SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2j59 RHO-GTPASE
ACTIVATING PROTEIN
10
(Homo
sapiens) 		3 / 3 VAL M 962
GLY M 935
LYS M 933
 None
 0.77A 4k50A-2j59M:
undetectable		 4k50A-2j59M:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2j59 RHO-GTPASE
ACTIVATING PROTEIN
10
(Homo
sapiens) 		3 / 3 VAL M 962
GLY M 935
LYS M 933
 None
 0.72A 4k50E-2j59M:
undetectable		 4k50E-2j59M:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 2j59 RHO-GTPASE
ACTIVATING PROTEIN
10
(Homo
sapiens) 		4 / 7 LYS M 931
SER M 968
TYR M 970
ARG M 965
 None
 1.49A 4l64A-2j59M:
undetectable		 4l64A-2j59M:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 2j59 RHO-GTPASE
ACTIVATING PROTEIN
10
(Homo
sapiens) 		4 / 6 ARG M1009
THR M1002
GLU M1001
SER M1000
 None
SO4  M2064 (-3.5A)
None
None
 1.08A 5ny7A-2j59M:
undetectable		 5ny7A-2j59M:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2j59 RHO-GTPASE
ACTIVATING PROTEIN
10
(Homo
sapiens) 		3 / 3 VAL M 963
ALA M 931
GLN M 978
 None
 0.58A 6gb9A-2j59M:
undetectable		 6gb9A-2j59M:
17.98