SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j4r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 10 ALA A  96
GLU A  97
LEU A 100
ILE A  64
LEU A  45
 None
 1.36A 1a52A-2j4rA:
undetectable		 1a52A-2j4rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 10 ALA A  96
GLU A  97
LEU A 100
ILE A  64
LEU A  45
 None
 1.38A 1a52B-2j4rA:
undetectable		 1a52B-2j4rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 10 LEU A  45
ILE A  60
GLU A 101
LEU A 100
VAL A 111
 None
 1.17A 1cqpA-2j4rA:
undetectable
1cqpB-2j4rA:
undetectable		 1cqpA-2j4rA:
21.54
1cqpB-2j4rA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 12 ALA A  93
LEU A 100
PHE A  99
ILE A  16
LEU A  67
 None
 1.08A 1dreA-2j4rA:
undetectable		 1dreA-2j4rA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 9 ALA A  96
GLU A  97
LEU A 100
ILE A  64
LEU A  45
 None
 1.41A 1ereA-2j4rA:
undetectable		 1ereA-2j4rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 9 ALA A  96
GLU A  97
LEU A 100
ILE A  64
LEU A  45
 None
 1.41A 1ereB-2j4rA:
undetectable		 1ereB-2j4rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 9 ALA A  96
GLU A  97
LEU A 100
ILE A  64
LEU A  45
 None
 1.42A 1ereC-2j4rA:
undetectable		 1ereC-2j4rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 9 ALA A  96
GLU A  97
LEU A 100
ILE A  64
LEU A  45
 None
 1.39A 1ereD-2j4rA:
undetectable		 1ereD-2j4rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 11 ILE A  16
ALA A  84
VAL A 111
LEU A  55
ALA A  96
 None
 1.22A 1n4hA-2j4rA:
undetectable		 1n4hA-2j4rA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 10 ALA A  96
GLU A  97
LEU A 100
ILE A  64
LEU A  45
 None
 1.42A 1qkuA-2j4rA:
undetectable		 1qkuA-2j4rA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 10 ALA A  96
GLU A  97
LEU A 100
ILE A  64
LEU A  45
 None
 1.43A 1qkuB-2j4rA:
undetectable		 1qkuB-2j4rA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 10 ALA A  96
GLU A  97
LEU A 100
ILE A  64
LEU A  45
 None
 1.43A 1qkuC-2j4rA:
undetectable		 1qkuC-2j4rA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 8 ASP A 141
ILE A 165
GLY A 166
GLY A 145
PRO A 116
 None
 1.27A 1sguA-2j4rA:
undetectable		 1sguA-2j4rA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 12 VAL A 127
ALA A 123
THR A 214
ILE A 213
LEU A 290
 None
 1.06A 2oipA-2j4rA:
undetectable		 2oipA-2j4rA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		4 / 5 VAL A 207
VAL A 139
THR A 214
THR A 205
 None
 1.24A 3bjwG-2j4rA:
undetectable		 3bjwG-2j4rA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		4 / 5 VAL A 207
VAL A 139
THR A 214
THR A 205
 None
 1.29A 3bjwD-2j4rA:
undetectable		 3bjwD-2j4rA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 12 HIS A 232
GLY A 233
GLY A 208
ALA A 126
ALA A 123
 None
 1.08A 3keeA-2j4rA:
undetectable		 3keeA-2j4rA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		4 / 8 ASP A 141
GLY A 210
GLU A 148
ARG A  22
 None
G4P  A1307 ( 3.7A)
None
G4P  A1307 (-3.5A)
 1.02A 3s3nA-2j4rA:
undetectable		 3s3nA-2j4rA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 12 HIS A 232
GLY A 233
GLY A 208
ALA A 126
ALA A 123
 None
 1.10A 3sudA-2j4rA:
undetectable		 3sudA-2j4rA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 11 HIS A 232
GLY A 233
GLY A 208
ALA A 126
ALA A 123
 None
 1.10A 3sufC-2j4rA:
undetectable		 3sufC-2j4rA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 12 HIS A 232
GLY A 233
GLY A 208
ALA A 126
ALA A 123
 None
 1.02A 3sufD-2j4rA:
undetectable		 3sufD-2j4rA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		3 / 3 ARG A 121
GLU A 119
THR A 115
 None
G4P  A1307 ( 4.5A)
None
 0.78A 3v4tA-2j4rA:
undetectable		 3v4tA-2j4rA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 12 LEU A 219
GLU A 264
VAL A 263
THR A 214
GLY A 296
 None
G4P  A1307 ( 3.7A)
None
None
None
 1.24A 4q15A-2j4rA:
undetectable		 4q15A-2j4rA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		4 / 5 GLU A 299
GLY A 210
SER A 293
GLY A 208
 None
G4P  A1307 ( 3.7A)
None
None
 1.12A 5kprA-2j4rA:
5.6		 5kprA-2j4rA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		4 / 8 LEU A 290
LEU A 209
ILE A 165
THR A 147
 None
 1.05A 5ljbA-2j4rA:
undetectable		 5ljbA-2j4rA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		4 / 8 ALA A  84
VAL A 111
PHE A  99
THR A  87
 None
None
None
G4P  A1307 (-3.7A)
 0.84A 5v0vA-2j4rA:
undetectable		 5v0vA-2j4rA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 7 GLY A 211
GLY A 210
GLY A 143
GLY A 145
GLY A 144
 G4P  A1307 (-3.8A)
G4P  A1307 ( 3.7A)
G4P  A1307 ( 3.7A)
None
G4P  A1307 ( 4.7A)
 1.08A 6ag0A-2j4rA:
undetectable		 6ag0A-2j4rA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 2j4r EXOPOLYPHOSPHATASE
(Aquifex
aeolicus) 		5 / 10 ALA A  96
GLU A  97
LEU A 100
ILE A  64
LEU A  45
 None
 1.41A 6cbzB-2j4rA:
undetectable		 6cbzB-2j4rA:
14.80