SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j7a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		3 / 3 GLN A 380
TYR A 115
ARG A 116
 None
HEM  A1001 (-4.7A)
None
 0.92A 1gtbA-2j7aA:
undetectable		 1gtbA-2j7aA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		3 / 3 ALA A 386
HIS A 387
VAL A 390
 None
 0.39A 1lqtB-2j7aA:
undetectable		 1lqtB-2j7aA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		3 / 3 ALA A 386
HIS A 387
VAL A 390
 None
 0.41A 1lquB-2j7aA:
undetectable		 1lquB-2j7aA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		4 / 7 GLY A 432
GLU A 428
SER A 430
HIS A 434
 None
None
None
HEM  A1004 (-3.4A)
 1.10A 2ackA-2j7aA:
undetectable		 2ackA-2j7aA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		3 / 3 SER A 333
ASP A 318
CYH A 352
 HEM  A1002 (-2.5A)
HEM  C1004 ( 4.2A)
HEM  A1005 (-2.0A)
 1.15A 2br4E-2j7aA:
undetectable		 2br4E-2j7aA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		4 / 7 TYR A 237
TYR A 265
GLY A 270
ASP A 271
 None
 1.00A 2g70A-2j7aA:
undetectable		 2g70A-2j7aA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		4 / 7 TYR A 237
TYR A 265
GLY A 270
ASP A 271
 None
 0.88A 2g70B-2j7aA:
undetectable		 2g70B-2j7aA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		4 / 6 TYR A 237
TYR A 265
GLY A 270
ASP A 271
 None
 0.95A 2g72A-2j7aA:
undetectable		 2g72A-2j7aA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		4 / 7 TYR A 237
TYR A 265
GLY A 270
ASP A 271
 None
 0.95A 2g72B-2j7aA:
undetectable		 2g72B-2j7aA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		5 / 12 TYR A  64
ASP A  68
ASP A 182
GLU A  47
TYR A  61
 HEM  A1002 (-3.7A)
None
None
None
HEM  A1002 ( 4.4A)
 1.13A 3b7pA-2j7aA:
undetectable		 3b7pA-2j7aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		5 / 12 TYR A  64
ASP A  68
ASP A 182
GLU A  47
TYR A  61
 HEM  A1002 (-3.7A)
None
None
None
HEM  A1002 ( 4.4A)
 1.18A 3b7pB-2j7aA:
undetectable		 3b7pB-2j7aA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		3 / 3 ASN A  83
ASP A 127
GLN A 126
 None
HEM  A1003 (-3.5A)
None
 0.83A 3eeyD-2j7aA:
undetectable		 3eeyD-2j7aA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		5 / 12 ARG A  49
GLU A 157
ALA A  52
GLU A  47
ARG A 199
 None
 1.47A 3k39D-2j7aA:
0.0		 3k39D-2j7aA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		5 / 12 ARG A  49
GLU A 157
ALA A  52
GLU A  47
ARG A 199
 None
 1.47A 3k39N-2j7aA:
undetectable		 3k39N-2j7aA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		5 / 12 ARG A  49
GLU A 157
ALA A  52
GLU A  47
ARG A 199
 None
 1.47A 3k39P-2j7aA:
undetectable		 3k39P-2j7aA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		3 / 3 ALA A 260
ARG A 264
LYS A 268
 None
 0.56A 3kp5B-2j7aA:
undetectable		 3kp5B-2j7aA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_A_ACTA601_0
(CHOLINE OXIDASE)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		4 / 5 ILE A 480
HIS A 497
VAL A 477
ASN A 104
 None
 1.26A 3nneA-2j7aA:
0.0		 3nneA-2j7aA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		4 / 6 ILE A 480
HIS A 497
VAL A 477
ASN A 104
 None
 1.15A 3nneG-2j7aA:
undetectable		 3nneG-2j7aA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA
(Desulfovibrio
vulgaris) 		3 / 3 GLN A  99
ASP A 423
GLN A 419
 None
 0.86A 4aztA-2j7aA:
undetectable		 4aztA-2j7aA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 2j7a CYTOCHROME C QUINOL
DEHYDROGENASE NRFH
(Desulfovibrio
vulgaris) 		3 / 3 ASN C  63
ALA C  62
ARG C  40
 None
 0.78A 5cvtB-2j7aC:
undetectable		 5cvtB-2j7aC:
20.00