SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OXR_A_AINA141_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 2j4x MITOGEN
(Streptococcus
dysgalactiae) 		4 / 4 LEU A 155
GLY A 165
ASP A 180
TYR A 156
 None
GOL  A1213 (-4.4A)
GOL  A1213 (-2.5A)
None
 1.45A 1oxrA-2j4xA:
undetectable		 1oxrA-2j4xA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2j4x MITOGEN
(Streptococcus
dysgalactiae) 		4 / 7 LYS A 103
LEU A 104
GLN A 130
PHE A 129
 None
 1.02A 2dysC-2j4xA:
undetectable
2dysJ-2j4xA:
undetectable		 2dysC-2j4xA:
17.80
2dysJ-2j4xA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2j4x MITOGEN
(Streptococcus
dysgalactiae) 		5 / 9 GLU A 191
ILE A 193
ILE A 139
LYS A 177
ILE A 169
 None
 1.22A 2j9dA-2j4xA:
0.0
2j9dB-2j4xA:
undetectable
2j9dC-2j4xA:
0.0		 2j9dA-2j4xA:
19.90
2j9dB-2j4xA:
19.90
2j9dC-2j4xA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2j4x MITOGEN
(Streptococcus
dysgalactiae) 		5 / 10 GLU A 191
ILE A 193
ILE A 139
LYS A 177
ILE A 169
 None
 1.23A 2j9dD-2j4xA:
undetectable
2j9dE-2j4xA:
undetectable
2j9dF-2j4xA:
0.0		 2j9dD-2j4xA:
19.90
2j9dE-2j4xA:
18.87
2j9dF-2j4xA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2j4x MITOGEN
(Streptococcus
dysgalactiae) 		5 / 10 LYS A 177
ILE A 169
GLU A 191
ILE A 193
ILE A 139
 None
 1.21A 2j9dD-2j4xA:
undetectable
2j9dE-2j4xA:
undetectable
2j9dF-2j4xA:
0.0		 2j9dD-2j4xA:
19.90
2j9dE-2j4xA:
18.87
2j9dF-2j4xA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_H_ACTH1113_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2j4x MITOGEN
(Streptococcus
dysgalactiae) 		5 / 9 GLU A 191
ILE A 193
ILE A 139
LYS A 177
ILE A 169
 None
 1.22A 2j9dG-2j4xA:
0.0
2j9dH-2j4xA:
0.0
2j9dI-2j4xA:
undetectable		 2j9dG-2j4xA:
19.90
2j9dH-2j4xA:
19.90
2j9dI-2j4xA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_H_ACTH1113_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2j4x MITOGEN
(Streptococcus
dysgalactiae) 		5 / 9 ILE A 139
LYS A 177
ILE A 169
GLU A 191
ILE A 193
 None
 1.25A 2j9dG-2j4xA:
0.0
2j9dH-2j4xA:
0.0
2j9dI-2j4xA:
undetectable		 2j9dG-2j4xA:
19.90
2j9dH-2j4xA:
19.90
2j9dI-2j4xA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_H_ACTH1113_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2j4x MITOGEN
(Streptococcus
dysgalactiae) 		5 / 9 LYS A 177
ILE A 169
GLU A 191
ILE A 193
ILE A 139
 None
 1.23A 2j9dG-2j4xA:
0.0
2j9dH-2j4xA:
0.0
2j9dI-2j4xA:
undetectable		 2j9dG-2j4xA:
19.90
2j9dH-2j4xA:
19.90
2j9dI-2j4xA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2j4x MITOGEN
(Streptococcus
dysgalactiae) 		4 / 6 GLU A 191
PHE A 136
TYR A 171
HIS A 170
 None
None
None
ZN  A1211 (-3.1A)
 1.22A 4a97I-2j4xA:
undetectable		 4a97I-2j4xA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2j4x MITOGEN
(Streptococcus
dysgalactiae) 		4 / 5 GLU A 191
PHE A 136
TYR A 171
HIS A 170
 None
None
None
ZN  A1211 (-3.1A)
 1.22A 4a97J-2j4xA:
0.0		 4a97J-2j4xA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 2j4x MITOGEN
(Streptococcus
dysgalactiae) 		4 / 6 LEU A 205
ASN A 206
LEU A 181
VAL A   3
 None
None
None
GOL  A1213 ( 4.7A)
 1.08A 4okbA-2j4xA:
undetectable		 4okbA-2j4xA:
19.92