SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j4h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2j4h DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Escherichia
coli) 		4 / 8 VAL A 120
VAL A  33
VAL A  35
LEU A 107
 None
 0.63A 1igxA-2j4hA:
undetectable		 1igxA-2j4hA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2j4h DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Escherichia
coli) 		5 / 8 LEU A 107
ILE A 135
GLU A  95
VAL A  97
ILE A 127
 None
YYY  A1175 (-4.6A)
None
None
YYY  A1175 ( 4.2A)
 1.30A 1linA-2j4hA:
undetectable		 1linA-2j4hA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2j4h DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Escherichia
coli) 		5 / 11 LEU A  99
LEU A  17
LEU A   3
LEU A 103
ARG A   2
 None
 1.02A 2ceoA-2j4hA:
undetectable		 2ceoA-2j4hA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2j4h DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Escherichia
coli) 		3 / 3 ASP A  34
ASP A 108
ASP A   5
 None
 0.74A 2igtB-2j4hA:
undetectable		 2igtB-2j4hA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2j4h DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Escherichia
coli) 		5 / 10 LEU A  99
LEU A  17
LEU A   3
LEU A 103
ARG A   2
 None
 1.11A 2riwA-2j4hA:
undetectable
2riwB-2j4hA:
undetectable		 2riwA-2j4hA:
19.33
2riwB-2j4hA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2j4h DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Escherichia
coli) 		5 / 12 PHE A 160
LEU A  17
ILE A 155
ILE A  19
LEU A 107
 None
 1.11A 5h8tA-2j4hA:
undetectable		 5h8tA-2j4hA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2j4h DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Escherichia
coli) 		5 / 9 LEU A  17
ILE A   8
PRO A  23
VAL A  33
ILE A  19
 None
 1.22A 6ef6A-2j4hA:
undetectable		 6ef6A-2j4hA:
20.86