SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2j5u MREC PROTEIN
(Listeria
monocytogenes) 		4 / 7 PHE A 194
LEU A 209
ALA A 256
VAL A 245
 None
 0.83A 1epbA-2j5uA:
undetectable		 1epbA-2j5uA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2j5u MREC PROTEIN
(Listeria
monocytogenes) 		4 / 8 PHE A 194
LEU A 209
ALA A 256
VAL A 245
 None
 0.76A 1epbB-2j5uA:
undetectable		 1epbB-2j5uA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 2j5u MREC PROTEIN
(Listeria
monocytogenes) 		3 / 3 LYS A 160
ARG A 182
VAL A 183
 None
 0.99A 2r2vC-2j5uA:
undetectable
2r2vD-2j5uA:
undetectable		 2r2vC-2j5uA:
11.45
2r2vD-2j5uA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 2j5u MREC PROTEIN
(Listeria
monocytogenes) 		4 / 8 LEU A  96
LYS A  97
ASN A 100
LEU A 103
 None
 0.59A 2xn3A-2j5uA:
undetectable
2xn3B-2j5uA:
undetectable		 2xn3A-2j5uA:
21.71
2xn3B-2j5uA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2j5u MREC PROTEIN
(Listeria
monocytogenes) 		4 / 8 LEU A 173
THR A 152
VAL A 270
ALA A 262
 None
 1.01A 3ax9A-2j5uA:
undetectable		 3ax9A-2j5uA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2j5u MREC PROTEIN
(Listeria
monocytogenes) 		4 / 7 LEU A 207
ALA A 185
GLY A 236
ILE A 237
 None
 0.88A 3spkB-2j5uA:
1.1		 3spkB-2j5uA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 2j5u MREC PROTEIN
(Listeria
monocytogenes) 		5 / 11 ILE A 258
ILE A 242
GLY A 221
GLN A 188
GLY A 189
 None
 1.11A 4ac9B-2j5uA:
2.6
4ac9C-2j5uA:
2.6		 4ac9B-2j5uA:
20.53
4ac9C-2j5uA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2j5u MREC PROTEIN
(Listeria
monocytogenes) 		4 / 8 ILE A 258
GLY A 240
VAL A 245
GLN A 222
 None
 0.90A 4acbB-2j5uA:
3.4
4acbC-2j5uA:
2.6		 4acbB-2j5uA:
20.53
4acbC-2j5uA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 2j5u MREC PROTEIN
(Listeria
monocytogenes) 		4 / 4 VAL A 171
ALA A 150
ILE A 158
THR A 152
 None
 1.18A 5e4dB-2j5uA:
undetectable		 5e4dB-2j5uA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2j5u MREC PROTEIN
(Listeria
monocytogenes) 		4 / 6 PHE A 233
PRO A 234
THR A 152
ILE A 237
 None
 1.17A 5ih0A-2j5uA:
undetectable		 5ih0A-2j5uA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2j5u MREC PROTEIN
(Listeria
monocytogenes) 		5 / 11 GLU A 172
GLY A 159
SER A 122
VAL A 135
ALA A 169
 None
 1.10A 5o96A-2j5uA:
undetectable
5o96B-2j5uA:
undetectable		 5o96A-2j5uA:
21.69
5o96B-2j5uA:
21.69