SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 8 ILE A  45
ILE A 307
GLU A 238
VAL A 241
ILE A 232
 ILE  A  45 ( 0.7A)
ILE  A 307 ( 0.7A)
GLU  A 238 ( 0.6A)
VAL  A 241 ( 0.6A)
ILE  A 232 ( 0.7A)
 1.45A 1linA-2j5bA:
undetectable		 1linA-2j5bA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 PRO A 258
ILE A 259
VAL A 303
ILE A 232
LEU A 267
 PRO  A 258 ( 1.1A)
ILE  A 259 ( 0.7A)
VAL  A 303 ( 0.6A)
ILE  A 232 ( 0.7A)
LEU  A 267 ( 0.6A)
 1.15A 1z9hD-2j5bA:
2.7		 1z9hD-2j5bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 10 ILE A 194
ALA A 193
ILE A 179
GLU A  16
ILE A 206
 ILE  A 194 ( 0.7A)
ALA  A 193 ( 0.0A)
ILE  A 179 ( 0.7A)
GLU  A  16 ( 0.6A)
ILE  A 206 ( 0.6A)
 1.35A 2dm6A-2j5bA:
2.1
2dm6B-2j5bA:
2.2		 2dm6A-2j5bA:
22.45
2dm6B-2j5bA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 ILE A  30
GLN A  64
GLY A  62
LEU A   8
 ILE  A  30 ( 0.7A)
GLN  A  64 ( 0.6A)
GLY  A  62 ( 0.0A)
LEU  A   8 ( 0.6A)
 0.88A 3bjwB-2j5bA:
undetectable		 3bjwB-2j5bA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 ILE A  30
GLN A  64
GLY A  62
LEU A   8
 ILE  A  30 ( 0.7A)
GLN  A  64 ( 0.6A)
GLY  A  62 ( 0.0A)
LEU  A   8 ( 0.6A)
 0.92A 3bjwH-2j5bA:
undetectable		 3bjwH-2j5bA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 GLU A 125
LEU A 128
ASP A 129
 GLU  A 125 ( 0.6A)
LEU  A 128 ( 0.6A)
ASP  A 129 ( 0.6A)
 0.31A 3ko0A-2j5bA:
undetectable		 3ko0A-2j5bA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 GLU A 125
LEU A 128
ASP A 129
 GLU  A 125 ( 0.6A)
LEU  A 128 ( 0.6A)
ASP  A 129 ( 0.6A)
 0.24A 3ko0T-2j5bA:
undetectable		 3ko0T-2j5bA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 11 LEU A  49
ILE A 232
ILE A 263
ILE A 310
ILE A  45
 LEU  A  49 ( 0.6A)
ILE  A 232 ( 0.7A)
ILE  A 263 ( 0.7A)
ILE  A 310 ( 0.7A)
ILE  A  45 ( 0.7A)
 1.06A 3s53B-2j5bA:
undetectable		 3s53B-2j5bA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 ARG A  92
GLU A  96
PHE A 318
 ARG  A  92 ( 0.6A)
GLU  A  96 ( 0.6A)
PHE  A 318 ( 1.3A)
 0.96A 4kszA-2j5bA:
undetectable		 4kszA-2j5bA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 8 LEU A 182
ASN A 190
MET A 127
ILE A 204
 LEU  A 182 (-0.6A)
ASN  A 190 ( 0.6A)
MET  A 127 ( 0.0A)
ILE  A 204 ( 0.7A)
 0.87A 4ok1A-2j5bA:
undetectable		 4ok1A-2j5bA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ILE A  66
ALA A  33
THR A  51
ILE A 103
ILE A  67
 ILE  A  66 ( 0.4A)
ALA  A  33 ( 0.0A)
THR  A  51 ( 0.8A)
ILE  A 103 ( 0.7A)
ILE  A  67 ( 0.7A)
 1.08A 4x5jA-2j5bA:
undetectable		 4x5jA-2j5bA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 6 GLY A 230
ASP A 227
GLY A 218
ARG A 247
 GLY  A 230 ( 0.0A)
ASP  A 227 ( 0.5A)
GLY  A 218 ( 0.0A)
ARG  A 247 ( 0.6A)
 0.92A 4z53A-2j5bA:
undetectable
4z53B-2j5bA:
1.8		 4z53A-2j5bA:
17.36
4z53B-2j5bA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ILE A  66
ALA A  33
THR A  51
ILE A 103
ILE A  67
 ILE  A  66 ( 0.4A)
ALA  A  33 ( 0.0A)
THR  A  51 ( 0.8A)
ILE  A 103 ( 0.7A)
ILE  A  67 ( 0.7A)
 1.10A 5e8qA-2j5bA:
undetectable		 5e8qA-2j5bA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 5 ILE A  67
LEU A  90
GLY A  91
PHE A  94
 ILE  A  67 ( 0.7A)
LEU  A  90 ( 0.6A)
GLY  A  91 ( 0.0A)
PHE  A  94 ( 1.3A)
 0.87A 5kmdC-2j5bA:
undetectable
5kmdD-2j5bA:
undetectable		 5kmdC-2j5bA:
22.87
5kmdD-2j5bA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 6 ILE A  11
ILE A  45
LEU A 213
HIS A 211
 ILE  A  11 ( 0.7A)
ILE  A  45 ( 0.7A)
LEU  A 213 ( 0.6A)
HIS  A 211 ( 1.0A)
 0.99A 5vkqB-2j5bA:
undetectable
5vkqC-2j5bA:
undetectable		 5vkqB-2j5bA:
12.28
5vkqC-2j5bA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 6 ILE A  11
ILE A  45
LEU A 213
HIS A 211
 ILE  A  11 ( 0.7A)
ILE  A  45 ( 0.7A)
LEU  A 213 ( 0.6A)
HIS  A 211 ( 1.0A)
 0.96A 5vkqC-2j5bA:
undetectable
5vkqD-2j5bA:
undetectable		 5vkqC-2j5bA:
12.28
5vkqD-2j5bA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A 172
ILE A 177
GLY A 176
ILE A 111
ILE A  66
 LEU  A 172 ( 0.6A)
ILE  A 177 ( 0.7A)
GLY  A 176 ( 0.0A)
ILE  A 111 ( 0.7A)
ILE  A  66 ( 0.4A)
 1.07A 6emuB-2j5bA:
3.2		 6emuB-2j5bA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 LYS A 220
SER A 215
SER A 217
 LYS  A 220 ( 0.0A)
SER  A 215 ( 0.0A)
SER  A 217 ( 0.0A)
 1.00A 6gbfA-2j5bA:
3.2		 6gbfA-2j5bA:
22.53