SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j5g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 10 LEU D 103
LEU D 104
ARG D 221
ILE D 236
HIS D 156
 None
 1.38A 1a52A-2j5gD:
undetectable		 1a52A-2j5gD:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 10 LEU D 103
LEU D 104
ARG D 221
ILE D 236
HIS D 156
 None
 1.40A 1a52B-2j5gD:
undetectable		 1a52B-2j5gD:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU D 103
LEU D 104
ARG D 221
ILE D 236
GLY D  96
 None
 1.03A 1g50B-2j5gD:
undetectable		 1g50B-2j5gD:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU D 158
LEU D 103
LEU D 104
ILE D 236
GLY D  96
 None
 1.07A 1g50B-2j5gD:
undetectable		 1g50B-2j5gD:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 11 LEU D 103
LEU D 104
ARG D 221
ILE D 236
GLY D  96
 None
 1.03A 1g50C-2j5gD:
undetectable		 1g50C-2j5gD:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 11 LEU D 158
LEU D 103
LEU D 104
ILE D 236
GLY D  96
 None
 1.08A 1g50C-2j5gD:
undetectable		 1g50C-2j5gD:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 8 GLY D  96
LEU D 240
VAL D 155
PHE D  38
 None
 1.00A 1gsfC-2j5gD:
undetectable		 1gsfC-2j5gD:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 10 LEU D 158
LEU D 103
LEU D 104
ARG D 221
ILE D 236
 None
 1.02A 1pcgA-2j5gD:
undetectable		 1pcgA-2j5gD:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKT_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 10 LEU D 158
LEU D 103
LEU D 104
ARG D 221
HIS D 156
 None
 1.42A 1qktA-2j5gD:
undetectable		 1qktA-2j5gD:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 LEU D 240
HIS D 144
ILE D 149
 None
 0.69A 1s9pB-2j5gD:
undetectable		 1s9pB-2j5gD:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU D 103
LEU D 104
ARG D 221
ILE D 236
GLY D  96
 None
 1.02A 2j7xA-2j5gD:
undetectable		 2j7xA-2j5gD:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 6 LEU D 100
TRP D  71
MET D  72
LEU D 120
 None
 1.40A 2oz7A-2j5gD:
undetectable		 2oz7A-2j5gD:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 8 ASP D 153
ASP D 141
LEU D 172
HIS D 144
 None
 1.11A 2q0iA-2j5gD:
undetectable		 2q0iA-2j5gD:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU D 103
LEU D 104
ARG D 221
ILE D 236
GLY D  96
 None
 0.98A 2yjaB-2j5gD:
undetectable		 2yjaB-2j5gD:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 ASP D  69
THR D  39
GLU D  74
 None
 0.74A 2zifB-2j5gD:
undetectable		 2zifB-2j5gD:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 GLY D 152
GLY D 235
GLY D 239
 None
 0.38A 3bogC-2j5gD:
undetectable		 3bogC-2j5gD:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 5 LEU D 100
THR D 127
GLU D 123
HIS D  43
 None
 1.49A 3n58C-2j5gD:
undetectable		 3n58C-2j5gD:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU D 103
LEU D 104
ARG D 221
ILE D 236
GLY D  96
 None
 1.03A 3q95A-2j5gD:
undetectable		 3q95A-2j5gD:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU D 158
LEU D 103
LEU D 104
ARG D 221
ILE D 236
 None
 1.05A 3q95A-2j5gD:
undetectable		 3q95A-2j5gD:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 6 ALA D 202
ILE D 111
LEU D 132
GLU D  26
 None
 0.89A 3r9sC-2j5gD:
23.3		 3r9sC-2j5gD:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 5 LEU D 240
HIS D 156
HIS D 121
GLU D 123
 None
 1.36A 4a7bB-2j5gD:
undetectable		 4a7bB-2j5gD:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 4 ASN D  14
SER D 112
LEU D  64
THR D  31
 None
 1.15A 4an2A-2j5gD:
undetectable		 4an2A-2j5gD:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		6 / 12 LEU D 103
LEU D 104
ARG D 221
ILE D 157
ILE D 236
HIS D 156
 None
 1.44A 4j24A-2j5gD:
undetectable		 4j24A-2j5gD:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		6 / 12 LEU D 158
LEU D 103
LEU D 104
ARG D 221
ILE D 236
HIS D 156
 None
 1.42A 4j24A-2j5gD:
undetectable		 4j24A-2j5gD:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		6 / 12 LEU D 103
LEU D 104
ARG D 221
ILE D 157
ILE D 236
HIS D 156
 None
 1.44A 4j24C-2j5gD:
undetectable		 4j24C-2j5gD:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU D 103
LEU D 104
ARG D 221
ILE D 236
GLY D  96
 None
 1.09A 4j26A-2j5gD:
undetectable		 4j26A-2j5gD:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU D 103
LEU D 104
ARG D 221
ILE D 157
ILE D 236
 None
 1.08A 4j26B-2j5gD:
undetectable		 4j26B-2j5gD:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 10 ALA D 180
THR D 179
ALA D 183
VAL D 192
GLY D 116
 None
 1.00A 4qvyK-2j5gD:
undetectable
4qvyL-2j5gD:
undetectable		 4qvyK-2j5gD:
22.42
4qvyL-2j5gD:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 10 ALA D 180
THR D 179
ALA D 183
VAL D 192
GLY D 116
 None
 1.00A 4qvyY-2j5gD:
undetectable
4qvyZ-2j5gD:
undetectable		 4qvyY-2j5gD:
22.42
4qvyZ-2j5gD:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU D 103
LEU D 104
ARG D 221
ILE D 236
GLY D  96
 None
 0.97A 4xi3B-2j5gD:
undetectable		 4xi3B-2j5gD:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 11 LEU D 103
LEU D 104
ARG D 221
ILE D 236
GLY D  96
 None
 1.00A 5dxbB-2j5gD:
undetectable		 5dxbB-2j5gD:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU D 103
LEU D 104
ARG D 221
ILE D 236
GLY D  96
 None
 0.90A 5gtrA-2j5gD:
undetectable		 5gtrA-2j5gD:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 10 GLY D 239
GLY D 152
LEU D 240
LEU D 100
GLU D 123
 None
 1.33A 5hwkA-2j5gD:
undetectable		 5hwkA-2j5gD:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 10 GLY D 239
GLY D 152
LEU D 240
LEU D 100
GLU D 123
 None
 1.33A 5hwkB-2j5gD:
undetectable		 5hwkB-2j5gD:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 2j5g ALR4455 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 6 LEU D  36
THR D  31
GLY D  33
ARG D  28
 None
 1.27A 6gtqB-2j5gD:
undetectable
6gtqD-2j5gD:
undetectable		 6gtqB-2j5gD:
21.64
6gtqD-2j5gD:
12.16