SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j7p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		4 / 5 ARG D 124
ALA D 120
ASP D 287
GLY D 285
 None
 1.04A 1e7bA-2j7pD:
undetectable		 1e7bA-2j7pD:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		5 / 9 GLY D 112
GLY D 145
GLY D 146
ASP D 139
ARG D 142
 GNP  D1400 (-3.5A)
None
None
GNP  D1400 ( 4.7A)
GNP  D1400 ( 3.9A)
 1.19A 1mxdA-2j7pD:
3.5		 1mxdA-2j7pD:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		5 / 9 GLY D 112
LYS D 256
GLY D 145
ASP D 139
ARG D 142
 GNP  D1400 (-3.5A)
GNP  D1400 (-3.8A)
None
GNP  D1400 ( 4.7A)
GNP  D1400 ( 3.9A)
 1.18A 1mxdA-2j7pD:
3.5		 1mxdA-2j7pD:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		3 / 3 THR D 118
LEU D 122
LEU D 129
 None
 0.64A 1mz9C-2j7pD:
undetectable		 1mz9C-2j7pD:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		5 / 12 THR D 117
GLY D 114
GLY D 112
VAL D 227
GLY D 283
 GNP  D1400 (-3.6A)
GNP  D1400 (-3.1A)
GNP  D1400 (-3.5A)
None
GNP  D1400 (-3.4A)
 0.91A 1n2xB-2j7pD:
3.6		 1n2xB-2j7pD:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		5 / 8 ASP D 191
GLY D 138
GLY D 146
GLY D 145
LEU D 149
 MG  D1401 ( 4.0A)
None
None
None
None
 1.21A 1qzzA-2j7pD:
3.0		 1qzzA-2j7pD:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		5 / 9 PHE D 292
LEU D 301
GLY D 264
VAL D 270
ILE D 277
 None
 1.32A 2a1oB-2j7pD:
undetectable		 2a1oB-2j7pD:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		4 / 8 ALA D 193
GLY D 163
ALA D 137
CYH D 136
 None
 0.87A 2vh3B-2j7pD:
undetectable		 2vh3B-2j7pD:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		6 / 12 VAL D 252
ILE D 269
GLY D 264
LEU D 301
VAL D 280
ILE D 277
 None
None
None
None
EDO  D1306 ( 4.8A)
None
 1.42A 3em6B-2j7pD:
undetectable		 3em6B-2j7pD:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		5 / 12 GLY D  60
VAL D  56
LEU D  35
VAL D  68
ILE D  22
 None
 1.03A 3frqB-2j7pD:
undetectable		 3frqB-2j7pD:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		4 / 6 GLY D 146
ASP D 168
ASP D 191
GLU D 205
 None
None
MG  D1401 ( 4.0A)
None
 0.87A 3vywC-2j7pD:
3.2		 3vywC-2j7pD:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		5 / 12 GLY D 109
GLY D 194
ASP D 191
LEU D 196
VAL D 113
 None
GNP  D1400 (-3.3A)
MG  D1401 ( 4.0A)
None
GNP  D1400 (-4.1A)
 0.97A 4fr0A-2j7pD:
2.3		 4fr0A-2j7pD:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 2j7p CELL DIVISION
PROTEIN FTSY
(Thermus
aquaticus) 		4 / 6 THR D 167
ASP D 168
LEU D 172
ASP D 175
 None
 0.51A 5tdzA-2j7pD:
3.6		 5tdzA-2j7pD:
22.65