SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		4 / 6 SER A 221
VAL A 201
GLY A 143
GLU A 182
 None
 1.04A 1fduD-2j4lA:
undetectable		 1fduD-2j4lA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		4 / 5 GLU A  61
LEU A  67
LEU A  64
LEU A  66
 None
 1.16A 1np1A-2j4lA:
undetectable		 1np1A-2j4lA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		3 / 3 SER A  26
VAL A 136
LEU A   5
 None
 0.72A 1yajG-2j4lA:
undetectable		 1yajG-2j4lA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		4 / 8 ILE A   4
GLY A  38
PHE A  98
PHE A 113
 None
 0.80A 2vctB-2j4lA:
undetectable		 2vctB-2j4lA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		4 / 7 ILE A   4
GLY A  38
PHE A  98
PHE A 113
 None
 0.81A 2vctD-2j4lA:
undetectable		 2vctD-2j4lA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		4 / 8 ASN A 208
SER A  26
PHE A  11
ASN A  19
 None
 1.14A 2wekB-2j4lA:
3.1		 2wekB-2j4lA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		5 / 9 ILE A  51
GLY A  68
TYR A  50
GLY A  43
ARG A  49
 None
UTP  A1227 (-3.2A)
None
UTP  A1227 (-3.6A)
None
 1.36A 2y7wA-2j4lA:
undetectable		 2y7wA-2j4lA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		5 / 9 ILE A  51
GLY A  68
TYR A  50
GLY A  44
ARG A  49
 None
UTP  A1227 (-3.2A)
None
None
None
 1.20A 2y7wA-2j4lA:
undetectable		 2y7wA-2j4lA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		3 / 3 ASN A  75
ASP A  13
ARG A  55
 None
 0.86A 3k13A-2j4lA:
undetectable		 3k13A-2j4lA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		4 / 8 LEU A   5
VAL A 107
VAL A  79
LEU A  30
 None
 1.08A 3v81C-2j4lA:
undetectable		 3v81C-2j4lA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A 214
SER A 132
THR A 134
LEU A 135
ILE A 200
 None
 1.00A 4ubsA-2j4lA:
undetectable		 4ubsA-2j4lA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		5 / 8 ILE A 189
VAL A 192
VAL A  37
ILE A  27
ILE A   7
 None
 1.39A 5hi2A-2j4lA:
undetectable		 5hi2A-2j4lA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		4 / 5 SER A 132
SER A 131
SER A 130
SER A 195
 None
 1.33A 5hswA-2j4lA:
undetectable		 5hswA-2j4lA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		3 / 3 LYS A 106
LEU A  30
ILE A  39
 None
 0.72A 5kc4A-2j4lA:
undetectable		 5kc4A-2j4lA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		4 / 7 PRO A 149
TYR A 145
SER A   8
ASN A 140
 None
None
UTP  A1227 (-3.6A)
None
 1.12A 5l1fC-2j4lA:
3.0		 5l1fC-2j4lA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		4 / 8 ALA A 127
VAL A 126
THR A 119
GLY A  38
 None
None
UTP  A1227 (-2.8A)
None
 0.86A 5v0vA-2j4lA:
2.2		 5v0vA-2j4lA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2j4l URIDYLATE KINASE
(Sulfolobus
solfataricus) 		4 / 7 ALA A 138
ASP A 212
ILE A 213
ASP A 142
 None
 0.97A 6fbnA-2j4lA:
undetectable		 6fbnA-2j4lA:
20.72