SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 2j66 BTRK
(Bacillus
circulans) 		4 / 6 HIS A 383
ASP A 411
ASP A 410
PRO A 388
 None
 1.32A 1ilqA-2j66A:
undetectable
1ilqC-2j66A:
undetectable		 1ilqA-2j66A:
12.46
1ilqC-2j66A:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2j66 BTRK
(Bacillus
circulans) 		4 / 7 PHE A 145
ILE A 139
PRO A 141
GLU A 163
 None
 1.03A 1oniA-2j66A:
undetectable
1oniB-2j66A:
undetectable		 1oniA-2j66A:
16.46
1oniB-2j66A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2j66 BTRK
(Bacillus
circulans) 		4 / 5 PHE A 145
ILE A 139
PRO A 141
GLU A 163
 None
 1.10A 1oniG-2j66A:
1.7
1oniH-2j66A:
undetectable		 1oniG-2j66A:
16.46
1oniH-2j66A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2j66 BTRK
(Bacillus
circulans) 		4 / 7 ILE A 139
PRO A 141
GLU A 163
PHE A 145
 None
 1.01A 1oniG-2j66A:
undetectable
1oniI-2j66A:
undetectable		 1oniG-2j66A:
16.46
1oniI-2j66A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 2j66 BTRK
(Bacillus
circulans) 		5 / 12 THR A 205
LEU A 208
ILE A 184
PHE A 261
TYR A 216
 None
 1.22A 1wsvA-2j66A:
undetectable		 1wsvA-2j66A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 2j66 BTRK
(Bacillus
circulans) 		4 / 6 LEU A  34
TYR A 273
ILE A 268
GLY A 230
 None
 0.95A 2du8B-2j66A:
undetectable		 2du8B-2j66A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 2j66 BTRK
(Bacillus
circulans) 		5 / 9 GLY A 243
ILE A 198
THR A 205
VAL A 249
ILE A  42
 None
EDO  A1418 (-3.9A)
None
None
None
 1.29A 2nnhB-2j66A:
undetectable		 2nnhB-2j66A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2j66 BTRK
(Bacillus
circulans) 		4 / 8 PHE A 229
THR A 195
VAL A 249
THR A 248
 None
 0.72A 2qbmA-2j66A:
undetectable		 2qbmA-2j66A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 2j66 BTRK
(Bacillus
circulans) 		3 / 3 LEU A 377
ASN A  53
ARG A 404
 None
 0.93A 2qhfA-2j66A:
undetectable		 2qhfA-2j66A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 2j66 BTRK
(Bacillus
circulans) 		3 / 3 ARG A 134
GLU A  86
TYR A  45
 None
 0.90A 3k37B-2j66A:
undetectable		 3k37B-2j66A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2j66 BTRK
(Bacillus
circulans) 		5 / 12 HIS A  80
TYR A  22
ILE A  54
ALA A  57
LEU A  46
 None
 1.21A 3n8xA-2j66A:
undetectable		 3n8xA-2j66A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2j66 BTRK
(Bacillus
circulans) 		5 / 12 GLY A  92
ALA A  70
PHE A  90
ALA A  72
SER A  98
 None
 1.12A 3sudB-2j66A:
undetectable		 3sudB-2j66A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2j66 BTRK
(Bacillus
circulans) 		4 / 5 ASP A  23
LEU A  21
GLU A   7
LYS A 395
 None
 1.42A 4a3pA-2j66A:
undetectable		 4a3pA-2j66A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2j66 BTRK
(Bacillus
circulans) 		4 / 8 LEU A  65
TYR A  45
ILE A 267
THR A  38
 None
 0.84A 4ma7A-2j66A:
undetectable		 4ma7A-2j66A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2j66 BTRK
(Bacillus
circulans) 		5 / 11 ALA A 103
GLY A 107
LEU A 176
LEU A 119
THR A 179
 None
 1.14A 4zmeA-2j66A:
undetectable		 4zmeA-2j66A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2j66 BTRK
(Bacillus
circulans) 		4 / 8 ILE A 245
LEU A 240
ILE A 198
SER A  47
 None
None
EDO  A1418 (-3.9A)
PLP  A1419 (-3.2A)
 0.70A 5numA-2j66A:
undetectable		 5numA-2j66A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2j66 BTRK
(Bacillus
circulans) 		4 / 6 LEU A 286
PRO A 344
HIS A 304
HIS A 305
 None
 1.08A 6pahA-2j66A:
undetectable		 6pahA-2j66A:
22.08