SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 2j5t GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 7 LEU A   7
VAL A 245
MET A 246
LEU A 254
 None
 0.97A 1hk3A-2j5tA:
undetectable		 1hk3A-2j5tA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2j5t GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 7 LEU A 166
ILE A 188
THR A 253
MET A 214
 None
 0.97A 1kglA-2j5tA:
undetectable		 1kglA-2j5tA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2j5t GLUTAMATE 5-KINASE
(Escherichia
coli) 		5 / 12 MET A 214
LEU A 174
ILE A 194
PHE A 255
ILE A 233
 None
 1.14A 1xotA-2j5tA:
undetectable		 1xotA-2j5tA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2j5t GLUTAMATE 5-KINASE
(Escherichia
coli) 		5 / 12 VAL A 359
ILE A 288
THR A 366
LEU A 289
VAL A 280
 None
 0.98A 2jn3A-2j5tA:
undetectable		 2jn3A-2j5tA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2j5t GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 8 GLY A 161
ALA A 162
ASP A 163
VAL A  48
 None
 0.52A 3em6A-2j5tA:
undetectable		 3em6A-2j5tA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 2j5t GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 6 GLY A 243
GLN A  34
ILE A 249
VAL A 245
 None
 1.15A 3kvvA-2j5tA:
undetectable		 3kvvA-2j5tA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 2j5t GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 6 GLY A 243
GLN A  34
ILE A 249
VAL A 245
 None
 1.12A 3kvvB-2j5tA:
undetectable		 3kvvB-2j5tA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 2j5t GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 6 GLY A 243
GLN A  34
ILE A 249
VAL A 245
 None
 1.12A 3kvvC-2j5tA:
undetectable		 3kvvC-2j5tA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 2j5t GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 6 GLY A 243
GLN A  34
ILE A 249
VAL A 245
 None
 1.13A 3kvvF-2j5tA:
2.1		 3kvvF-2j5tA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 2j5t GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 7 ARG A  82
GLY A  56
GLU A  58
GLN A  80
 None
 1.10A 4g0vA-2j5tA:
undetectable		 4g0vA-2j5tA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2j5t GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 7 ALA A 140
THR A 141
ALA A 142
THR A 104
 None
 1.02A 4qw0K-2j5tA:
undetectable		 4qw0K-2j5tA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2j5t GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 7 ALA A 140
THR A 141
ALA A 142
THR A 104
 None
 1.02A 4qw0Y-2j5tA:
undetectable		 4qw0Y-2j5tA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2j5t GLUTAMATE 5-KINASE
(Escherichia
coli) 		5 / 12 LEU A 155
LEU A 121
ALA A 162
VAL A   8
ILE A 229
 None
 1.11A 4x1kD-2j5tA:
undetectable		 4x1kD-2j5tA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 2j5t GLUTAMATE 5-KINASE
(Escherichia
coli) 		5 / 9 ALA A  55
LEU A  90
LEU A  23
ASN A  24
LEU A  86
 None
 1.45A 4x30A-2j5tA:
undetectable		 4x30A-2j5tA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2j5t GLUTAMATE 5-KINASE
(Escherichia
coli) 		5 / 9 ILE A  45
THR A  49
TRP A  87
LEU A  31
LEU A  16
 None
 1.42A 5fhzB-2j5tA:
3.7		 5fhzB-2j5tA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2j5t GLUTAMATE 5-KINASE
(Escherichia
coli) 		4 / 8 LEU A 166
ILE A 188
THR A 253
MET A 214
 None
 0.89A 5ljbA-2j5tA:
undetectable		 5ljbA-2j5tA:
17.22