SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j7q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP
(Murid
betaherpesvirus
1) 		3 / 3 ASP A  59
LYS A  65
ARG A  68
 None
 1.14A 1ra8A-2j7qA:
undetectable		 1ra8A-2j7qA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP
(Murid
betaherpesvirus
1) 		5 / 9 ILE A 134
PHE A 121
VAL A 147
THR A 152
ALA A 177
 None
 1.12A 2m9qA-2j7qA:
undetectable		 2m9qA-2j7qA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP
(Murid
betaherpesvirus
1) 		3 / 3 ASP A  59
THR A  88
PRO A  89
 None
 0.72A 2pynB-2j7qA:
undetectable		 2pynB-2j7qA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP
(Murid
betaherpesvirus
1) 		3 / 3 ASP A  59
THR A  88
PRO A  89
 None
 0.71A 2qakB-2j7qA:
undetectable		 2qakB-2j7qA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP
(Murid
betaherpesvirus
1) 		5 / 12 LEU A  31
ILE A 134
LEU A 122
VAL A 168
PRO A 157
 None
 1.13A 2ygpA-2j7qA:
undetectable		 2ygpA-2j7qA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP
(Murid
betaherpesvirus
1) 		3 / 3 CYH A  34
HIS A  32
PHE A 200
 None
 1.14A 3cr4X-2j7qA:
0.0		 3cr4X-2j7qA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP
(Murid
betaherpesvirus
1) 		4 / 8 LEU A 116
TYR A 124
PHE A 121
TYR A 193
 None
 1.16A 3po7A-2j7qA:
undetectable		 3po7A-2j7qA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP
(Murid
betaherpesvirus
1) 		4 / 8 ALA A  90
GLY A  91
THR A  88
THR A  93
 None
 0.89A 3rglA-2j7qA:
undetectable		 3rglA-2j7qA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP
(Murid
betaherpesvirus
1) 		3 / 3 VAL A 132
LEU A 214
MET A 218
 None
 0.80A 5ikrA-2j7qA:
undetectable		 5ikrA-2j7qA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP
(Murid
betaherpesvirus
1) 		4 / 5 ILE A 146
LEU A  36
HIS A  95
VAL A 198
 None
 0.99A 5jmnB-2j7qA:
undetectable		 5jmnB-2j7qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP
(Murid
betaherpesvirus
1) 		5 / 12 TYR A 193
ILE A 135
PHE A 191
THR A 152
LEU A 122
 None
 1.34A 5v5zA-2j7qA:
undetectable		 5v5zA-2j7qA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP
(Murid
betaherpesvirus
1) 		5 / 12 ILE A  61
LEU A 213
LEU A  31
THR A  29
LEU A  58
 None
 1.18A 5xxiA-2j7qA:
undetectable		 5xxiA-2j7qA:
17.69