SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2j86'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE
(Synechococcus
elongatus) 		5 / 12 HIS A  52
GLU A  44
ILE A  83
ARG A  47
ALA A  19
 None
 1.48A 1ki7B-2j86A:
undetectable		 1ki7B-2j86A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE
(Synechococcus
elongatus) 		4 / 4 LEU A 208
SER A 209
TYR A 207
LEU A 220
 None
 1.12A 1xz1A-2j86A:
undetectable		 1xz1A-2j86A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE
(Synechococcus
elongatus) 		4 / 4 LEU A 208
SER A 209
TYR A 207
LEU A 220
 None
 1.13A 1xz3A-2j86A:
undetectable		 1xz3A-2j86A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE
(Synechococcus
elongatus) 		4 / 5 LEU A  48
ALA A  79
LEU A 167
MET A  36
 None
 1.06A 2oaxA-2j86A:
undetectable		 2oaxA-2j86A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE
(Synechococcus
elongatus) 		4 / 5 ILE A  83
LEU A 167
ASP A  34
ALA A  45
 None
None
MG  A1242 ( 2.1A)
None
 0.96A 2opxA-2j86A:
undetectable		 2opxA-2j86A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE
(Synechococcus
elongatus) 		5 / 12 LEU A 163
ASP A  18
ASN A 232
ASP A 231
ASP A 119
 None
None
None
MG  A1242 (-2.3A)
MG  A1241 (-2.9A)
 1.29A 2x2iA-2j86A:
undetectable		 2x2iA-2j86A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE
(Synechococcus
elongatus) 		5 / 12 ILE A  83
LEU A 163
GLU A  43
SER A 120
ASN A 232
 None
 1.26A 3eigA-2j86A:
undetectable		 3eigA-2j86A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE
(Synechococcus
elongatus) 		5 / 12 TYR A 123
GLY A 194
GLU A 197
LEU A 130
ARG A 187
 None
None
MG  A1241 ( 4.6A)
None
None
 1.00A 4wcxC-2j86A:
undetectable		 4wcxC-2j86A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE
(Synechococcus
elongatus) 		5 / 11 PHE A  20
LEU A  11
LEU A 195
GLY A 194
ALA A 223
 None
 1.25A 5fctA-2j86A:
undetectable		 5fctA-2j86A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE
(Synechococcus
elongatus) 		4 / 7 ILE A 175
VAL A 236
PHE A  30
ILE A 103
 None
 0.94A 5hieC-2j86A:
undetectable		 5hieC-2j86A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE
(Synechococcus
elongatus) 		5 / 12 GLY A 228
SER A 192
VAL A 235
VAL A 221
ASP A 222
 None
 1.36A 6bxlB-2j86A:
undetectable		 6bxlB-2j86A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE
(Synechococcus
elongatus) 		5 / 11 PHE A  20
LEU A  11
LEU A 195
GLY A 194
ALA A 223
 None
 1.28A 6r2eF-2j86A:
undetectable		 6r2eF-2j86A:
21.45