SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 2j63 AP-ENDONUCLEASE
(Leishmania
major) 		3 / 3 TRP A 308
ARG A 299
THR A 307
 None
 0.79A 1df7A-2j63A:
undetectable		 1df7A-2j63A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 2j63 AP-ENDONUCLEASE
(Leishmania
major) 		4 / 7 ARG A 398
ASN A 337
TYR A 200
ARG A 286
 None
 1.43A 1f9gA-2j63A:
undetectable		 1f9gA-2j63A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2j63 AP-ENDONUCLEASE
(Leishmania
major) 		4 / 7 THR A 221
VAL A 252
THR A 254
VAL A 273
 None
 0.41A 3em0B-2j63A:
undetectable		 3em0B-2j63A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 2j63 AP-ENDONUCLEASE
(Leishmania
major) 		4 / 6 PHE A 115
ASP A 425
TYR A 385
PRO A 430
 None
 1.46A 3jqaA-2j63A:
2.2		 3jqaA-2j63A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 2j63 AP-ENDONUCLEASE
(Leishmania
major) 		4 / 6 PHE A 115
ASP A 425
TYR A 385
PRO A 430
 None
 1.36A 3jqaB-2j63A:
2.1		 3jqaB-2j63A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 2j63 AP-ENDONUCLEASE
(Leishmania
major) 		3 / 3 PHE A 440
TYR A 392
LEU A 165
 None
 0.71A 3keeB-2j63A:
undetectable		 3keeB-2j63A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2j63 AP-ENDONUCLEASE
(Leishmania
major) 		3 / 3 PHE A 440
TYR A 392
LEU A 165
 None
 0.73A 3sueB-2j63A:
undetectable		 3sueB-2j63A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2j63 AP-ENDONUCLEASE
(Leishmania
major) 		5 / 9 LEU A 144
LYS A 145
VAL A 137
GLY A 139
LEU A 151
 None
 1.35A 4b3oA-2j63A:
undetectable		 4b3oA-2j63A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 2j63 AP-ENDONUCLEASE
(Leishmania
major) 		4 / 5 PHE A 381
ASP A 411
PHE A 440
VAL A 391
 None
 1.19A 5a1rA-2j63A:
undetectable		 5a1rA-2j63A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2j63 AP-ENDONUCLEASE
(Leishmania
major) 		4 / 6 PHE A 330
PHE A 427
SER A 377
VAL A 378
 None
 1.20A 5hesA-2j63A:
undetectable		 5hesA-2j63A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 2j63 AP-ENDONUCLEASE
(Leishmania
major) 		4 / 5 THR A 310
HIS A 328
ALA A 309
ASP A 306
 None
 1.35A 5mfxA-2j63A:
undetectable		 5mfxA-2j63A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2j63 AP-ENDONUCLEASE
(Leishmania
major) 		5 / 12 GLY A 186
LEU A 163
LEU A 165
LEU A 151
MET A 155
 None
 0.99A 5nfjA-2j63A:
undetectable		 5nfjA-2j63A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 2j63 AP-ENDONUCLEASE
(Leishmania
major) 		4 / 7 ASP A 191
ASN A 178
ALA A 175
LEU A 181
 None
 0.98A 6ci6A-2j63A:
undetectable		 6ci6A-2j63A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 2j63 AP-ENDONUCLEASE
(Leishmania
major) 		4 / 6 ASP A 411
ASN A 274
LEU A 163
PHE A 154
 None
 1.03A 6ekuA-2j63A:
undetectable		 6ekuA-2j63A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 2j63 AP-ENDONUCLEASE
(Leishmania
major) 		4 / 6 ARG A 418
SER A 416
ALA A 271
ALA A 313
 None
 1.19A 6ma6A-2j63A:
undetectable		 6ma6A-2j63A:
9.93