SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j4b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 2j4b TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT
72/90-100 KDA
(Encephalitozoon
cuniculi) 		3 / 3 HIS A  96
GLU A  97
HIS A  94
 None
 0.81A 3ba0A-2j4bA:
undetectable		 3ba0A-2j4bA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2j4b TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT
72/90-100 KDA
(Encephalitozoon
cuniculi) 		5 / 11 LEU A 137
ASN A 138
LEU A 130
LEU A  44
LEU A  48
 None
 1.31A 3ndvA-2j4bA:
undetectable
3ndvB-2j4bA:
undetectable		 3ndvA-2j4bA:
15.32
3ndvB-2j4bA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2j4b TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT
72/90-100 KDA
(Encephalitozoon
cuniculi) 		5 / 11 LEU A  44
LEU A  48
LEU A 137
ASN A 138
LEU A 130
 None
 1.34A 3ndvA-2j4bA:
undetectable
3ndvB-2j4bA:
undetectable		 3ndvA-2j4bA:
15.32
3ndvB-2j4bA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2j4b TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT
72/90-100 KDA
(Encephalitozoon
cuniculi) 		5 / 11 LEU A 137
ASN A 138
LEU A 130
LEU A  44
LEU A  48
 None
 1.31A 3ndvC-2j4bA:
undetectable
3ndvD-2j4bA:
undetectable		 3ndvC-2j4bA:
15.32
3ndvD-2j4bA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2j4b TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT
72/90-100 KDA
(Encephalitozoon
cuniculi) 		5 / 11 LEU A  44
LEU A  48
LEU A 137
ASN A 138
LEU A 130
 None
 1.33A 3ndvC-2j4bA:
undetectable
3ndvD-2j4bA:
undetectable		 3ndvC-2j4bA:
15.32
3ndvD-2j4bA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 2j4b TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT
72/90-100 KDA
(Encephalitozoon
cuniculi) 		5 / 12 LEU A 134
LEU A 137
ASN A 138
LEU A 141
VAL A 145
 None
 1.09A 3zqtA-2j4bA:
undetectable		 3zqtA-2j4bA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 2j4b TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT
72/90-100 KDA
(Encephalitozoon
cuniculi) 		5 / 12 LEU A 134
LEU A 137
LEU A 141
VAL A 145
MET A 113
 None
 1.17A 3zqtA-2j4bA:
undetectable		 3zqtA-2j4bA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 2j4b TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT
72/90-100 KDA
(Encephalitozoon
cuniculi) 		5 / 12 LEU A 134
LEU A 137
ASN A 138
LEU A 141
MET A 113
 None
 0.96A 4fn9B-2j4bA:
undetectable		 4fn9B-2j4bA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2j4b TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT
72/90-100 KDA
(Encephalitozoon
cuniculi) 		5 / 12 LEU A 134
LEU A 137
ASN A 138
LEU A 141
MET A 113
 None
 0.95A 4ltwA-2j4bA:
undetectable		 4ltwA-2j4bA:
22.41