SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j4d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 9 GLY A 251
ASP A 104
ALA A 254
ILE A  15
GLU A  12
 None
 1.19A 1cetA-2j4dA:
undetectable		 1cetA-2j4dA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		3 / 3 MET A 380
LEU A 383
SER A 384
 None
 0.58A 1ee2A-2j4dA:
2.4		 1ee2A-2j4dA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		4 / 6 HIS A 480
LEU A 471
LEU A 474
PRO A 475
 None
 1.31A 1hz4A-2j4dA:
undetectable		 1hz4A-2j4dA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 12 LEU A 190
VAL A 187
ILE A 337
SER A 336
TYR A 331
 None
 1.14A 1s19A-2j4dA:
undetectable		 1s19A-2j4dA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 12 LEU A  50
LEU A 102
LEU A  78
GLU A 149
LEU A  74
 None
None
None
MHF  A1499 (-2.8A)
None
 1.08A 1sn5B-2j4dA:
undetectable
1sn5D-2j4dA:
undetectable		 1sn5B-2j4dA:
14.34
1sn5D-2j4dA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 12 LEU A  78
GLU A 149
LEU A  74
LEU A  50
LEU A 102
 None
MHF  A1499 (-2.8A)
None
None
None
 1.10A 1sn5B-2j4dA:
undetectable
1sn5D-2j4dA:
undetectable		 1sn5B-2j4dA:
14.34
1sn5D-2j4dA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		4 / 8 PHE A 294
CYH A 101
MET A  99
TYR A  72
 None
 1.30A 1xqlA-2j4dA:
undetectable
1xqlB-2j4dA:
undetectable		 1xqlA-2j4dA:
21.68
1xqlB-2j4dA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		4 / 8 TYR A  72
PHE A 294
CYH A 101
MET A  99
 None
 1.38A 1xqlA-2j4dA:
undetectable
1xqlB-2j4dA:
undetectable		 1xqlA-2j4dA:
21.68
1xqlB-2j4dA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 12 MET A 246
PHE A 248
ASN A 379
GLY A 278
SER A 285
 None
None
None
None
FAD  A1498 (-2.6A)
 1.29A 2e7fA-2j4dA:
undetectable		 2e7fA-2j4dA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 12 LEU A 130
GLY A 135
ALA A 136
VAL A  71
ILE A  43
 None
 0.98A 2f80A-2j4dA:
undetectable		 2f80A-2j4dA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		6 / 12 LEU A 130
GLY A 135
ALA A 136
PRO A  70
VAL A  71
ILE A  43
 None
 1.10A 2f8gB-2j4dA:
undetectable		 2f8gB-2j4dA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		4 / 7 TRP A 366
GLY A 393
CYH A 398
PHE A 416
 None
None
FAD  A1498 ( 4.6A)
FAD  A1498 ( 4.8A)
 0.97A 2qx4A-2j4dA:
undetectable
2qx4B-2j4dA:
undetectable		 2qx4A-2j4dA:
16.83
2qx4B-2j4dA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		4 / 6 LEU A 269
SER A 298
PHE A 301
ASP A  54
 None
 1.28A 2vn1B-2j4dA:
undetectable		 2vn1B-2j4dA:
16.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VTB_B_ACTB1500_0
(CRYPTOCHROME DASH)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		4 / 4 ARG A 119
PHE A 134
VAL A 223
ASP A 224
 None
 0.26A 2vtbB-2j4dA:
61.5		 2vtbB-2j4dA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 12 MET A 246
PHE A 248
ASN A 379
ILE A 396
SER A 285
 None
None
None
None
FAD  A1498 (-2.6A)
 1.23A 2ycjA-2j4dA:
undetectable		 2ycjA-2j4dA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		4 / 8 TYR A 272
PRO A 290
PHE A  97
TRP A 291
 FAD  A1498 (-4.6A)
None
None
None
 1.39A 3bjwD-2j4dA:
undetectable		 3bjwD-2j4dA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		6 / 12 LEU A 130
GLY A 135
ALA A 136
PRO A  70
VAL A  71
ILE A  43
 None
 1.04A 3bvbB-2j4dA:
undetectable		 3bvbB-2j4dA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 11 VAL A 223
ILE A  43
ILE A 126
PRO A 123
THR A 220
 None
 0.97A 3clbA-2j4dA:
undetectable		 3clbA-2j4dA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 10 VAL A 223
ILE A  43
ILE A 126
PRO A 123
THR A 220
 None
 0.96A 3clbD-2j4dA:
undetectable		 3clbD-2j4dA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		3 / 3 LEU A 269
GLU A 305
ILE A 302
 None
 0.56A 3czhA-2j4dA:
undetectable		 3czhA-2j4dA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 10 GLY A 135
ALA A 136
PRO A  70
VAL A  71
ILE A  43
 None
 0.97A 3ekyA-2j4dA:
undetectable		 3ekyA-2j4dA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		4 / 4 ARG A 443
ASP A 192
ASP A 441
PRO A 442
 None
 1.50A 3fgrB-2j4dA:
undetectable		 3fgrB-2j4dA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 11 GLY A 461
PHE A 466
ASP A 458
ALA A 454
ARG A 472
 None
 0.97A 3g88A-2j4dA:
undetectable		 3g88A-2j4dA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 11 GLY A 461
PHE A 466
ASP A 458
ALA A 454
ARG A 472
 None
 0.98A 3g88B-2j4dA:
undetectable		 3g88B-2j4dA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 12 GLY A 461
PHE A 466
ASP A 458
ALA A 454
ARG A 472
 None
 1.02A 3g89A-2j4dA:
undetectable		 3g89A-2j4dA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 11 GLY A 461
PHE A 466
ASP A 458
ALA A 454
ARG A 472
 None
 1.03A 3g89B-2j4dA:
undetectable		 3g89B-2j4dA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 12 GLY A 461
PHE A 466
ASP A 458
ALA A 454
ARG A 472
 None
 1.00A 3g8bA-2j4dA:
undetectable		 3g8bA-2j4dA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 12 GLY A 461
PHE A 466
ASP A 458
ALA A 454
ARG A 472
 None
 1.03A 3g8bB-2j4dA:
undetectable		 3g8bB-2j4dA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 11 VAL A 223
ILE A  43
ILE A 126
PRO A 123
THR A 220
 None
 0.92A 3hbbC-2j4dA:
undetectable		 3hbbC-2j4dA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 10 VAL A 223
ILE A  43
ILE A 126
PRO A 123
THR A 220
 None
 0.97A 3hbbD-2j4dA:
undetectable		 3hbbD-2j4dA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		4 / 5 SER A  65
ARG A  36
ARG A 112
GLY A 113
 None
 1.29A 3k9fA-2j4dA:
undetectable
3k9fB-2j4dA:
undetectable
3k9fC-2j4dA:
undetectable		 3k9fA-2j4dA:
21.66
3k9fB-2j4dA:
21.66
3k9fC-2j4dA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		6 / 12 LEU A 130
GLY A 135
ALA A 136
PRO A  70
VAL A  71
ILE A  43
 None
 1.12A 3tkwB-2j4dA:
undetectable		 3tkwB-2j4dA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		5 / 8 THR A  90
ASN A  48
LEU A 102
PHE A  97
GLY A  95
 None
 1.37A 4r3aA-2j4dA:
undetectable		 4r3aA-2j4dA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		4 / 8 PHE A 260
ALA A   9
LEU A  10
GLY A 257
 None
 1.01A 4xk8a-2j4dA:
undetectable		 4xk8a-2j4dA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		3 / 3 ASP A 404
VAL A 491
LEU A 362
 None
 0.51A 5e5jB-2j4dA:
undetectable		 5e5jB-2j4dA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 2j4d CRYPTOCHROME DASH
(Arabidopsis
thaliana) 		4 / 6 ARG A 198
PHE A 332
PHE A 334
THR A 176
 None
FAD  A1498 ( 4.8A)
None
None
 1.13A 5vceA-2j4dA:
undetectable		 5vceA-2j4dA:
23.26