SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A  59
GLY A  29
GLY A  30
THR A 100
LEU A 104
 None
 1.06A 1liiA-2j4gA:
2.0		 1liiA-2j4gA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		3 / 3 THR A 100
LEU A 104
LEU A 111
 None
 0.43A 1mz9C-2j4gA:
undetectable		 1mz9C-2j4gA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		5 / 10 TYR A  25
ALA A 103
PHE A 107
LEU A  41
GLY A  29
 None
 1.36A 1uhoA-2j4gA:
undetectable		 1uhoA-2j4gA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A  93
GLY A  60
ALA A  33
VAL A  85
LEU A 110
 None
 1.00A 2nyuA-2j4gA:
undetectable		 2nyuA-2j4gA:
17.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		7 / 11 ASP A 242
CYH A 278
TYR A 282
THR A 310
VAL A 314
ASN A 339
TYR A 345
 NB1  A1590 (-3.7A)
NB1  A1590 (-3.4A)
NB1  A1590 (-3.8A)
NB1  A1590 (-3.9A)
None
NB1  A1590 (-3.6A)
NB1  A1590 ( 4.8A)
 0.71A 2w4xA-2j4gA:
59.3		 2w4xA-2j4gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		10 / 11 CYH A 278
TYR A 282
THR A 310
VAL A 314
TRP A 337
ASN A 339
VAL A 342
ASP A 344
TYR A 345
ASN A 372
 NB1  A1590 (-3.4A)
NB1  A1590 (-3.8A)
NB1  A1590 (-3.9A)
None
NB1  A1590 (-3.7A)
NB1  A1590 (-3.6A)
NB1  A1590 ( 4.9A)
NB1  A1590 ( 3.0A)
NB1  A1590 ( 4.8A)
NB1  A1590 (-3.4A)
 0.45A 2w4xA-2j4gA:
59.3		 2w4xA-2j4gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		7 / 12 ASP A 242
TYR A 282
THR A 310
VAL A 314
ASN A 339
VAL A 342
ASP A 344
 NB1  A1590 (-3.7A)
NB1  A1590 (-3.8A)
NB1  A1590 (-3.9A)
None
NB1  A1590 (-3.6A)
NB1  A1590 ( 4.9A)
NB1  A1590 ( 3.0A)
 0.75A 2x0yA-2j4gA:
41.7		 2x0yA-2j4gA:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		7 / 12 LYS A 166
VAL A 314
TRP A 337
ASN A 339
VAL A 342
ASP A 344
ASN A 372
 NB1  A1590 (-3.0A)
None
NB1  A1590 (-3.7A)
NB1  A1590 (-3.6A)
NB1  A1590 ( 4.9A)
NB1  A1590 ( 3.0A)
NB1  A1590 (-3.4A)
 0.84A 2x0yA-2j4gA:
41.7		 2x0yA-2j4gA:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		8 / 12 TYR A 282
THR A 310
VAL A 314
TRP A 337
ASN A 339
VAL A 342
ASP A 344
ASN A 372
 NB1  A1590 (-3.8A)
NB1  A1590 (-3.9A)
None
NB1  A1590 (-3.7A)
NB1  A1590 (-3.6A)
NB1  A1590 ( 4.9A)
NB1  A1590 ( 3.0A)
NB1  A1590 (-3.4A)
 0.49A 2x0yA-2j4gA:
41.7		 2x0yA-2j4gA:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X0Y_B_X0TB1625_1
(O-GLCNACASE NAGJ)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		9 / 12 ASP A 242
TYR A 282
THR A 310
TRP A 337
ASN A 339
VAL A 342
ASP A 344
TYR A 345
ASN A 372
 NB1  A1590 (-3.7A)
NB1  A1590 (-3.8A)
NB1  A1590 (-3.9A)
NB1  A1590 (-3.7A)
NB1  A1590 (-3.6A)
NB1  A1590 ( 4.9A)
NB1  A1590 ( 3.0A)
NB1  A1590 ( 4.8A)
NB1  A1590 (-3.4A)
 0.67A 2x0yB-2j4gA:
41.9		 2x0yB-2j4gA:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X0Y_B_X0TB1625_1
(O-GLCNACASE NAGJ)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		7 / 12 LYS A 166
THR A 310
TRP A 337
ASN A 339
VAL A 342
ASP A 344
ASN A 372
 NB1  A1590 (-3.0A)
NB1  A1590 (-3.9A)
NB1  A1590 (-3.7A)
NB1  A1590 (-3.6A)
NB1  A1590 ( 4.9A)
NB1  A1590 ( 3.0A)
NB1  A1590 (-3.4A)
 0.72A 2x0yB-2j4gA:
41.9		 2x0yB-2j4gA:
32.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASN A 250
GLY A 209
ILE A 206
SER A 172
HIS A 207
 None
 1.24A 3bwmA-2j4gA:
undetectable		 3bwmA-2j4gA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 167
HIS A 171
HIS A 207
ASP A 242
 None
None
None
NB1  A1590 (-3.7A)
 0.86A 3c0zC-2j4gA:
undetectable		 3c0zC-2j4gA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 180
GLU A 227
TYR A 230
 None
 0.88A 3ug8A-2j4gA:
5.7		 3ug8A-2j4gA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		4 / 8 SER A 324
ILE A 323
TRP A 309
GLU A 328
 None
 1.26A 4cx7A-2j4gA:
undetectable
4cx7B-2j4gA:
undetectable		 4cx7A-2j4gA:
21.41
4cx7B-2j4gA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A  59
GLY A  29
GLY A  30
THR A 100
LEU A 104
 None
 1.09A 4k8tA-2j4gA:
undetectable		 4k8tA-2j4gA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A  59
GLY A  29
GLY A  30
THR A 100
LEU A 104
 None
 1.10A 4k93B-2j4gA:
undetectable		 4k93B-2j4gA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ASP A 168
TYR A 163
GLY A 135
ALA A 238
 None
None
NB1  A1590 (-4.8A)
None
 0.83A 4m48A-2j4gA:
2.2		 4m48A-2j4gA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A  81
GLY A  99
GLU A  61
LEU A  44
LEU A 111
 None
 1.20A 4wcxC-2j4gA:
5.0		 4wcxC-2j4gA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A 244
VAL A 342
PHE A 136
CYH A 278
 None
NB1  A1590 ( 4.9A)
None
NB1  A1590 (-3.4A)
 0.94A 5hieC-2j4gA:
undetectable		 5hieC-2j4gA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 201
VAL A 203
GLY A 368
ILE A 336
ILE A 162
 None
 1.14A 5kqyA-2j4gA:
undetectable		 5kqyA-2j4gA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASN A 250
GLY A 209
ILE A 206
SER A 172
HIS A 207
 None
 1.24A 5lsaA-2j4gA:
undetectable		 5lsaA-2j4gA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		4 / 5 HIS A  36
ASP A  96
GLY A  99
ASN A  34
 None
 1.38A 5x7pB-2j4gA:
3.5		 5x7pB-2j4gA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASN A 431
TYR A 435
VAL A 346
VAL A 342
 None
None
None
NB1  A1590 ( 4.9A)
 1.22A 6f32B-2j4gA:
undetectable		 6f32B-2j4gA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 2j4g HYALURONOGLUCOSAMINI
DASE
(Bacteroides
thetaiotaomicron) 		5 / 9 ASN A 488
ILE A 384
ILE A 382
GLN A 149
GLU A 134
 None
 1.21A 6hloA-2j4gA:
2.1		 6hloA-2j4gA:
21.00