SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j6h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 GLY A 471
LEU A 480
ALA A 479
TYR A 476
 None
 0.84A 1dmaA-2j6hA:
undetectable		 1dmaA-2j6hA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 11 ALA A 285
LEU A 289
LEU A 281
LEU A 389
ILE A 344
 None
 0.90A 1ha2A-2j6hA:
2.7		 1ha2A-2j6hA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 ARG A  22
ALA A   6
GLY A 183
ILE A  15
 None
 0.55A 1hshD-2j6hA:
undetectable		 1hshD-2j6hA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 6 TRP A 133
LEU A 111
LEU A 107
PRO A 106
 None
 1.27A 1hz4A-2j6hA:
undetectable		 1hz4A-2j6hA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 ASP A 323
PHE A 330
VAL A 337
 None
 0.61A 1kijB-2j6hA:
1.7		 1kijB-2j6hA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A 601
GLU A 488
LEU A 484
GLU A 481
 None
G6Q  A1610 (-2.5A)
None
None
 1.03A 1linA-2j6hA:
undetectable		 1linA-2j6hA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 ASP A 210
LEU A 146
ALA A 172
LEU A 206
 None
 1.12A 1nh8A-2j6hA:
2.4		 1nh8A-2j6hA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE A 561
PHE A 546
ALA A 547
PHE A 553
LEU A 543
 None
 1.21A 1og5B-2j6hA:
undetectable		 1og5B-2j6hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 152
LEU A 146
VAL A 145
LEU A 178
LEU A 206
 None
 1.10A 1s19A-2j6hA:
undetectable		 1s19A-2j6hA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 6 LEU A 346
GLY A 307
SER A 310
ILE A 295
 None
 0.88A 1yajF-2j6hA:
undetectable		 1yajF-2j6hA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 409
VAL A 416
ILE A 344
ILE A 297
ALA A 299
 None
 1.18A 2gj5A-2j6hA:
undetectable		 2gj5A-2j6hA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O02_A_BEZA801_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.92A 2o02A-2j6hA:
0.0		 2o02A-2j6hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 LEU A  23
ILE A   3
HIS A  71
GLY A  99
 None
None
None
ONL  A1609 (-3.5A)
 0.95A 3b9lA-2j6hA:
2.2		 3b9lA-2j6hA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 LEU A 130
ASP A 162
VAL A  95
THR A 158
 None
 1.28A 3cyxB-2j6hA:
undetectable		 3cyxB-2j6hA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 8 GLY A 552
ALA A 551
ASP A 550
ASP A 548
VAL A 518
 None
 1.20A 3em6A-2j6hA:
undetectable		 3em6A-2j6hA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.06A 3fhjA-2j6hA:
undetectable		 3fhjA-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.05A 3fhjB-2j6hA:
undetectable		 3fhjB-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.05A 3fhjC-2j6hA:
undetectable		 3fhjC-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.06A 3fhjD-2j6hA:
undetectable		 3fhjD-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.05A 3fhjE-2j6hA:
undetectable		 3fhjE-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.06A 3fhjF-2j6hA:
undetectable		 3fhjF-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.09A 3fi0A-2j6hA:
undetectable		 3fi0A-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.06A 3fi0C-2j6hA:
undetectable		 3fi0C-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.07A 3fi0D-2j6hA:
undetectable		 3fi0D-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.08A 3fi0F-2j6hA:
undetectable		 3fi0F-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.04A 3fi0H-2j6hA:
undetectable		 3fi0H-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 8 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.06A 3fi0I-2j6hA:
undetectable		 3fi0I-2j6hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.07A 3fi0J-2j6hA:
undetectable		 3fi0J-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.07A 3fi0K-2j6hA:
undetectable		 3fi0K-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.10A 3fi0L-2j6hA:
undetectable		 3fi0L-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.11A 3fi0M-2j6hA:
undetectable		 3fi0M-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.07A 3fi0N-2j6hA:
undetectable		 3fi0N-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.10A 3fi0O-2j6hA:
undetectable		 3fi0O-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.04A 3fi0R-2j6hA:
undetectable		 3fi0R-2j6hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 LEU A 507
PRO A 506
LEU A 502
ARG A 472
 None
 1.40A 3hcoA-2j6hA:
3.2		 3hcoA-2j6hA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 SER A 604
ARG A  26
ARG A 173
GLU A 208
 G6Q  A1610 ( 4.9A)
None
None
None
 1.25A 3k9fA-2j6hA:
undetectable
3k9fB-2j6hA:
undetectable
3k9fC-2j6hA:
3.4		 3k9fA-2j6hA:
22.17
3k9fB-2j6hA:
22.17
3k9fC-2j6hA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 6 VAL A 536
LEU A 583
ILE A 478
LEU A 543
 None
 0.91A 3kk6A-2j6hA:
2.3		 3kk6A-2j6hA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 MET A 161
LEU A  63
ALA A  34
LEU A  45
VAL A  96
 None
 1.50A 3ozkA-2j6hA:
undetectable		 3ozkA-2j6hA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 ASN A 532
GLY A 500
ALA A 499
GLY A 473
 None
 0.58A 3so9A-2j6hA:
undetectable		 3so9A-2j6hA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 THR A 122
GLY A  78
PRO A  80
ASN A  84
 ONL  A1609 ( 4.7A)
None
None
None
 1.02A 3u8qA-2j6hA:
undetectable		 3u8qA-2j6hA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 11 VAL A  35
ALA A  13
LEU A  63
LEU A  17
GLY A  32
 None
 1.11A 3zosA-2j6hA:
undetectable
3zosB-2j6hA:
undetectable		 3zosA-2j6hA:
19.41
3zosB-2j6hA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 GLU A 396
GLN A 408
SER A 303
LEU A 346
LEU A 356
 None
None
G6Q  A1610 (-2.6A)
None
None
 1.46A 4k38A-2j6hA:
undetectable
4k38D-2j6hA:
undetectable		 4k38A-2j6hA:
20.42
4k38D-2j6hA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 11 SER A 362
LEU A 342
GLY A 369
ILE A 433
LEU A 437
 None
 1.02A 4kt0A-2j6hA:
undetectable
4kt0J-2j6hA:
undetectable		 4kt0A-2j6hA:
21.81
4kt0J-2j6hA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 LEU A 389
VAL A 411
LEU A 288
LEU A 289
 None
 0.89A 4l1xA-2j6hA:
undetectable		 4l1xA-2j6hA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A 448
THR A 406
ALA A 262
ILE A 263
 None
 0.76A 4ubsA-2j6hA:
undetectable		 4ubsA-2j6hA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 THR A 124
GLY A 157
SER A 176
ALA A 353
THR A 352
 ONL  A1609 (-4.3A)
None
None
None
G6Q  A1610 (-3.1A)
 1.16A 4uckB-2j6hA:
undetectable		 4uckB-2j6hA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 371
LEU A 342
ILE A 344
LEU A 346
ILE A 297
 None
 0.82A 4y0rA-2j6hA:
undetectable		 4y0rA-2j6hA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		6 / 12 LEU A 389
LEU A 371
ILE A 373
GLU A 481
ILE A 297
LEU A 278
 None
 1.05A 4y0sA-2j6hA:
undetectable		 4y0sA-2j6hA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 6 TYR A 156
GLY A 175
GLU A 208
ARG A 173
 None
 1.16A 4zbqA-2j6hA:
undetectable		 4zbqA-2j6hA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.89A 5ewzA-2j6hA:
0.0		 5ewzA-2j6hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 MET A 447
GLN A 446
ARG A 443
 None
 0.82A 5ewzB-2j6hA:
2.3		 5ewzB-2j6hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EXA_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.95A 5exaA-2j6hA:
0.0		 5exaA-2j6hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EXA_B_BEZB303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.93A 5exaB-2j6hA:
0.0		 5exaB-2j6hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 PRO A 565
LEU A 582
ILE A 454
LEU A 440
 None
 0.98A 5ieoA-2j6hA:
undetectable		 5ieoA-2j6hA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J31_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.87A 5j31B-2j6hA:
0.0		 5j31B-2j6hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.96A 5jm4A-2j6hA:
2.1		 5jm4A-2j6hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.93A 5m35A-2j6hA:
undetectable		 5m35A-2j6hA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 MET A 447
GLN A 446
ARG A 443
 None
 0.88A 5m35B-2j6hA:
2.1		 5m35B-2j6hA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 MET A 447
GLN A 446
ARG A 443
 None
 0.92A 5m36A-2j6hA:
undetectable		 5m36A-2j6hA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.91A 5m36B-2j6hA:
0.0		 5m36B-2j6hA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M37_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.90A 5m37A-2j6hA:
0.0		 5m37A-2j6hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M37_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.93A 5m37B-2j6hA:
0.0		 5m37B-2j6hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 GLU A 481
ALA A 404
SER A 401
GLY A 307
LEU A 346
 None
None
G6Q  A1610 (-4.1A)
None
None
 1.20A 5m5cB-2j6hA:
3.9		 5m5cB-2j6hA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 GLU A 481
ALA A 404
SER A 401
GLY A 307
LEU A 346
 None
None
G6Q  A1610 (-4.1A)
None
None
 1.23A 5m5cE-2j6hA:
4.4		 5m5cE-2j6hA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 SER A 362
LEU A 342
GLY A 369
ILE A 433
LEU A 437
 None
 1.00A 5oy01-2j6hA:
undetectable
5oy07-2j6hA:
undetectable		 5oy01-2j6hA:
8.61
5oy07-2j6hA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 6 LEU A 415
VAL A 411
THR A 407
LEU A 371
LEU A 298
 None
 1.24A 5tudD-2j6hA:
1.8		 5tudD-2j6hA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 7 VAL A 376
ARG A  26
TYR A  25
GLU A 351
 None
 0.90A 5umwB-2j6hA:
undetectable
5umwE-2j6hA:
undetectable		 5umwB-2j6hA:
10.82
5umwE-2j6hA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 6 HIS A 250
TYR A 585
GLU A 255
GLN A 253
 None
 1.30A 6d8pA-2j6hA:
0.0		 6d8pA-2j6hA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 MET A 447
GLN A 446
ARG A 443
 None
 0.95A 6fn9A-2j6hA:
2.1		 6fn9A-2j6hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.94A 6fnaA-2j6hA:
0.0		 6fnaA-2j6hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 MET A 447
GLN A 446
ARG A 443
 None
 0.94A 6fnaB-2j6hA:
undetectable		 6fnaB-2j6hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 MET A 447
GLN A 446
ARG A 443
 None
 0.93A 6fnbA-2j6hA:
2.1		 6fnbA-2j6hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.94A 6fnbB-2j6hA:
0.0		 6fnbB-2j6hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNC_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.93A 6fncA-2j6hA:
0.0		 6fncA-2j6hA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNC_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.93A 6fncB-2j6hA:
0.0		 6fncB-2j6hA:
17.60