SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		3 / 3 VAL A 247
TRP A 245
TRP A 533
 None
 1.30A 1c4dA-2j5cA:
undetectable
1c4dB-2j5cA:
undetectable		 1c4dA-2j5cA:
4.51
1c4dB-2j5cA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		4 / 8 SER A 149
ASP A 146
GLU A 110
GLU A 102
 None
 1.15A 1knyA-2j5cA:
undetectable
1knyB-2j5cA:
undetectable		 1knyA-2j5cA:
18.66
1knyB-2j5cA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		5 / 12 ARG A 558
ASN A 338
GLY A 448
SER A 481
ILE A 451
 None
 1.36A 1q8jA-2j5cA:
undetectable		 1q8jA-2j5cA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		4 / 7 LYS A  96
GLU A 127
LEU A 272
ALA A  89
 None
 1.10A 1sn0B-2j5cA:
undetectable
1sn0D-2j5cA:
undetectable		 1sn0B-2j5cA:
12.27
1sn0D-2j5cA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		4 / 8 TYR A 420
THR A 342
CYH A 382
LEU A 304
 None
BME  A1593 (-3.7A)
None
None
 1.13A 1uw6A-2j5cA:
undetectable
1uw6B-2j5cA:
undetectable		 1uw6A-2j5cA:
16.78
1uw6B-2j5cA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		4 / 8 LEU A 304
TYR A 420
THR A 342
CYH A 382
 None
None
BME  A1593 (-3.7A)
None
 1.13A 1uw6P-2j5cA:
undetectable
1uw6T-2j5cA:
undetectable		 1uw6P-2j5cA:
16.78
1uw6T-2j5cA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		4 / 4 ILE A 120
ASP A  93
LEU A  99
ARG A 325
 None
None
None
BME  A1592 ( 4.0A)
 1.45A 2a7qA-2j5cA:
undetectable		 2a7qA-2j5cA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		5 / 9 LEU A 386
LEU A 340
ILE A 337
PHE A 389
LEU A 409
 None
 1.13A 2f7aB-2j5cA:
undetectable		 2f7aB-2j5cA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		5 / 11 ARG A 325
ILE A  92
PHE A 124
LEU A 272
ASP A 276
 BME  A1592 ( 4.0A)
None
None
None
None
 0.84A 2q6hA-2j5cA:
undetectable		 2q6hA-2j5cA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		5 / 12 ARG A 325
ILE A  92
PHE A 124
LEU A 272
ASP A 276
 BME  A1592 ( 4.0A)
None
None
None
None
 0.85A 2qb4A-2j5cA:
undetectable		 2qb4A-2j5cA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		5 / 11 ARG A 325
ILE A  92
PHE A 124
LEU A 272
ASP A 276
 BME  A1592 ( 4.0A)
None
None
None
None
 0.87A 2qeiA-2j5cA:
undetectable		 2qeiA-2j5cA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		5 / 11 ARG A 325
ILE A  92
PHE A 124
LEU A 272
ASP A 276
 BME  A1592 ( 4.0A)
None
None
None
None
 0.89A 2qjuA-2j5cA:
undetectable		 2qjuA-2j5cA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		3 / 3 ARG A 526
GLU A 523
SER A 198
 None
 0.85A 2xctD-2j5cA:
undetectable		 2xctD-2j5cA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		3 / 3 ASP A 400
THR A 335
GLU A 330
 None
 0.69A 2zifB-2j5cA:
undetectable		 2zifB-2j5cA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		3 / 3 TYR A 315
GLU A 330
ASP A 400
 None
 0.66A 3bxoA-2j5cA:
undetectable		 3bxoA-2j5cA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		3 / 3 TYR A 315
GLU A 330
ASP A 400
 None
 0.61A 3bxoB-2j5cA:
undetectable		 3bxoB-2j5cA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		5 / 12 ILE A 477
ASP A 476
ALA A 480
THR A 483
ILE A 484
 None
 1.18A 3ddyA-2j5cA:
undetectable		 3ddyA-2j5cA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		5 / 12 ASP A 345
ILE A 344
PRO A 450
LEU A 416
TYR A 329
 None
 1.05A 3eeoA-2j5cA:
undetectable		 3eeoA-2j5cA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		3 / 3 LYS A 181
PRO A 182
SER A 183
 None
 0.35A 4k50I-2j5cA:
0.6		 4k50I-2j5cA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		5 / 11 HIS A 454
TRP A 367
ASN A 388
ILE A 337
ALA A 339
 None
None
None
None
BME  A1593 ( 4.8A)
 1.47A 4m83B-2j5cA:
undetectable		 4m83B-2j5cA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		4 / 7 ILE A  92
PHE A 124
LEU A 272
ASP A 276
 None
 0.81A 4mmcA-2j5cA:
undetectable		 4mmcA-2j5cA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		4 / 6 LEU A 115
ILE A 112
LEU A  99
GLU A 127
 None
 0.94A 4w5nA-2j5cA:
undetectable		 4w5nA-2j5cA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		5 / 9 GLN A 193
LEU A 192
LEU A 219
ALA A 151
ALA A 215
 None
 1.02A 5g44A-2j5cA:
undetectable		 5g44A-2j5cA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		3 / 3 LEU A 585
THR A 335
ASN A 338
 None
 0.72A 6baaE-2j5cA:
undetectable		 6baaE-2j5cA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		3 / 3 LEU A 585
THR A 335
ASN A 338
 None
 0.73A 6baaF-2j5cA:
undetectable		 6baaF-2j5cA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		3 / 3 LEU A 585
THR A 335
ASN A 338
 None
 0.73A 6baaG-2j5cA:
0.6		 6baaG-2j5cA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2j5c 1,8-CINEOLE SYNTHASE
(Salvia
fruticosa) 		3 / 3 LEU A 585
THR A 335
ASN A 338
 None
 0.73A 6baaH-2j5cA:
undetectable		 6baaH-2j5cA:
16.47