SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j6i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
4 / 8 ALA A 209
LEU A 199
LEU A 180
ALA A 172
None
0.75A 1e7cA-2j6iA:
undetectable
1e7cA-2j6iA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
4 / 8 LEU A  20
SER A 313
GLN A 287
THR A 309
None
1.13A 1ig3A-2j6iA:
2.6
1ig3B-2j6iA:
2.8
1ig3A-2j6iA:
20.95
1ig3B-2j6iA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
3 / 3 ASP A  99
ASP A  80
ASN A 104
None
0.63A 2bm9D-2j6iA:
5.2
2bm9D-2j6iA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 11 ASN A 255
VAL A 283
ASP A 282
ILE A 175
ARG A 258
None
1.26A 2f9wA-2j6iA:
undetectable
2f9wB-2j6iA:
undetectable
2f9wA-2j6iA:
21.53
2f9wB-2j6iA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 ILE A  42
ILE A   3
ALA A  72
LEU A  85
ILE A  74
None
0.99A 2h79A-2j6iA:
undetectable
2h79A-2j6iA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 11 GLY A  92
THR A  66
ILE A  65
LEU A  28
THR A 327
None
1.22A 3bexC-2j6iA:
undetectable
3bexD-2j6iA:
undetectable
3bexC-2j6iA:
20.32
3bexD-2j6iA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 10 LEU A  28
THR A 327
GLY A  92
THR A  66
ILE A  65
None
1.23A 3bexC-2j6iA:
undetectable
3bexD-2j6iA:
undetectable
3bexC-2j6iA:
20.32
3bexD-2j6iA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 10 GLY A  92
THR A  66
ILE A  65
LEU A  28
THR A 327
None
1.21A 3bexE-2j6iA:
undetectable
3bexF-2j6iA:
undetectable
3bexE-2j6iA:
20.32
3bexF-2j6iA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 11 LEU A  28
THR A 327
GLY A  92
THR A  66
ILE A  65
None
1.21A 3bexE-2j6iA:
undetectable
3bexF-2j6iA:
undetectable
3bexE-2j6iA:
20.32
3bexF-2j6iA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 11 GLY A  92
THR A  66
ILE A  65
LEU A  28
THR A 327
None
1.22A 3bf1A-2j6iA:
undetectable
3bf1B-2j6iA:
undetectable
3bf1A-2j6iA:
20.32
3bf1B-2j6iA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 LEU A  28
THR A 327
GLY A  92
THR A  66
ILE A  65
None
1.21A 3bf1A-2j6iA:
undetectable
3bf1B-2j6iA:
undetectable
3bf1A-2j6iA:
20.32
3bf1B-2j6iA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 11 GLY A  92
THR A  66
ILE A  65
LEU A  28
THR A 327
None
1.23A 3bf1C-2j6iA:
undetectable
3bf1D-2j6iA:
undetectable
3bf1C-2j6iA:
20.32
3bf1D-2j6iA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 11 LEU A  28
THR A 327
GLY A  92
THR A  66
ILE A  65
None
1.25A 3bf1C-2j6iA:
undetectable
3bf1D-2j6iA:
undetectable
3bf1C-2j6iA:
20.32
3bf1D-2j6iA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 11 GLY A  92
THR A  66
ILE A  65
LEU A  28
THR A 327
None
1.21A 3bf1E-2j6iA:
undetectable
3bf1F-2j6iA:
undetectable
3bf1E-2j6iA:
20.32
3bf1F-2j6iA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 11 LEU A  28
THR A 327
GLY A  92
THR A  66
ILE A  65
None
1.22A 3bf1E-2j6iA:
undetectable
3bf1F-2j6iA:
undetectable
3bf1E-2j6iA:
20.32
3bf1F-2j6iA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 ILE A  42
ILE A   3
ALA A  72
LEU A  85
ILE A  74
None
0.99A 3gwsX-2j6iA:
undetectable
3gwsX-2j6iA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
4 / 6 ALA A 260
ILE A 261
VAL A 283
ASN A 255
None
1.10A 3nneG-2j6iA:
2.0
3nneG-2j6iA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 11 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
None
1.02A 3pghB-2j6iA:
undetectable
3pghB-2j6iA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
None
1.01A 3pghC-2j6iA:
undetectable
3pghC-2j6iA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
None
1.00A 3pghD-2j6iA:
undetectable
3pghD-2j6iA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 LEU A  41
LEU A   7
CYH A  23
GLN A 320
ILE A  65
None
1.43A 4a79B-2j6iA:
undetectable
4a79B-2j6iA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
3 / 3 ASP A 345
TRP A  33
SER A 118
None
PG4  A1354 (-3.7A)
None
0.99A 4lrhA-2j6iA:
undetectable
4lrhA-2j6iA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 GLY A  92
THR A  66
ILE A  65
LEU A  28
THR A 327
None
1.21A 4o5fA-2j6iA:
undetectable
4o5fB-2j6iA:
undetectable
4o5fA-2j6iA:
22.07
4o5fB-2j6iA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 LEU A  28
THR A 327
GLY A  92
THR A  66
ILE A  65
None
1.26A 4o5fA-2j6iA:
undetectable
4o5fB-2j6iA:
undetectable
4o5fA-2j6iA:
22.07
4o5fB-2j6iA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
None
1.07A 4otyA-2j6iA:
undetectable
4otyA-2j6iA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
None
1.07A 4otyB-2j6iA:
undetectable
4otyB-2j6iA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
None
1.14A 4rrwA-2j6iA:
undetectable
4rrwA-2j6iA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
None
1.15A 4rrwB-2j6iA:
undetectable
4rrwB-2j6iA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
None
1.14A 4rrzA-2j6iA:
undetectable
4rrzA-2j6iA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
None
1.15A 4rrzB-2j6iA:
undetectable
4rrzB-2j6iA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 GLY A  92
THR A  66
ILE A  65
LEU A  28
THR A 327
None
1.27A 5b8hA-2j6iA:
undetectable
5b8hB-2j6iA:
undetectable
5b8hA-2j6iA:
23.02
5b8hB-2j6iA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 LEU A  28
THR A 327
GLY A  92
THR A  66
ILE A  65
None
1.25A 5b8hA-2j6iA:
undetectable
5b8hB-2j6iA:
undetectable
5b8hA-2j6iA:
23.02
5b8hB-2j6iA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 HIS A 232
GLY A 234
LEU A 238
VAL A 179
ASP A 195
None
1.16A 5hg0A-2j6iA:
undetectable
5hg0A-2j6iA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
None
1.07A 5ikqA-2j6iA:
undetectable
5ikqA-2j6iA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
None
1.07A 5ikqB-2j6iA:
undetectable
5ikqB-2j6iA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
None
1.13A 5ikrA-2j6iA:
undetectable
5ikrA-2j6iA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
None
1.08A 5ikrB-2j6iA:
undetectable
5ikrB-2j6iA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 10 PRO A  68
THR A  66
ILE A  65
ILE A  64
ILE A  63
None
1.02A 5murE-2j6iA:
undetectable
5murE-2j6iA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
3 / 3 LEU A 180
THR A 256
ASN A 255
None
0.64A 6baaE-2j6iA:
undetectable
6baaE-2j6iA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
3 / 3 LEU A 180
THR A 256
ASN A 255
None
0.64A 6baaF-2j6iA:
undetectable
6baaF-2j6iA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
3 / 3 LEU A 180
THR A 256
ASN A 255
None
0.65A 6baaG-2j6iA:
undetectable
6baaG-2j6iA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
3 / 3 LEU A 180
THR A 256
ASN A 255
None
0.65A 6baaH-2j6iA:
undetectable
6baaH-2j6iA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii)
5 / 12 GLY A 250
LEU A 132
VAL A 133
ARG A 277
ASP A 158
None
1.19A 6bxmA-2j6iA:
3.2
6bxmA-2j6iA:
21.19