A 219
ILE A 181
 None
 0.84A 6b5vC-2j49A:
0.1
6b5vD-2j49A:
undetectable		 6b5vC-2j49A:
19.31
6b5vD-2j49A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2j49 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 208
ILE A 216
LEU A 219
ILE A 181
 None
 0.83A 6b5vB-2j49A:
2.3
6b5vD-2j49A:
undetectable		 6b5vB-2j49A:
19.31
6b5vD-2j49A:
19.31